NRG1 gene rearrangements in clinical breast cancer: identification of an adjacent novel amplicon associated with poor prognosis

Rearrangements of the neuregulin ( NRG1 ) gene have been implicated in breast carcinoma oncogenesis. To determine the frequency and clinical significance of NRG1 aberrations in clinical breast tumors, a breast cancer tissue microarray was screened for NRG1 aberrations by fluorescent in situ hybridiz...

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Veröffentlicht in:	Oncogene 2005-11, Vol.24 (49), p.7281-7289
Hauptverfasser:	Prentice, Leah M, Shadeo, Ashleen, Lestou, Valia S, Miller, Melinda A, deLeeuw, Ronald J, Makretsov, Nikita, Turbin, Dmitry, Brown, Lindsay A, Macpherson, Nicol, Yorida, Erika, Cheang, Maggie C U, Bentley, John, Chia, Stephen, Nielsen, Torsten O, Gilks, C Blake, Lam, Wan, Huntsman, David G
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Artificial chromosomes Bacterial artificial chromosomes Biological and medical sciences Breakpoints Breast cancer Breast carcinoma Breast Neoplasms - genetics Breast Neoplasms - metabolism Cell Biology Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chromosome 8 Chromosome rearrangements Chromosomes, Artificial, Bacterial Chromosomes, Human, Pair 8 - genetics DNA microarrays DNA, Neoplasm - genetics DNA, Neoplasm - metabolism Epidermal growth factor Estrogen receptors Female Fluorescence in situ hybridization Fundamental and applied biological sciences. Psychology Gene Amplification Gene Expression Regulation, Neoplastic Gene Rearrangement Genes Gynecology. Andrology. Obstetrics Human Genetics Humans In Situ Hybridization, Fluorescence Internal Medicine Mammary gland diseases Medical sciences Medicine Medicine & Public Health Microarray Analysis Molecular and cellular biology Multivariate analysis Neuregulin Neuregulin 1 Neuregulin-1 - genetics Neuregulin-1 - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Nucleic Acid Hybridization Oncology original-paper Prognosis Receptor, Epidermal Growth Factor - metabolism Receptor, ErbB-2 - metabolism Receptor, ErbB-3 - metabolism Receptor, ErbB-4 Survival Rate Tumorigenesis Tumors Zinc Fingers
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