Vitamin D Receptor Polymorphisms are Associated with Graves' Disease in German and Polish But not in Serbian Patients
Diverse genes are candidates for susceptibility to Graves' disease, including the vitamin D receptor (VDR), which regulates the transcription of target genes in response to the active metabolite 1,25(OH) 2 D 3 . We analyzed four polymorphisms of the VDR gene ( ApaI, TaqI, BsmI , and FokI ) in p...
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| Veröffentlicht in: | Thyroid (New York, N.Y.) N.Y.), 2005-10, Vol.15 (10), p.1125-1130 |
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| creator | Ramos-Lopez, Elizabeth Kurylowicz, Alina Bednarczuk, Tomasz Paunkovic, Jane Seidl, Christian Badenhoop, Klaus |
| description | Diverse genes are candidates for susceptibility to Graves' disease, including the vitamin D receptor (VDR),
which regulates the transcription of target genes in response to the active metabolite 1,25(OH)
2
D
3
. We analyzed
four polymorphisms of the VDR gene (
ApaI, TaqI, BsmI
, and
FokI
) in patients with Graves' disease (
n
= 789)
and healthy controls (
n
= 823) from three European populations (German, Polish, and Serbian). The VDR
Apa
I
(rs7975232) and
Taq
I (rs731236) polymorphisms showed no significant difference in any population. The
Bsm
I
(rs1544410) variant "
b
" was associated with Graves' disease in the Polish population (
p
= 0.0070). The
Fok
I
(rs10735810) variant "
f
" was found to be associated with Graves' disease in Germans and "
F
" in Polish patients
(
p
= 0.0024 and 0.0049, respectively). Construction of haplotypes for
Taq
I,
Apa
I, and
Bsm
I showed the haplotype
"
Tab
" to be the most frequent in the German and Polish population as well as in the Serbian patients,
while "
tAB
" in Serbian controls. Our results show an association of VDR gene polymorphisms in the German
and Polish population but not in the Serbian. Furthermore, the VDR polymorphisms are differentially distributed
in the three populations. Therefore, VDR polymorphisms analysis needs to be stratified according to the
population background. |
| doi_str_mv | 10.1089/thy.2005.15.1125 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68793501</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68793501</sourcerecordid><originalsourceid>FETCH-LOGICAL-c336t-a49b062c1018306ac44eb1902e2e19163527de623e2b862b7cdf6765d3c809163</originalsourceid><addsrcrecordid>eNplkE1PGzEQhq2qqKGUe0-VT-1pw9gb27tHCG1AQiKiwHXl9U4UV_uReryg_Pt6lagckEaa0bwfh4exrwLmAoryIm73cwmg5iKNkOoDOxVKmawEYz6mGxRkRio9Y5-J_gAIXZj8E5sJLU1ZLNQpG599tJ3v-TV_QIe7OAS-Htp9N4Td1lNH3Abkl0SD8zZiw1993PJVsC9IP_i1J7SEPOVXGDrbc9s3U97Tll-NkfdDnMTfGGqf1LWNHvtIX9jJxraE58d9xp5-_Xxc3mR396vb5eVd5vJcx8wuyhq0dAJEkYO2brHAWpQgUaIohc6VNA1qmaOsCy1r45qNNlo1uStg0s_Y90PvLgx_R6RYdZ4ctq3tcRipSjjKXIFIRjgYXRiIAm6qXfCdDftKQDWhrhLqakJdiTQJdYp8O3aPdYfNW-DINhnmB8P0tn3feqwxxP_Gd43_AHAriiU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68793501</pqid></control><display><type>article</type><title>Vitamin D Receptor Polymorphisms are Associated with Graves' Disease in German and Polish But not in Serbian Patients</title><source>Mary Ann Liebert Online Subscription</source><source>MEDLINE</source><creator>Ramos-Lopez, Elizabeth ; Kurylowicz, Alina ; Bednarczuk, Tomasz ; Paunkovic, Jane ; Seidl, Christian ; Badenhoop, Klaus</creator><creatorcontrib>Ramos-Lopez, Elizabeth ; Kurylowicz, Alina ; Bednarczuk, Tomasz ; Paunkovic, Jane ; Seidl, Christian ; Badenhoop, Klaus</creatorcontrib><description>Diverse genes are candidates for susceptibility to Graves' disease, including the vitamin D receptor (VDR),
which regulates the transcription of target genes in response to the active metabolite 1,25(OH)
2
D
3
. We analyzed
four polymorphisms of the VDR gene (
ApaI, TaqI, BsmI
, and
FokI
) in patients with Graves' disease (
n
= 789)
and healthy controls (
n
= 823) from three European populations (German, Polish, and Serbian). The VDR
Apa
I
(rs7975232) and
Taq
I (rs731236) polymorphisms showed no significant difference in any population. The
Bsm
I
(rs1544410) variant "
b
" was associated with Graves' disease in the Polish population (
p
= 0.0070). The
Fok
I
(rs10735810) variant "
f
" was found to be associated with Graves' disease in Germans and "
F
" in Polish patients
(
p
= 0.0024 and 0.0049, respectively). Construction of haplotypes for
Taq
I,
Apa
I, and
Bsm
I showed the haplotype
"
Tab
