Interleukin-6 polymorphism and Helicobacter pylori infection in Brazilian adult patients with chronic gastritis
Helicobacter pylori is recognised as the most common cause of chronic active gastritis and this bacterium is also an important pathogenic factor in peptic ulcer disease. The biological factors that influence clinical outcome in H. pylori infection have been extensively studied. In addition to immuno...
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| Veröffentlicht in: | Clinical and experimental medicine 2005-10, Vol.5 (3), p.112-116 |
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| creator | Lobo Gatti, L Zambaldi Tunes, M de Lábio, R W Silva, L C de Arruda Cardoso Smith, M Marques Payão, S L |
| description | Helicobacter pylori is recognised as the most common cause of chronic active gastritis and this bacterium is also an important pathogenic factor in peptic ulcer disease. The biological factors that influence clinical outcome in H. pylori infection have been extensively studied. In addition to immunological factors in the host, bacterial virulence determinants in H. pylori strains are likely to play a crucial role in gastric cancer development. Singlenucleotide polymorphisms at the 5' flanking region of the interleukin (IL)-6 gene promoter (G or C at -174 base) have been identified and individuals with the G allele at position -174 have been shown to produce higher levels of IL-6 than those with the C/C genotype. The mucosal levels of IL-6 were reported to be increased in H. pylori-associated gastritis. The present study was conducted to examine any relationship between inflammatory cytokine polymorphisms and the inflammatory process in mucosa infected by H. pylori. In our study we did not find any association between the C and G alleles in adult patients with chronic gastritis and inflammatory process in gastric mucosa. |
| doi_str_mv | 10.1007/s10238-005-0074-3 |
| format | Article |
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The biological factors that influence clinical outcome in H. pylori infection have been extensively studied. In addition to immunological factors in the host, bacterial virulence determinants in H. pylori strains are likely to play a crucial role in gastric cancer development. Singlenucleotide polymorphisms at the 5' flanking region of the interleukin (IL)-6 gene promoter (G or C at -174 base) have been identified and individuals with the G allele at position -174 have been shown to produce higher levels of IL-6 than those with the C/C genotype. The mucosal levels of IL-6 were reported to be increased in H. pylori-associated gastritis. The present study was conducted to examine any relationship between inflammatory cytokine polymorphisms and the inflammatory process in mucosa infected by H. pylori. In our study we did not find any association between the C and G alleles in adult patients with chronic gastritis and inflammatory process in gastric mucosa.</description><identifier>ISSN: 1591-8890</identifier><identifier>EISSN: 1591-9528</identifier><identifier>DOI: 10.1007/s10238-005-0074-3</identifier><identifier>PMID: 16284733</identifier><identifier>CODEN: CEMLBA</identifier><language>eng</language><publisher>Italy: Springer Nature B.V</publisher><subject>Adult ; Adults ; Bacteria ; Brazil ; Chronic Disease ; Cytokines ; Digestive system ; Female ; Gastritis - genetics ; Gastritis - microbiology ; Gene Frequency ; Helicobacter Infections - genetics ; Helicobacter pylori ; Humans ; Interleukin-6 - genetics ; Male ; Medical disorders ; Polymorphism ; Polymorphism, Genetic ; Polymorphism, Restriction Fragment Length</subject><ispartof>Clinical and experimental medicine, 2005-10, Vol.5 (3), p.112-116</ispartof><rights>Springer-Verlag Italia 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-670f14807c2461141e54150ec8f36b8cf42a63be2a31046bb89e5bcb502059423</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16284733$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lobo Gatti, L</creatorcontrib><creatorcontrib>Zambaldi Tunes, M</creatorcontrib><creatorcontrib>de Lábio, R W</creatorcontrib><creatorcontrib>Silva, L C</creatorcontrib><creatorcontrib>de Arruda Cardoso Smith, M</creatorcontrib><creatorcontrib>Marques Payão, S L</creatorcontrib><title>Interleukin-6 polymorphism and Helicobacter pylori infection in Brazilian adult patients with chronic gastritis</title><title>Clinical and experimental