Variation Within the Gene Encoding the Upstream Stimulatory Factor 1 Does Not Influence Susceptibility to Type 2 Diabetes in Samples From Populations With Replicated Evidence of Linkage to Chromosome 1q

Variation Within the Gene Encoding the Upstream Stimulatory Factor 1 Does Not Influence Susceptibility to Type 2 Diabetes in Samples From Populations With Replicated Evidence of Linkage to Chromosome 1q Eleftheria Zeggini 1 2 , Coleen M. Damcott 3 , Robert L. Hanson 4 , Mohammad A. Karim 5 6 , N. William Rayner 1 2 , Christopher J. Groves 1 , Leslie J. Baier 4 , Terri C. Hale 5 6 , Andrew T. Hattersley 7 , Graham A. Hitman 8 , Sarah E. Hunt 9 , William C. Knowler 4 , Braxton D. Mitchell 3 , Maggie C.Y. Ng 10 11 , Jeffrey R. O’Connell 3 , Toni I. Pollin 3 , Martine Vaxillaire 12 , Mark Walker 13 , Xiaoqin Wang 5 6 , Pamela Whittaker 9 , Kunsan Xiang 14 , Weiping Jia 14 , Juliana C. N. Chan 11 , Philippe Froguel 12 15 , Panos Deloukas 9 , Alan R. Shuldiner 3 , Steven C. Elbein 5 6 , Mark I. McCarthy 1 2 and for the International Type 2 Diabetes 1q Consortium * 1 Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, U.K 2 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K 3 Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 4 Phoenix Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona 5 Endocrinology Section, Medical Service, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 6 Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas 7 Institute of Clinical and Biomedical Science, Peninsula Medical School, Exeter, U.K 8 Centre for Diabetes and Metabolic Medicine, Bart’s and the London Queen Mary’s School of Medicine and Dentistry, London, U.K 9 Wellcome Trust Sanger Institute, Hinxton, U.K 10 Department of Medicine, University of Chicago, Chicago, Illinois 11 Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong 12 Institut de Biologie de Lille, Lille, France 13 Department of Medicine, University of Newcastle, Newcastle, U.K 14 Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Jiaotong University No.6 People’s Hospital, Shanghai, China 15 Faculty of Life Sciences, Imperial College, London, U.K Address correspondence and reprint requests to Mark McCarthy, Robert Turner Professor of Diabetes, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchil