Fgf8 expression defines a morphogenetic center required for olfactory neurogenesis and nasal cavity development in the mouse

In vertebrate olfactory epithelium (OE), neurogenesis proceeds continuously, suggesting that endogenous signals support survival and proliferation of stem and progenitor cells. We used a genetic approach to test the hypothesis that Fgf8 plays such a role in developing OE. In young embryos, Fgf8 RNA...

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Veröffentlicht in:	Development (Cambridge) 2005-12, Vol.132 (23), p.5211-5223
Hauptverfasser:	Kawauchi, Shimako, Shou, Jianyong, Santos, Rosaysela, Hébert, Jean M, McConnell, Susan K, Mason, Ivor, Calof, Anne L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Embryonic Development Fibroblast Growth Factor 8 - genetics Fibroblast Growth Factor 8 - physiology Gene Expression Regulation, Developmental Mice Mice, Mutant Strains Morphogenesis Mutation Nasal Cavity - embryology Nasal Cavity - growth & development Nasal Cavity - innervation Neurons - cytology Olfactory Nerve - embryology Olfactory Nerve - growth & development RNA, Messenger - analysis Signal Transduction Stem Cells
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