Activation of Tie2 by angiopoietin-1 and angiopoietin-2 results in their release and receptor internalization

The receptor tyrosine kinase Tie2 is highly expressed in endothelial cells and is crucial for angiogenesis and vascular maintenance. The ligands for Tie2 are the angiopoietins, of which angiopoietin-1 and angiopoietin-2 have been the most studied. Angiopoietin-1 has been characterized as the primary...

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Veröffentlicht in:	Journal of cell science 2006-09, Vol.119 (Pt 17), p.3551-3560
Hauptverfasser:	Bogdanovic, Elena, Nguyen, Vicky P K H, Dumont, Daniel J
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiopoietin-1 - genetics Angiopoietin-1 - metabolism Angiopoietin-2 - genetics Angiopoietin-2 - metabolism Animals Cells, Cultured Endocytosis - physiology Endothelial Cells - cytology Endothelial Cells - physiology Enzyme Activation Humans Ligands Radioligand Assay Receptor, TIE-2 - genetics Receptor, TIE-2 - metabolism
Online-Zugang:	Volltext
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