Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the amish : Replication and evidence for a role in both insulin secretion and insulin resistance

Transcription factor 7-like 2 (TCF7L2) regulates genes involved in cell proliferation and differentiation. The TCF7L2 gene is located on chromosome 10q25 in a region of replicated linkage to type 2 diabetes. Recently, a microsatellite marker in intron 3 (DG10S478) and five correlated single nucleoti...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2006-09, Vol.55 (9), p.2654-2659
Hauptverfasser:	DAMCOTT, Coleen M, POLLIN, Toni I, REINHART, Laurie J, OTT, Sandra H, HAIQING SHEN, SILVER, Kristi D, MITCHELL, Braxton D, SHULDINER, Alan R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Analysis Biological and medical sciences Blood Glucose - metabolism Cell growth Cell proliferation Chromosomes Diabetes Diabetes Mellitus, Type 2 - genetics Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Ethnic Groups - genetics Etiopathogenesis. Screening. Investigations. Target tissue resistance European Continental Ancestry Group - genetics Female Gene Frequency Genes Genetic aspects Genetic polymorphisms Genetic transcription Genomes Genotype & phenotype Glucose Humans Insulin - metabolism Insulin resistance Insulin Resistance - genetics Insulin Secretion Linkage Disequilibrium Male Medical sciences Middle Aged Pennsylvania Polymorphism, Single Nucleotide Risk factors TCF Transcription Factors - genetics TCF Transcription Factors - physiology Transcription (Genetics) Transcription Factor 7-Like 2 Protein Transcription factors Type 2 diabetes White people
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