Infections with human herpesvirus 6 variant B delay platelet engraftment after allogeneic haematopoietic stem cell transplantation
Summary The clinical significance of human herpesvirus (HHV‐6) infections after allogeneic stem cell transplantation (SCT) remains controversial. We analysed cryoconserved plasma samples from 82 patients after allogeneic SCT by quantitative polymerase chain reaction for HHV‐6 variants A and B. Plate...
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| Veröffentlicht in: | British journal of haematology 2005-11, Vol.131 (4), p.480-482 |
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| container_title | British journal of haematology |
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| creator | Radonić, Aleksandar Oswald, Olivia Thulke, Stefanie Brockhaus, Nina Nitsche, Andreas Siegert, Wolfgang Schetelig, Johannes |
| description | Summary
The clinical significance of human herpesvirus (HHV‐6) infections after allogeneic stem cell transplantation (SCT) remains controversial. We analysed cryoconserved plasma samples from 82 patients after allogeneic SCT by quantitative polymerase chain reaction for HHV‐6 variants A and B. Platelet engraftment was delayed in patients with HHV‐6B infections but not with HHV‐6A infections detected before day +28. In multivariate analysis early HHV‐6B infections and the type of conditioning were associated with platelet engraftment. In conclusion, the two variants of HHV‐6 should be studied separately; early infections with HHV‐6B may contribute to delayed platelet engraftment after allogeneic SCT. |
| doi_str_mv | 10.1111/j.1365-2141.2005.05788.x |
| format | Article |
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The clinical significance of human herpesvirus (HHV‐6) infections after allogeneic stem cell transplantation (SCT) remains controversial. We analysed cryoconserved plasma samples from 82 patients after allogeneic SCT by quantitative polymerase chain reaction for HHV‐6 variants A and B. Platelet engraftment was delayed in patients with HHV‐6B infections but not with HHV‐6A infections detected before day +28. In multivariate analysis early HHV‐6B infections and the type of conditioning were associated with platelet engraftment. In conclusion, the two variants of HHV‐6 should be studied separately; early infections with HHV‐6B may contribute to delayed platelet engraftment after allogeneic SCT.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1111/j.1365-2141.2005.05788.x</identifier><identifier>PMID: 16281938</identifier><identifier>CODEN: BJHEAL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adolescent ; Adult ; allogeneic stem cell transplantation ; Biological and medical sciences ; Blood Platelets - physiology ; DNA, Viral - blood ; Female ; Graft Survival ; Graft vs Host Disease - virology ; Hematologic and hematopoietic diseases ; Hematopoietic Stem Cell Transplantation ; Herpesvirus 6, Human - classification ; Herpesvirus 6, Human - isolation & purification ; human herpesvirus 6 ; Humans ; Male ; Medical sciences ; Middle Aged ; platelet engraftment ; Polymerase Chain Reaction - methods ; quantitative polymerase chain reaction ; Retrospective Studies ; Roseolovirus Infections - blood ; Roseolovirus Infections - complications ; Roseolovirus Infections - virology ; Transplantation Conditioning - methods ; variant B</subject><ispartof>British journal of haematology, 2005-11, Vol.131 (4), p.480-482</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4478-4791caa23b290d5398cbedd9ddc6fe3d149a440350c1df0a081cf7ab74e4e5bc3</citedby><cites>FETCH-LOGICAL-c4478-4791caa23b290d5398cbedd9ddc6fe3d149a440350c1df0a081cf7ab74e4e5bc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2141.2005.05788.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2141.2005.05788.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17239521$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16281938$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Radonić, Aleksandar</creatorcontrib><creatorcontrib>Oswald, Olivia</creatorcontrib><creatorcontrib>Thulke, Stefanie</creatorcontrib><creatorcontrib>Brockhaus, Nina</creatorcontrib><creatorcontrib>Nitsche, Andreas</creatorcontrib><creatorcontrib>Siegert, Wolfgang</creatorcontrib><creatorcontrib>Schetelig, Johannes</creatorcontrib><title>Infections with human herpesvirus 6 variant B delay platelet engraftment after allogeneic haematopoietic stem cell transplantation</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>Summary
The clinical significance of human herpesvirus (HHV‐6) infections after allogeneic stem cell transplantation (SCT) remains controversial. We analysed cryoconserved plasma samples from 82 patients after allogeneic SCT by quantitative polymerase chain reaction for HHV‐6 variants A and B. Platelet engraftment was delayed in patients with HHV‐6B infections but not with HHV‐6A infections detected before day +28. In multivariate analysis early HHV‐6B infections and the type of conditioning were associated with platelet engraftment. In conclusion, the two variants of HHV‐6 should be studied separately; early infections with HHV‐6B may contribute to delayed platelet engraftment after allogeneic SCT.