Dose-response impact of various tocotrienols on serum lipid parameters in 5-week-old female chickens
The cholesterol-suppressive action of the tocotrienol-rich-fraction (TRF) of palm oil may be due to the effect of its constituent tocotrienols on β-hydroxy-β-methylglutaryl coenzyme A (HMG-CoA) reductase activity. The tocotrienols modulate HMG-CoA reductase activity via a post-transcriptional mechan...
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| creator | Yu, S.G Thomas, A.M Gapor, A Tan, B Qureshi, N Qureshi, A.A |
| description | The cholesterol-suppressive action of the tocotrienol-rich-fraction (TRF) of palm oil may be due to the effect of its constituent tocotrienols on β-hydroxy-β-methylglutaryl coenzyme A (HMG-CoA) reductase activity. The tocotrienols modulate HMG-CoA reductase activity via a post-transcriptional mechanism. As a consequence small doses (5-200 ppm) of TRF-supplemented diets fed to experimental animals lower serum cholesterol levels. These findings led us to evaluate the safety and efficacy of large supplements of TRF and its constituents. Diets supplemented with 50, 100, 250, 500, 1,000, or 2,000 ppm of TRF, α-tocopherol, α-tocotrienol, γ-tocotrienol, or δ-tocotrienol were fed to chickens for 4 wk. There were no differences between groups or within groups in weight gain, or in feed consumption at the termination of the feeding period. Supplemental TRF produced a dose-response (50-2,000 ppm) lowering of serum total and LDL cholesterol levels of 22% and 52% (P |
| doi_str_mv | 10.1007/s11745-006-5119-1 |
| format | Article |
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The tocotrienols modulate HMG-CoA reductase activity via a post-transcriptional mechanism. As a consequence small doses (5-200 ppm) of TRF-supplemented diets fed to experimental animals lower serum cholesterol levels. These findings led us to evaluate the safety and efficacy of large supplements of TRF and its constituents. Diets supplemented with 50, 100, 250, 500, 1,000, or 2,000 ppm of TRF, α-tocopherol, α-tocotrienol, γ-tocotrienol, or δ-tocotrienol were fed to chickens for 4 wk. There were no differences between groups or within groups in weight gain, or in feed consumption at the termination of the feeding period. Supplemental TRF produced a dose-response (50-2,000 ppm) lowering of serum total and LDL cholesterol levels of 22% and 52% (P<0.05), respectively, compared with the control group. α-Tocopherol did not affect total or LDL-cholesterol levels. Supplemental α-tocotrienol within the 50-500 ppm range produced a dose-response lowering of total (17%) and LDL (33%) cholesterol levels. The more potent γ and δ isomers yielded dose-response (50-2,000 ppm) reductions of serum total (32%) and LDL (66%) cholesterol levels. HDL cholesterol levels were minimally impacted by the tocotrienols; as a result, the HDL/LDL cholesterol ratios were markedly improved (123-150%) by the supplements. Serum triglyceride levels were significantly lower in sera of pullets receiving the higher supplements. The safe dose of various tocotrienols for human consumption might be 200-1,000 mg/d based on this study.</description><identifier>ISSN: 0024-4201</identifier><identifier>EISSN: 1558-9307</identifier><identifier>DOI: 10.1007/s11745-006-5119-1</identifier><identifier>PMID: 16933790</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer‐Verlag</publisher><subject>alpha-tocopherol ; alpha-Tocopherol - administration & dosage ; alpha-Tocopherol - metabolism ; alpha-Tocopherol - pharmacology ; Analysis of Variance ; Animals ; blood lipids ; Chickens ; Chickens - blood ; Chickens - metabolism ; Cholesterol ; Cholesterol - blood ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; dose response ; Dose-Response Relationship, Drug ; feed intake ; feed supplements ; Female ; high density lipoprotein ; human health ; hypercholesterolemia ; Hypercholesterolemia - diet therapy ; isomers ; Lipid Metabolism - drug effects ; Lipids - blood ; low density lipoprotein ; Palm Oil ; Plant Oils - administration & dosage ; Plant Oils - chemistry ; Plant Oils - pharmacology ; tocotrienols ; Tocotrienols - administration & dosage ; Tocotrienols - metabolism ; Tocotrienols - pharmacology ; triacylglycerols ; Vitamin E - administration & dosage ; Vitamin E - analogs & derivatives ; Vitamin E - metabolism ; Vitamin E - pharmacology ; weight gain</subject><ispartof>Lipids, 2006-05, Vol.41 (5), p.453-461</ispartof><rights>2006 American Oil Chemists' Society (AOCS)</rights><rights>Copyright AOCS Press May 