Neuroscience: rewiring the adult brain
Any analysis of plastic reorganization at a neuronal locus needs a veridical measure of changes in the functional output--that is, spiking responses of the neurons in question. In a study of the effect of retinal lesions on adult primary visual cortex (V1), Smirnakis et al. propose that there is no...
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| Veröffentlicht in: | Nature 2005-11, Vol.438 (7065), p.E3; discussion E3-E3 |
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| container_issue | 7065 |
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| container_title | Nature |
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| creator | Calford, Michael B Chino, Yuzo M Das, Aniruddha Eysel, Ulf T Gilbert, Charles D Heinen, Stephen J Kaas, Jon H Ullman, Shimon |
| description | Any analysis of plastic reorganization at a neuronal locus needs a veridical measure of changes in the functional output--that is, spiking responses of the neurons in question. In a study of the effect of retinal lesions on adult primary visual cortex (V1), Smirnakis et al. propose that there is no cortical reorganization. Their results are based, however, on BOLD (blood-oxygen-level-dependent) fMRI (functional magnetic resonance imaging), which provides an unreliable gauge of spiking activity. We therefore question their criterion for lack of plasticity, particularly in the light of the large body of earlier work that demonstrates cortical plasticity. |
| doi_str_mv | 10.1038/nature04359 |
| format | Article |
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| subjects | Action Potentials - physiology Adult Animals Humans Macaca - physiology Magnetic Resonance Imaging Neuronal Plasticity - physiology Reproducibility of Results Retina - injuries Retina - physiology Visual Cortex - physiology |
| title | Neuroscience: rewiring the adult brain |
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