The Wnt antagonist secreted frizzled-related protein-1 controls osteoblast and osteocyte apoptosis

Mechanisms controlling human bone formation remain to be fully elucidated. We have used differential display‐polymerase chain reaction analysis to characterize osteogenic pathways in conditionally immortalized human osteoblasts (HOBs) representing distinct stages of differentiation. We identified 82...

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Veröffentlicht in:	Journal of cellular biochemistry 2005-12, Vol.96 (6), p.1212-1230
Hauptverfasser:	Bodine, Peter V.N., Billiard, Julia, Moran, Robert A., Ponce-de-Leon, Helga, McLarney, Sean, Mangine, Annamarie, Scrimo, Melissa J., Bhat, Ramesh A., Stauffer, Barbara, Green, Jack, Stein, Gary S., Lian, Jane B., Komm, Barry S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Annexin A5 - metabolism Annexin A5 - pharmacology apoptosis Apoptosis - drug effects Apoptosis - physiology bone Cell Differentiation - drug effects Cells, Cultured Dinoprostone - metabolism Dinoprostone - pharmacology Gene Expression Regulation - drug effects Humans In Situ Hybridization Mice osteoblast Osteoblasts - drug effects Osteoblasts - metabolism osteocyte Osteocytes - drug effects Osteocytes - metabolism programmed cell death Proteins - metabolism Proteins - pharmacology Rats Recombinant Fusion Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism sFRP-1 Signal Transduction - physiology Transforming Growth Factor beta - metabolism Transforming Growth Factor beta - pharmacology Transforming Growth Factor beta1 Wnt Wnt Proteins - antagonists & inhibitors Wnt Proteins - metabolism
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