A MODEL FOR NATURAL IMMUNITY TO ASEXUAL BLOOD STAGES OF PLASMODIUM FALCIPARUM MALARIA IN ENDEMIC AREAS
Most mathematical models for acquired immunity to Plasmodium falciparum consider effects of immunity on duration of infection and infectiousness, but do not consider the most evident effect of immunity, which is to reduce parasite densities. Few attempts have been made to fit such models to field da...
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| Veröffentlicht in: | The American journal of tropical medicine and hygiene 2006-08, Vol.75 (2 suppl), p.19-31 |
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| container_issue | 2 suppl |
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| container_title | The American journal of tropical medicine and hygiene |
| container_volume | 75 |
| creator | MAIRE, NICOLAS SMITH, THOMAS ROSS, AMANDA OWUSU-AGYEI, SETH DIETZ, KLAUS MOLINEAUX, LOUIS |
| description | Most mathematical models for acquired immunity to Plasmodium falciparum consider effects of immunity on duration of infection and infectiousness, but do not consider the most evident effect of immunity, which is to reduce parasite densities. Few attempts have been made to fit such models to field data. We propose a stochastic simulation model to predict the distributions of P. falciparum parasite densities in endemic areas, in which acquired immunity acts by reducing parasite densities. We have fitted this model to age-specific prevalence and geometric mean densities from settings in Ghana, Nigeria, and Tanzania. The model appears to reproduce reasonably well the parasitologic patterns seen in malariologic surveys in endemic areas and is appropriate for predicting the impact of interventions such as vaccination in the context of continual exposure to P. falciparum. |
| doi_str_mv | 10.4269/ajtmh.2006.75.19 |
| format | Article |
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| subjects | Adolescent Adult Aging Animals Biological and medical sciences Child Child, Preschool Ghana - epidemiology Human protozoal diseases Humans Infant Infectious diseases Malaria Malaria, Falciparum - blood Malaria, Falciparum - epidemiology Malaria, Falciparum - immunology Malaria, Falciparum - parasitology Medical sciences Middle Aged Models, Biological Models, Statistical Nigeria - epidemiology Parasitic diseases Plasmodium falciparum Plasmodium falciparum - growth & development Plasmodium falciparum - immunology Prevalence Protozoal diseases Tanzania - epidemiology |
| title | A MODEL FOR NATURAL IMMUNITY TO ASEXUAL BLOOD STAGES OF PLASMODIUM FALCIPARUM MALARIA IN ENDEMIC AREAS |
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