</description><subject>Adolescent</subject><subject>Adult</subject><subject>allogeneic stem cell transplantation</subject><subject>Biological and medical sciences</subject><subject>Blood Platelets - physiology</subject><subject>DNA, Viral - blood</subject><subject>Female</subject><subject>Graft Survival</subject><subject>Graft vs Host Disease - virology</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematopoietic Stem Cell Transplantation</subject><subject>Herpesvirus 6, Human - classification</subject><subject>Herpesvirus 6, Human - isolation & purification</subject><subject>human herpesvirus 6</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>platelet engraftment</subject><subject>Polymerase Chain Reaction - methods</subject><subject>quantitative polymerase chain reaction</subject><subject>Retrospective Studies</subject><subject>Roseolovirus Infections - blood</subject><subject>Roseolovirus Infections - complications</subject><subject>Roseolovirus Infections - virology</subject><subject>Transplantation Conditioning - methods</subject><subject>variant B</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtv1DAQgC1ERZfCX0C-wC3Bjp3EOXCgFdBWlbjA2Zo4k65XzgPbabtXfnmd7qq91pfxaL556COEcpbz9L7uci6qMiu45HnBWJmzslYqf3hDNs-Ft2TDGKszzqQ6Je9D2DHGBSv5O3LKq0LxRqgN-X819miincZA723c0u0ywEi36GcMd9YvgVb0DryFMdJz2qGDPZ0dRHQYKY63Hvo4YCqmiJ6Cc9MtjmgN3QIOEKd5shhTGiIO1KBzNHoYQ5oxRlgXfyAnPbiAH4_xjPz9-ePPxWV28_vX1cX3m8xIWatM1g03AIVoi4Z1pWiUabHrmq4zVY-i47IBKZkomeFdz4Apbvoa2lqixLI14ox8Ocyd_fRvwRD1YMN6EIw4LUFXKjkUvE6gOoDGTyF47PXs7QB-rznTq3-906tmvWrWq3_95F8_pNZPxx1LO2D30ngUnoDPRwCCAdcnFcaGF64uRFMWPHHfDty9dbh_9QH6_Ppy_YlHbBmkqw</recordid><startdate>200511</startdate><enddate>200511</enddate><creator>Radonić, Aleksandar</creator><creator>Oswald, Olivia</creator><creator>Thulke, Stefanie</creator><creator>Brockhaus, Nina</creator><creator>Nitsche, Andreas</creator><creator>Siegert, Wolfgang</creator><creator>Schetelig, Johannes</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200511</creationdate><title>Infections with human herpesvirus 6 variant B delay platelet engraftment after allogeneic haematopoietic stem cell transplantation</title><author>Radonić, Aleksandar ; Oswald, Olivia ; Thulke, Stefanie ; Brockhaus, Nina ; Nitsche, Andreas ; Siegert, Wolfgang ; Schetelig, Johannes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4478-4791caa23b290d5398cbedd9ddc6fe3d149a440350c1df0a081cf7ab74e4e5bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>allogeneic stem cell transplantation</topic><topic>Biological and medical sciences</topic><topic>Blood Platelets - physiology</topic><topic>DNA, Viral - blood</topic><topic>Female</topic><topic>Graft Survival</topic><topic>Graft vs Host Disease - virology</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematopoietic Stem Cell Transplantation</topic><topic>Herpesvirus 6, Human - classification</topic><topic>Herpesvirus 6, Human - isolation & purification</topic><topic>human herpesvirus 6</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>platelet engraftment</topic><topic>Polymerase Chain Reaction - methods</topic><topic>quantitative polymerase chain reaction</topic><topic>Retrospective Studies</topic><topic>Roseolovirus Infections - blood</topic><topic>Roseolovirus Infections - complications</topic><topic>Roseolovirus Infections - virology</topic><topic>Transplantation Conditioning - methods</topic><topic>variant B</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Radonić, Aleksandar</creatorcontrib><creatorcontrib>Oswald, Olivia</creatorcontrib><creatorcontrib>Thulke, Stefanie</creatorcontrib><creatorcontrib>Brockhaus, Nina</creatorcontrib><creatorcontrib>Nitsche, Andreas</creatorcontrib><creatorcontrib>Siegert, Wolfgang</creatorcontrib><creatorcontrib>Schetelig, Johannes</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Radonić, Aleksandar</au><au>Oswald, Olivia</au><au>Thulke, Stefanie</au><au>Brockhaus, Nina</au><au>Nitsche, Andreas</au><au>Siegert, Wolfgang</au><au>Schetelig, Johannes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Infections with human herpesvirus 6 variant B delay platelet engraftment after allogeneic haematopoietic stem cell transplantation</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>2005-11</date><risdate>2005</risdate><volume>131</volume><issue>4</issue><spage>480</spage><epage>482</epage><pages>480-482</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><coden>BJHEAL</coden><abstract>Summary
The clinical significance of human herpesvirus (HHV‐6) infections after allogeneic stem cell transplantation (SCT) remains controversial. We analysed cryoconserved plasma samples from 82 patients after allogeneic SCT by quantitative polymerase chain reaction for HHV‐6 variants A and B. Platelet engraftment was delayed in patients with HHV‐6B infections but not with HHV‐6A infections detected before day +28. In multivariate analysis early HHV‐6B infections and the type of conditioning were associated with platelet engraftment. In conclusion, the two variants of HHV‐6 should be studied separately; early infections with HHV‐6B may contribute to delayed platelet engraftment after allogeneic SCT.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>16281938</pmid><doi>10.1111/j.1365-2141.2005.05788.x</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult allogeneic stem cell transplantation Biological and medical sciences Blood Platelets - physiology DNA, Viral - blood Female Graft Survival Graft vs Host Disease - virology Hematologic and hematopoietic diseases Hematopoietic Stem Cell Transplantation Herpesvirus 6, Human - classification Herpesvirus 6, Human - isolation & purification human herpesvirus 6 Humans Male Medical sciences Middle Aged platelet engraftment Polymerase Chain Reaction - methods quantitative polymerase chain reaction Retrospective Studies Roseolovirus Infections - blood Roseolovirus Infections - complications Roseolovirus Infections - virology Transplantation Conditioning - methods variant B |
| title | Infections with human herpesvirus 6 variant B delay platelet engraftment after allogeneic haematopoietic stem cell transplantation |
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