medicine</title><addtitle>Clin Exp Med</addtitle><description>Helicobacter pylori is recognised as the most common cause of chronic active gastritis and this bacterium is also an important pathogenic factor in peptic ulcer disease. The biological factors that influence clinical outcome in H. pylori infection have been extensively studied. In addition to immunological factors in the host, bacterial virulence determinants in H. pylori strains are likely to play a crucial role in gastric cancer development. Singlenucleotide polymorphisms at the 5' flanking region of the interleukin (IL)-6 gene promoter (G or C at -174 base) have been identified and individuals with the G allele at position -174 have been shown to produce higher levels of IL-6 than those with the C/C genotype. The mucosal levels of IL-6 were reported to be increased in H. pylori-associated gastritis. The present study was conducted to examine any relationship between inflammatory cytokine polymorphisms and the inflammatory process in mucosa infected by H. pylori. In our study we did not find any association between the C and G alleles in adult patients with chronic gastritis and inflammatory process in gastric mucosa.</description><subject>Adult</subject><subject>Adults</subject><subject>Bacteria</subject><subject>Brazil</subject><subject>Chronic Disease</subject><subject>Cytokines</subject><subject>Digestive system</subject><subject>Female</subject><subject>Gastritis - genetics</subject><subject>Gastritis - microbiology</subject><subject>Gene Frequency</subject><subject>Helicobacter Infections - genetics</subject><subject>Helicobacter pylori</subject><subject>Humans</subject><subject>Interleukin-6 - genetics</subject><subject>Male</subject><subject>Medical disorders</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Restriction Fragment Length</subject><issn>1591-8890</issn><issn>1591-9528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkc9rFTEQx4NYbK3-AV4keOht7eR39qjF2kLBi55DNi_rS80ma5JFnn-9Ke-B4MXDMHP4fAdmPgi9IfCeAKjrSoAyPQCIXooP7Bm6IGIkwyiofn6atR7hHL2s9RGACM3gBTonkmquGLtA-T41X6LffoQ0SLzmeFhyWfehLtimHb7zMbg8WdcpvB5iLgGHNHvXQk59wh-L_R1isAnb3RYbXm0LPrWKf4W2x25fcgoOf7e1ldBCfYXOZhurf33ql-jb7aevN3fDw5fP9zcfHgbHhGqDVDATrkE5yiUhnHjBiQDv9MzkpN3MqZVs8tQyAlxOkx69mNwkgIIYOWWX6Oq4dy355-ZrM0uozsdok89bNVKrUYIc_wtS6M8kQnXw3T_gY95K6kcYykCBpkJ0iBwhV3Ktxc9mLWGx5WAImCdn5ujMdGfmyZlhPfP2tHibFr_7mzhJYn8Ars2SHg</recordid><startdate>200510</startdate><enddate>200510</enddate><creator>Lobo Gatti, L</creator><creator>Zambaldi Tunes, M</creator><creator>de Lábio, R W</creator><creator>Silva, L C</creator><creator>de Arruda Cardoso Smith, M</creator><creator>Marques Payão, S L</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>200510</creationdate><title>Interleukin-6 polymorphism and Helicobacter pylori infection in Brazilian adult patients with chronic gastritis</title><author>Lobo Gatti, L ; 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The biological factors that influence clinical outcome in H. pylori infection have been extensively studied. In addition to immunological factors in the host, bacterial virulence determinants in H. pylori strains are likely to play a crucial role in gastric cancer development. Singlenucleotide polymorphisms at the 5' flanking region of the interleukin (IL)-6 gene promoter (G or C at -174 base) have been identified and individuals with the G allele at position -174 have been shown to produce higher levels of IL-6 than those with the C/C genotype. The mucosal levels of IL-6 were reported to be increased in H. pylori-associated gastritis. The present study was conducted to examine any relationship between inflammatory cytokine polymorphisms and the inflammatory process in mucosa infected by H. pylori. 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| ispartof | Clinical and experimental medicine, 2005-10, Vol.5 (3), p.112-116 |
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| subjects | Adult Adults Bacteria Brazil Chronic Disease Cytokines Digestive system Female Gastritis - genetics Gastritis - microbiology Gene Frequency Helicobacter Infections - genetics Helicobacter pylori Humans Interleukin-6 - genetics Male Medical disorders Polymorphism Polymorphism, Genetic Polymorphism, Restriction Fragment Length |
| title | Interleukin-6 polymorphism and Helicobacter pylori infection in Brazilian adult patients with chronic gastritis |
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