" to be the most frequent in the German and Polish population as well as in the Serbian patients,
while "
tAB
" in Serbian controls. Our results show an association of VDR gene polymorphisms in the German
and Polish population but not in the Serbian. Furthermore, the VDR polymorphisms are differentially distributed
in the three populations. Therefore, VDR polymorphisms analysis needs to be stratified according to the
population background.</description><identifier>ISSN: 1050-7256</identifier><identifier>EISSN: 1557-9077</identifier><identifier>DOI: 10.1089/thy.2005.15.1125</identifier><identifier>PMID: 16279845</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; European Continental Ancestry Group - genetics ; Female ; Germany ; Graves Disease - genetics ; Haplotypes ; Humans ; Laboratory Research Reports ; Male ; Middle Aged ; Poland ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide ; Receptors, Calcitriol - genetics ; Yugoslavia</subject><ispartof>Thyroid (New York, N.Y.), 2005-10, Vol.15 (10), p.1125-1130</ispartof><rights>2005, Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c336t-a49b062c1018306ac44eb1902e2e19163527de623e2b862b7cdf6765d3c809163</citedby><cites>FETCH-LOGICAL-c336t-a49b062c1018306ac44eb1902e2e19163527de623e2b862b7cdf6765d3c809163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.liebertpub.com/doi/epdf/10.1089/thy.2005.15.1125$$EPDF$$P50$$Gmaryannliebert$$H</linktopdf><linktohtml>$$Uhttps://www.liebertpub.com/doi/full/10.1089/thy.2005.15.1125$$EHTML$$P50$$Gmaryannliebert$$H</linktohtml><link.rule.ids>314,780,784,3042,21723,27924,27925,55291,55303</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16279845$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ramos-Lopez, Elizabeth</creatorcontrib><creatorcontrib>Kurylowicz, Alina</creatorcontrib><creatorcontrib>Bednarczuk, Tomasz</creatorcontrib><creatorcontrib>Paunkovic, Jane</creatorcontrib><creatorcontrib>Seidl, Christian</creatorcontrib><creatorcontrib>Badenhoop, Klaus</creatorcontrib><title>Vitamin D Receptor Polymorphisms are Associated with Graves' Disease in German and Polish But not in Serbian Patients</title><title>Thyroid (New York, N.Y.)</title><addtitle>Thyroid</addtitle><description>Diverse genes are candidates for susceptibility to Graves' disease, including the vitamin D receptor (VDR),
which regulates the transcription of target genes in response to the active metabolite 1,25(OH)
2
D
3
. We analyzed
four polymorphisms of the VDR gene (
ApaI, TaqI, BsmI
, and
FokI
) in patients with Graves' disease (
n
= 789)
and healthy controls (
n
= 823) from three European populations (German, Polish, and Serbian). The VDR
Apa
I
(rs7975232) and
Taq
I (rs731236) polymorphisms showed no significant difference in any population. The
Bsm
I
(rs1544410) variant "
b
" was associated with Graves' disease in the Polish population (
p
= 0.0070). The
Fok
I
(rs10735810) variant "
f
" was found to be associated with Graves' disease in Germans and "
F
" in Polish patients
(
p
= 0.0024 and 0.0049, respectively). Construction of haplotypes for
Taq
I,
Apa
I, and
Bsm
I showed the haplotype
"
Tab
" to be the most frequent in the German and Polish population as well as in the Serbian patients,
while "
tAB
" in Serbian controls. Our results show an association of VDR gene polymorphisms in the German
and Polish population but not in the Serbian. Furthermore, the VDR polymorphisms are differentially distributed
in the three populations. Therefore, VDR polymorphisms analysis needs to be stratified according to the
population background.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Female</subject><subject>Germany</subject><subject>Graves Disease - genetics</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Laboratory Research Reports</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Poland</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Receptors, Calcitriol - genetics</subject><subject>Yugoslavia</subject><issn>1050-7256</issn><issn>1557-9077</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkE1PGzEQhq2qqKGUe0-VT-1pw9gb27tHCG1AQiKiwHXl9U4UV_uReryg_Pt6lagckEaa0bwfh4exrwLmAoryIm73cwmg5iKNkOoDOxVKmawEYz6mGxRkRio9Y5-J_gAIXZj8E5sJLU1ZLNQpG599tJ3v-TV_QIe7OAS-Htp9N4Td1lNH3Abkl0SD8zZiw1993PJVsC9IP_i1J7SEPOVXGDrbc9s3U97Tll-NkfdDnMTfGGqf1LWNHvtIX9jJxraE58d9xp5-_Xxc3mR396vb5eVd5vJcx8wuyhq0dAJEkYO2brHAWpQgUaIohc6VNA1qmaOsCy1r45qNNlo1uStg0s_Y90PvLgx_R6RYdZ4ctq3tcRipSjjKXIFIRjgYXRiIAm6qXfCdDftKQDWhrhLqakJdiTQJdYp8O3aPdYfNW-DINhnmB8P0tn3feqwxxP_Gd43_AHAriiU</recordid><startdate>20051001</startdate><enddate>20051001</enddate><creator>Ramos-Lopez, Elizabeth</creator><creator>Kurylowicz, Alina</creator><creator>Bednarczuk, Tomasz</creator><creator>Paunkovic, Jane</creator><creator>Seidl, Christian</creator><creator>Badenhoop, Klaus</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20051001</creationdate><title>Vitamin