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5079-779cb577f118775e8f76c26b508fefc80b26d86cc63d00bc71f974c57cf34a573</citedby><cites>FETCH-LOGICAL-c5079-779cb577f118775e8f76c26b508fefc80b26d86cc63d00bc71f974c57cf34a573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1007%2Fs11745-006-5119-1$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1007%2Fs11745-006-5119-1$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16933790$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, S.G</creatorcontrib><creatorcontrib>Thomas, A.M</creatorcontrib><creatorcontrib>Gapor, A</creatorcontrib><creatorcontrib>Tan, B</creatorcontrib><creatorcontrib>Qureshi, N</creatorcontrib><creatorcontrib>Qureshi, A.A</creatorcontrib><title>Dose-response impact of various tocotrienols on serum lipid parameters in 5-week-old female chickens</title><title>Lipids</title><addtitle>Lipids</addtitle><description>The cholesterol-suppressive action of the tocotrienol-rich-fraction (TRF) of palm oil may be due to the effect of its constituent tocotrienols on β-hydroxy-β-methylglutaryl coenzyme A (HMG-CoA) reductase activity. The tocotrienols modulate HMG-CoA reductase activity via a post-transcriptional mechanism. As a consequence small doses (5-200 ppm) of TRF-supplemented diets fed to experimental animals lower serum cholesterol levels. These findings led us to evaluate the safety and efficacy of large supplements of TRF and its constituents. Diets supplemented with 50, 100, 250, 500, 1,000, or 2,000 ppm of TRF, α-tocopherol, α-tocotrienol, γ-tocotrienol, or δ-tocotrienol were fed to chickens for 4 wk. There were no differences between groups or within groups in weight gain, or in feed consumption at the termination of the feeding period. Supplemental TRF produced a dose-response (50-2,000 ppm) lowering of serum total and LDL cholesterol levels of 22% and 52% (P<0.05), respectively, compared with the control group. α-Tocopherol did not affect total or LDL-cholesterol levels. Supplemental α-tocotrienol within the 50-500 ppm range produced a dose-response lowering of total (17%) and LDL (33%) cholesterol levels. The more potent γ and δ isomers yielded dose-response (50-2,000 ppm) reductions of serum total (32%) and LDL (66%) cholesterol levels. HDL cholesterol levels were minimally impacted by the tocotrienols; as a result, the HDL/LDL cholesterol ratios were markedly improved (123-150%) by the supplements. Serum triglyceride levels were significantly lower in sera of pullets receiving the higher supplements. The safe dose of various tocotrienols for human consumption might be 200-1,000 mg/d based on this study.</description><subject>alpha-tocopherol</subject><subject>alpha-Tocopherol - administration & dosage</subject><subject>alpha-Tocopherol - metabolism</subject><subject>alpha-Tocopherol - pharmacology</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>blood lipids</subject><subject>Chickens</subject><subject>Chickens - blood</subject><subject>Chickens - metabolism</subject><subject>Cholesterol</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>dose response</subject><subject>Dose-Response Relationship, Drug</subject><subject>feed intake</subject><subject>feed supplements</subject><subject>Female</subject><subject>high density lipoprotein</subject><subject>human health</subject><subject>hypercholesterolemia</subject><subject>Hypercholesterolemia - diet therapy</subject><subject>isomers</subject><subject>Lipid Metabolism - drug effects</subject><subject>Lipids - blood</subject><subject>low density lipoprotein</subject><subject>Palm Oil</subject><subject>Plant Oils - administration & dosage</subject><subject>Plant Oils - chemistry</subject><subject>Plant Oils - pharmacology</subject><subject>tocotrienols</subject><subject>Tocotrienols - administration & dosage</subject><subject>Tocotrienols - metabolism</subject><subject>Tocotrienols - pharmacology</subject><subject>triacylglycerols</subject><subject>Vitamin E - administration & dosage</subject><subject>Vitamin E - analogs & derivatives</subject><subject>Vitamin E - metabolism</subject><subject>Vitamin E - pharmacology</subject><subject>weight gain</subject><issn>0024-4201</issn><issn>1558-9307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU1vFSEUhonR2Gv1B7hR4sIdCsPAGZam9aPJTTTRrgmXOSjtzDDCTJv-e7mZm5i4ccUhed43hwdCXgr-TnAO74sQ0CrGuWZKCMPEI7ITSnXMSA6PyY7zpmVtw8UZeVbKTb2K1qin5ExoIyUYviP9ZSrIMpY5TQVpHGfnF5oCvXM5prXQJfm05IhTGgpNEy2Y15EOcY49nV12Iy6YC40TVewe8ZaloacBRzcg9b-iv8WpPCdPghsKvjid5-T608cfF1_Y_uvnq4sPe-YVB8MAjD8ogCBEB6CwC6B9ow-KdwGD7_ih0X2nvdey5_zgQQQDrVfgg2ydAnlO3m69c06_VyyLHWPxOAxuwvoWqzvotGm6Cr75B7xJa57qbraBVksjGl0hsUE-p1IyBjvnOLr8YAW3R_9282-rf3v0b0XNvDoVr4cR-7-Jk_AKwAbcxwEf_t9o91ffLo9jTb7eksEl637mWOz19_q3kgtulGmk_APGhJoJ</recordid><startdate>200605</startdate><enddate>200605</enddate><creator>Yu, S.G</creator><creator>Thomas, A.M</creator><creator>Gapor, A</creator><creator>Tan, B</creator><creator>Qureshi, N</creator><creator>Qureshi, A.A</creator><general>Springer‐Verlag</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>200605</creationdate><title>Dose-response