Selective modulation of the CAP/Cbl pathway in the adipose tissue of high fat diet treated rats

A high-fat diet (HFD) is associated with reduced glucose uptake in muscle, but not in adipose tissue. In the present study, we investigated whether a HFD can modulate glucose uptake in adipose tissue by increasing signal transduction through the CAP/Cbl pathway, independently of the PI3-K/Akt pathwa...

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Veröffentlicht in:	FEBS letters 2006-09, Vol.580 (20), p.4889-4894
Hauptverfasser:	Prada, Patrícia Oliveira, Pauli, José Rodrigo, Ropelle, Eduardo Rochete, Zecchin, Henrique Gottardello, Carvalheira, José Barreto Campello, Velloso, Lício Augusto, Saad, Mario José Abdalla
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Adipose Tissue - metabolism Akt Animals CAP Cbl Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism Dietary Fats - administration & dosage Glucose - metabolism GLUT4 High-fat diet Insulin - metabolism Male Muscle, Skeletal - metabolism Oncogene Protein v-cbl - genetics Oncogene Protein v-cbl - metabolism Phosphatidylinositol 3-Kinases - metabolism PI3-K Rat Rats Rats, Wistar Signal Transduction - physiology Skeletal muscle
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