Synthesis of unique 17beta-estradiol homo-dimers, estrogen receptors binding affinity evaluation and cytocidal activity on breast, intestinal and skin cancer cell lines

A rapid and efficient synthesis of a series of C2-symmetric 17beta-estradiol homo-dimers is described. The new molecules are linked at position 17alpha of the steroid nucleus with either an alkyl chain or a polyethylene glycol chain. They are made from estrone in only five chemical steps with an ove...

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Veröffentlicht in:	Steroids 2006-10, Vol.71 (10), p.911-921
Hauptverfasser:	Bérubé, Gervais, Rabouin, Daniel, Perron, Valérie, N'Zemba, Blaise, Gaudreault, René-C, Parent, Sophie, Asselin, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast Neoplasms Cell Line, Tumor Dimerization Estradiol - chemical synthesis Estradiol - chemistry Estradiol - pharmacology Estrogen Receptor alpha - metabolism Estrogen Receptor beta - metabolism Humans Intestinal Neoplasms Magnetic Resonance Spectroscopy Protein Binding Skin Neoplasms Spectrophotometry, Infrared
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