Enhanced behavioral response to repeated-dose cocaine in adolescent rats
Most lifelong drug addiction in humans originates during adolescence. Important structural and functional changes in the brain occur during adolescence, but there has been little direct study of how this impacts on drug abuse vulnerability. An emerging literature suggests that adolescents exhibit di...
Gespeichert in:
| Veröffentlicht in: | Psychopharmacologia 2005-12, Vol.183 (2), p.218-225 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 225 |
|---|---|
| container_issue | 2 |
| container_start_page | 218 |
| container_title | Psychopharmacologia |
| container_volume | 183 |
| creator | CASTER, Joseph M WALKER, Q. David KUHN, Cynthia M |
| description | Most lifelong drug addiction in humans originates during adolescence. Important structural and functional changes in the brain occur during adolescence, but there has been little direct study of how this impacts on drug abuse vulnerability. An emerging literature suggests that adolescents exhibit different behavioral responses to single doses of several addictive drugs, including ethanol, amphetamine, and cocaine. However, few studies have explored behavioral responses to the repeated dosing that is characteristic of human abuse of these substances.
We have investigated age-related behavioral responses to acute "binge" cocaine treatment between adults and adolescents.
Adolescent rats displayed an exaggerated behavioral response to cocaine administered in two different binge patterns. Total locomotion after cocaine administration was the same in adolescents and adults. However, adolescent rats engaged in more intense stereotypic behaviors, including paw treading, head weaving, and focused sniffing than adult rats. These differences were observable following a modest dose of cocaine and became more robust following subsequent doses within a binge. Cocaine [corrected] brain levels were not significantly different between age groups during any of the exposure sessions.
These findings suggest that equivalent tissue concentrations of cocaine produce a greater behavioral response in young rats, and that adolescent animals display an apparent form of intrabinge sensitization. |
| doi_str_mv | 10.1007/s00213-005-0159-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68795502</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68795502</sourcerecordid><originalsourceid>FETCH-LOGICAL-c387t-8a55db30a13065db9a94f24ae27126eaf68d3e83d9b2687a396f4b05f860b4873</originalsourceid><addsrcrecordid>eNqFkU2LFDEQhoMo7rj6A7xII-gtWpXvHGVZXWHBi55DdXc120tPZ0x6BP_9ZpmBBS_mkqJ43iKpR4i3CJ8QwH-uAAq1BLAS0EZpnokdGq2kAq-eix2A1lKjDRfiVa330I4J5qW4QIfeGjA7cXO93tE68Nj1fEd_5lxo6QrXQ14rd1tu9YFp41GOuTWGPNC8cjevHY154TrwunWFtvpavJhoqfzmfF-KX1-vf17dyNsf375ffbmVgw5-k4GsHXsNhBpcqyJFMylDrDwqxzS5MGoOeoy9csGTjm4yPdgpOOhN8PpSfDzNPZT8-8h1S_u5vWJZaOV8rKmForWg_guiVxACYgPf_wPe52NZ2yeSwhCdCto2CE_QUHKthad0KPOeyt-EkB5lpJOM1GSkRxnJtMy78-Bjv-fxKXHefgM-nAGqAy1TaSbm-sR5EzEqpx8AmHGP-Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>218962835</pqid></control><display><type>article</type><title>Enhanced behavioral response to repeated-dose cocaine in adolescent rats</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>CASTER, Joseph M ; WALKER, Q. David ; KUHN, Cynthia M</creator><creatorcontrib>CASTER, Joseph M ; WALKER, Q. David ; KUHN, Cynthia M</creatorcontrib><description>Most lifelong drug addiction in humans originates during adolescence. Important structural and functional changes in the brain occur during adolescence, but there has been little direct study of how this impacts on drug abuse vulnerability. An emerging literature suggests that adolescents exhibit different behavioral responses to single doses of several addictive drugs, including ethanol, amphetamine, and cocaine. However, few studies have explored behavioral responses to the repeated dosing that is characteristic of human abuse of these substances.
We have investigated age-related behavioral responses to acute "binge" cocaine treatment between adults and adolescents.
Adolescent rats displayed an exaggerated behavioral response to cocaine administered in two different binge patterns. Total locomotion after cocaine administration was the same in adolescents and adults. However, adolescent rats engaged in more intense stereotypic behaviors, including paw treading, head weaving, and focused sniffing than adult rats. These differences were observable following a modest dose of cocaine and became more robust following subsequent doses within a binge. Cocaine [corrected] brain levels were not significantly different between age groups during any of the exposure sessions.
These findings suggest that equivalent tissue concentrations of cocaine produce a greater behavioral response in young rats, and that adolescent animals display an apparent form of intrabinge sensitization.</description><identifier>ISSN: 0033-3158</identifier><identifier>EISSN: 1432-2072</identifier><identifier>DOI: 10.1007/s00213-005-0159-4</identifier><identifier>PMID: 16175404</identifier><identifier>CODEN: PSYPAG</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Age Factors ; Analysis of Variance ; Animals ; Animals, Newborn ; Behavior, Addictive - psychology ; Behavior, Animal - drug effects ; Biological and medical sciences ; Brain - drug effects ; Brain - metabolism ; Cocaine - administration & dosage ; Cocaine - blood ; Dopamine Uptake Inhibitors - administration & dosage ; Dose-Response Relationship, Drug ; Drug addictions ; Drug Administration Schedule ; Locomotion - drug effects ; Male ; Medical sciences ; Neuropharmacology ; Pharmacology. Drug treatments ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Rats ; Rats, Sprague-Dawley ; Stereotyped Behavior - drug effects ; Time Factors ; Toxicology</subject><ispartof>Psychopharmacologia, 2005-12, Vol.183 (2), p.218-225</ispartof><rights>2006 INIST-CNRS</rights><rights>Springer-Verlag 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-8a55db30a13065db9a94f24ae27126eaf68d3e83d9b2687a396f4b05f860b4873</citedby><cites>FETCH-LOGICAL-c387t-8a55db30a13065db9a94f24ae27126eaf68d3e83d9b2687a396f4b05f860b4873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17491926$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16175404$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CASTER, Joseph M</creatorcontrib><creatorcontrib>WALKER, Q. David</creatorcontrib><creatorcontrib>KUHN, Cynthia M</creatorcontrib><title>Enhanced behavioral response to repeated-dose cocaine in adolescent rats</title><title>Psychopharmacologia</title><addtitle>Psychopharmacology (Berl)</addtitle><description>Most lifelong drug addiction in humans originates during adolescence. Important structural and functional changes in the brain occur during adolescence, but there has been little direct study of how this impacts on drug abuse vulnerability. An emerging literature suggests that adolescents exhibit different behavioral responses to single doses of several addictive drugs, including ethanol, amphetamine, and cocaine. However, few studies have explored behavioral responses to the repeated dosing that is characteristic of human abuse of these substances.
We have investigated age-related behavioral responses to acute "binge" cocaine treatment between adults and adolescents.
Adolescent rats displayed an exaggerated behavioral response to cocaine administered in two different binge patterns. Total locomotion after cocaine administration was the same in adolescents and adults. However, adolescent rats engaged in more intense stereotypic behaviors, including paw treading, head weaving, and focused sniffing than adult rats. These differences were observable following a modest dose of cocaine and became more robust following subsequent doses within a binge. Cocaine [corrected] brain levels were not significantly different between age groups during any of the exposure sessions.
These findings suggest that equivalent tissue concentrations of cocaine produce a greater behavioral response in young rats, and that adolescent animals display an apparent form of intrabinge sensitization.</description><subject>Age Factors</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Behavior, Addictive - psychology</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Cocaine - administration & dosage</subject><subject>Cocaine - blood</subject><subject>Dopamine Uptake Inhibitors - administration & dosage</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug addictions</subject><subject>Drug Administration Schedule</subject><subject>Locomotion - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Stereotyped Behavior - drug effects</subject><subject>Time Factors</subject><subject>Toxicology</subject><issn>0033-3158</issn><issn>1432-2072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkU2LFDEQhoMo7rj6A7xII-gtWpXvHGVZXWHBi55DdXc120tPZ0x6BP_9ZpmBBS_mkqJ43iKpR4i3CJ8QwH-uAAq1BLAS0EZpnokdGq2kAq-eix2A1lKjDRfiVa330I4J5qW4QIfeGjA7cXO93tE68Nj1fEd_5lxo6QrXQ14rd1tu9YFp41GOuTWGPNC8cjevHY154TrwunWFtvpavJhoqfzmfF-KX1-vf17dyNsf375ffbmVgw5-k4GsHXsNhBpcqyJFMylDrDwqxzS5MGoOeoy9csGTjm4yPdgpOOhN8PpSfDzNPZT8-8h1S_u5vWJZaOV8rKmForWg_guiVxACYgPf_wPe52NZ2yeSwhCdCto2CE_QUHKthad0KPOeyt-EkB5lpJOM1GSkRxnJtMy78-Bjv-fxKXHefgM-nAGqAy1TaSbm-sR5EzEqpx8AmHGP-Q</recordid><startdate>20051201</startdate><enddate>20051201</enddate><creator>CASTER, Joseph M</creator><creator>WALKER, Q. David</creator><creator>KUHN, Cynthia