Synthesis of Uniform Protein−Polymer Conjugates

We have developed a novel technique to synthesize near-uniform protein−polymer conjugates by initiating atom transfer radical polymerization of monomethoxy poly(ethylene glycol)−methacrylate from 2-bromoisobutyramide derivatives of chymotrypsin (a protein−initiator). Polymerization initiated from th...

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Veröffentlicht in:	Biomacromolecules 2005-11, Vol.6 (6), p.3380-3387
Hauptverfasser:	Lele, Bhalchandra S, Murata, Hironobu, Matyjaszewski, Krzysztof, Russell, Alan J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemistry Amino Acid Sequence Animals Anions Applied sciences Biocompatible Materials - chemistry Catalysis Cattle Chymotrypsin - chemistry Exact sciences and technology Macromolecular Substances - chemistry Methacrylates - chemistry Models, Chemical Molecular Sequence Data Molecular Weight Natural polymers Pancreas - metabolism Peptides - chemistry Physicochemistry of polymers Polyethylene Glycols - chemistry Polymers - chemical synthesis Polymers - chemistry Protein Binding Proteins Proteins - chemical synthesis Proteins - chemistry Reducing Agents - chemistry Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Time Factors Trypsin - chemistry Trypsin - pharmacology
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