D Receptor Polymorphisms are Associated with Graves' Disease in German and Polish But not in Serbian Patients</title><author>Ramos-Lopez, Elizabeth ; Kurylowicz, Alina ; Bednarczuk, Tomasz ; Paunkovic, Jane ; Seidl, Christian ; Badenhoop, Klaus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c336t-a49b062c1018306ac44eb1902e2e19163527de623e2b862b7cdf6765d3c809163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Female</topic><topic>Germany</topic><topic>Graves Disease - genetics</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>Laboratory Research Reports</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Poland</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Receptors, Calcitriol - genetics</topic><topic>Yugoslavia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramos-Lopez, Elizabeth</creatorcontrib><creatorcontrib>Kurylowicz, Alina</creatorcontrib><creatorcontrib>Bednarczuk, Tomasz</creatorcontrib><creatorcontrib>Paunkovic, Jane</creatorcontrib><creatorcontrib>Seidl, Christian</creatorcontrib><creatorcontrib>Badenhoop, Klaus</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thyroid (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramos-Lopez, Elizabeth</au><au>Kurylowicz, Alina</au><au>Bednarczuk, Tomasz</au><au>Paunkovic, Jane</au><au>Seidl, Christian</au><au>Badenhoop, Klaus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D Receptor Polymorphisms are Associated with Graves' Disease in German and Polish But not in Serbian Patients</atitle><jtitle>Thyroid (New York, N.Y.)</jtitle><addtitle>Thyroid</addtitle><date>2005-10-01</date><risdate>2005</risdate><volume>15</volume><issue>10</issue><spage>1125</spage><epage>1130</epage><pages>1125-1130</pages><issn>1050-7256</issn><eissn>1557-9077</eissn><abstract>Diverse genes are candidates for susceptibility to Graves' disease, including the vitamin D receptor (VDR),
which regulates the transcription of target genes in response to the active metabolite 1,25(OH)
2
D
3
. We analyzed
four polymorphisms of the VDR gene (
ApaI, TaqI, BsmI
, and
FokI
) in patients with Graves' disease (
n
= 789)
and healthy controls (
n
= 823) from three European populations (German, Polish, and Serbian). The VDR
Apa
I
(rs7975232) and
Taq
I (rs731236) polymorphisms showed no significant difference in any population. The
Bsm
I
(rs1544410) variant "
b
" was associated with Graves' disease in the Polish population (
p
= 0.0070). The
Fok
I
(rs10735810) variant "
f
" was found to be associated with Graves' disease in Germans and "
F
" in Polish patients
(
p
= 0.0024 and 0.0049, respectively). Construction of haplotypes for
Taq
I,
Apa
I, and
Bsm
I showed the haplotype
"
Tab
" to be the most frequent in the German and Polish population as well as in the Serbian patients,
while "
tAB
" in Serbian controls. Our results show an association of VDR gene polymorphisms in the German
and Polish population but not in the Serbian. Furthermore, the VDR polymorphisms are differentially distributed
in the three populations. Therefore, VDR polymorphisms analysis needs to be stratified according to the
population background.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>16279845</pmid><doi>10.1089/thy.2005.15.1125</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1050-7256 |
| ispartof | Thyroid (New York, N.Y.), 2005-10, Vol.15 (10), p.1125-1130 |
| issn | 1050-7256 1557-9077 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68793501 |
| source | Mary Ann Liebert Online Subscription; MEDLINE |
| subjects | Adult Aged Aged, 80 and over European Continental Ancestry Group - genetics Female Germany Graves Disease - genetics Haplotypes Humans Laboratory Research Reports Male Middle Aged Poland Polymorphism, Genetic Polymorphism, Single Nucleotide Receptors, Calcitriol - genetics Yugoslavia |
| title | Vitamin D Receptor Polymorphisms are Associated with Graves' Disease in German and Polish But not in Serbian Patients |
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