M</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QR</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20051201</creationdate><title>Enhanced behavioral response to repeated-dose cocaine in adolescent rats</title><author>CASTER, Joseph M ; WALKER, Q. David ; KUHN, Cynthia M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-8a55db30a13065db9a94f24ae27126eaf68d3e83d9b2687a396f4b05f860b4873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Age Factors</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Behavior, Addictive - psychology</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Cocaine - administration & dosage</topic><topic>Cocaine - blood</topic><topic>Dopamine Uptake Inhibitors - administration & dosage</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug addictions</topic><topic>Drug Administration Schedule</topic><topic>Locomotion - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Stereotyped Behavior - drug effects</topic><topic>Time Factors</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CASTER, Joseph M</creatorcontrib><creatorcontrib>WALKER, Q. David</creatorcontrib><creatorcontrib>KUHN, Cynthia M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Psychopharmacologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CASTER, Joseph M</au><au>WALKER, Q. David</au><au>KUHN, Cynthia M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhanced behavioral response to repeated-dose cocaine in adolescent rats</atitle><jtitle>Psychopharmacologia</jtitle><addtitle>Psychopharmacology (Berl)</addtitle><date>2005-12-01</date><risdate>2005</risdate><volume>183</volume><issue>2</issue><spage>218</spage><epage>225</epage><pages>218-225</pages><issn>0033-3158</issn><eissn>1432-2072</eissn><coden>PSYPAG</coden><abstract>Most lifelong drug addiction in humans originates during adolescence. Important structural and functional changes in the brain occur during adolescence, but there has been little direct study of how this impacts on drug abuse vulnerability. An emerging literature suggests that adolescents exhibit different behavioral responses to single doses of several addictive drugs, including ethanol, amphetamine, and cocaine. However, few studies have explored behavioral responses to the repeated dosing that is characteristic of human abuse of these substances.
We have investigated age-related behavioral responses to acute "binge" cocaine treatment between adults and adolescents.
Adolescent rats displayed an exaggerated behavioral response to cocaine administered in two different binge patterns. Total locomotion after cocaine administration was the same in adolescents and adults. However, adolescent rats engaged in more intense stereotypic behaviors, including paw treading, head weaving, and focused sniffing than adult rats. These differences were observable following a modest dose of cocaine and became more robust following subsequent doses within a binge. Cocaine [corrected] brain levels were not significantly different between age groups during any of the exposure sessions.
These findings suggest that equivalent tissue concentrations of cocaine produce a greater behavioral response in young rats, and that adolescent animals display an apparent form of intrabinge sensitization.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>16175404</pmid><doi>10.1007/s00213-005-0159-4</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0033-3158 |
| ispartof | Psychopharmacologia, 2005-12, Vol.183 (2), p.218-225 |
| issn | 0033-3158 1432-2072 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68795502 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Age Factors Analysis of Variance Animals Animals, Newborn Behavior, Addictive - psychology Behavior, Animal - drug effects Biological and medical sciences Brain - drug effects Brain - metabolism Cocaine - administration & dosage Cocaine - blood Dopamine Uptake Inhibitors - administration & dosage Dose-Response Relationship, Drug Drug addictions Drug Administration Schedule Locomotion - drug effects Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Sprague-Dawley Stereotyped Behavior - drug effects Time Factors Toxicology |
| title | Enhanced behavioral response to repeated-dose cocaine in adolescent rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-14T06%3A38%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Enhanced%20behavioral%20response%20to%20repeated-dose%20cocaine%20in%20adolescent%20rats&rft.jtitle=Psychopharmacologia&rft.au=CASTER,%20Joseph%20M&rft.date=2005-12-01&rft.volume=183&rft.issue=2&rft.spage=218&rft.epage=225&rft.pages=218-225&rft.issn=0033-3158&rft.eissn=1432-2072&rft.coden=PSYPAG&rft_id=info:doi/10.1007/s00213-005-0159-4&rft_dat=%3Cproquest_cross%3E68795502%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=218962835&rft_id=info:pmid/16175404&rfr_iscdi=true |