Caspase-independent induction of apoptosis in human melanoma cells by the proapoptotic Bcl-2-related protein Nbk Bik

The proapoptotic BH3-only protein natural born killer / Bcl-2 interacting killer (Nbk / Bik) has been described to inhibit Bcl-2 and Bcl-x L , thereby supporting the death promoting ability of Bax. In order to evaluate its function in melanoma, we investigated the response after Nbk / Bik overexpres...

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Veröffentlicht in:	Oncogene 2005-11, Vol.24 (49), p.7369-7380
Hauptverfasser:	Oppermann, Malte, Geilen, Christoph C, Fecker, Lothar F, Gillissen, Bernhard, Daniel, Peter T, Eberle, Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	Ageing, cell death Animals Anti-Inflammatory Agents - pharmacology Antibiotics, Antineoplastic - pharmacology Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Bax protein bcl-2 Homologous Antagonist-Killer Protein - metabolism Bcl-2 protein bcl-2-Associated X Protein - metabolism Bcl-x protein Biological and medical sciences Bisphosphonates Caspase Caspases - metabolism CD95 antigen Cell Biology Cell death Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chromatin Chromatin - metabolism Cytochrome c Cytochromes c - metabolism Dermatology Diphosphonates - pharmacology DNA fragmentation Doxorubicin Doxorubicin - pharmacology Doxycycline Drug Resistance, Neoplasm Etoposide Etoposide - pharmacology fas Receptor - metabolism Female Flow Cytometry Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Neoplastic Human Genetics Humans In Situ Nick-End Labeling Injections, Subcutaneous Internal Medicine Medical sciences Medicine Medicine & Public Health Melanoma Melanoma - drug therapy Melanoma - metabolism Melanoma - pathology Mice Mice, Inbred BALB C Mice, Nude Molecular and cellular biology mRNA Oncology original-paper Pamidronic acid Protein Synthesis Inhibitors - pharmacology Proteins Proto-Oncogene Proteins c-bcl-2 - metabolism Skin - metabolism Tetracycline - pharmacology Tumor Cells, Cultured Tumors Tumors of the skin and soft tissue. Premalignant lesions
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