Synthesis of Two 3,5-Disubstituted Sulfonamide Catechol Ligands and Evaluation of Their Iron(III) Complexes for Use as MRI Contrast Agents

Two 3,5-disubstituted sulfonamide catechol ligands were synthesized. Tris(ligand) iron(III) complexes were prepared and investigated as MRI contrast agents. Longitudinal relaxivity (r1) values were determined for the complexes. The r1 values in water were substantially higher than those of typical s...

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Veröffentlicht in:	Journal of medicinal chemistry 2005-11, Vol.48 (23), p.7482-7485
Hauptverfasser:	Schwert, Daniel D, Richardson, Nicholas, Ji, Gongjun, Radüchel, Bernd, Ebert, Wolfgang, Heffner, Peter E, Keck, Rick, Davies, Julian A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Catechols - chemical synthesis Catechols - chemistry Catechols - pharmacology Contrast Media - chemical synthesis Contrast Media - chemistry Contrast Media - pharmacology Contrast media. Radiopharmaceuticals Female Ferric Compounds - chemical synthesis Ferric Compounds - chemistry Ferric Compounds - pharmacology Gadolinium DTPA - pharmacology Investigative techniques, diagnostic techniques (general aspects) Iron Chelating Agents - chemical synthesis Iron Chelating Agents - chemistry Iron Chelating Agents - pharmacology Kidney - anatomy & histology Ligands Liver - anatomy & histology Magnetic Resonance Imaging Medical sciences Miscellaneous. Technology Pharmacology. Drug treatments Radiodiagnosis. Nmr imagery. Nmr spectrometry Rats Rats, Inbred F344 Structure-Activity Relationship Sulfonamides - chemical synthesis Sulfonamides - chemistry Sulfonamides - pharmacology
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