In Vivo Biocombinatorial Synthesis of Lipopeptides by COM Domain-Mediated Reprogramming of the Surfactin Biosynthetic Complex

The intermolecular communication within NRPS complexes relies on the coordinated interplay of donor and acceptor communication-mediating (COM) domains. In this study, the potential of COM domains was exploited in vivo by establishing a system for the true biocombinatorial synthesis of lipopeptides v...

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Veröffentlicht in:	Chemistry & biology 2006-08, Vol.13 (8), p.899-908
Hauptverfasser:	Chiocchini, Claudia, Linne, Uwe, Stachelhaus, Torsten
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacillus subtilis - chemistry Bacillus subtilis - enzymology Bacillus subtilis - metabolism Lipopeptides Lipoproteins - biosynthesis Lipoproteins - chemistry Lipoproteins - physiology Molecular Conformation Peptide Biosynthesis Peptide Synthases - chemistry Peptide Synthases - metabolism Peptides, Cyclic - chemistry Peptides, Cyclic - physiology Protein Binding Structure-Activity Relationship
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