impact of various tocotrienols on serum lipid parameters in 5-week-old female chickens</title><author>Yu, S.G ; Thomas, A.M ; Gapor, A ; Tan, B ; Qureshi, N ; Qureshi, A.A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5079-779cb577f118775e8f76c26b508fefc80b26d86cc63d00bc71f974c57cf34a573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>alpha-tocopherol</topic><topic>alpha-Tocopherol - administration & dosage</topic><topic>alpha-Tocopherol - metabolism</topic><topic>alpha-Tocopherol - pharmacology</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>blood lipids</topic><topic>Chickens</topic><topic>Chickens - blood</topic><topic>Chickens - metabolism</topic><topic>Cholesterol</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>dose response</topic><topic>Dose-Response Relationship, Drug</topic><topic>feed intake</topic><topic>feed supplements</topic><topic>Female</topic><topic>high density lipoprotein</topic><topic>human health</topic><topic>hypercholesterolemia</topic><topic>Hypercholesterolemia - diet therapy</topic><topic>isomers</topic><topic>Lipid Metabolism - drug effects</topic><topic>Lipids - blood</topic><topic>low density lipoprotein</topic><topic>Palm Oil</topic><topic>Plant Oils - administration & dosage</topic><topic>Plant Oils - chemistry</topic><topic>Plant Oils - pharmacology</topic><topic>tocotrienols</topic><topic>Tocotrienols - administration & dosage</topic><topic>Tocotrienols - metabolism</topic><topic>Tocotrienols - pharmacology</topic><topic>triacylglycerols</topic><topic>Vitamin E - administration & dosage</topic><topic>Vitamin E - analogs & derivatives</topic><topic>Vitamin E - metabolism</topic><topic>Vitamin E - pharmacology</topic><topic>weight gain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, S.G</creatorcontrib><creatorcontrib>Thomas, A.M</creatorcontrib><creatorcontrib>Gapor, A</creatorcontrib><creatorcontrib>Tan, B</creatorcontrib><creatorcontrib>Qureshi, N</creatorcontrib><creatorcontrib>Qureshi, A.A</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Lipids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, S.G</au><au>Thomas, A.M</au><au>Gapor, A</au><au>Tan, B</au><au>Qureshi, N</au><au>Qureshi, A.A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dose-response impact of various tocotrienols on serum lipid parameters in 5-week-old female chickens</atitle><jtitle>Lipids</jtitle><addtitle>Lipids</addtitle><date>2006-05</date><risdate>2006</risdate><volume>41</volume><issue>5</issue><spage>453</spage><epage>461</epage><pages>453-461</pages><issn>0024-4201</issn><eissn>1558-9307</eissn><abstract>The cholesterol-suppressive action of the tocotrienol-rich-fraction (TRF) of palm oil may be due to the effect of its constituent tocotrienols on β-hydroxy-β-methylglutaryl coenzyme A (HMG-CoA) reductase activity. The tocotrienols modulate HMG-CoA reductase activity via a post-transcriptional mechanism. As a consequence small doses (5-200 ppm) of TRF-supplemented diets fed to experimental animals lower serum cholesterol levels. These findings led us to evaluate the safety and efficacy of large supplements of TRF and its constituents. Diets supplemented with 50, 100, 250, 500, 1,000, or 2,000 ppm of TRF, α-tocopherol, α-tocotrienol, γ-tocotrienol, or δ-tocotrienol were fed to chickens for 4 wk. There were no differences between groups or within groups in weight gain, or in feed consumption at the termination of the feeding period. Supplemental TRF produced a dose-response (50-2,000 ppm) lowering of serum total and LDL cholesterol levels of 22% and 52% (P<0.05), respectively, compared with the control group. α-Tocopherol did not affect total or LDL-cholesterol levels. Supplemental α-tocotrienol within the 50-500 ppm range produced a dose-response lowering of total (17%) and LDL (33%) cholesterol levels. The more potent γ and δ isomers yielded dose-response (50-2,000 ppm) reductions of serum total (32%) and LDL (66%) cholesterol levels. HDL cholesterol levels were minimally impacted by the tocotrienols; as a result, the HDL/LDL cholesterol ratios were markedly improved (123-150%) by the supplements. Serum triglyceride levels were significantly lower in sera of pullets receiving the higher supplements. The safe dose of various tocotrienols for human consumption might be 200-1,000 mg/d based on this study.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer‐Verlag</pub><pmid>16933790</pmid><doi>10.1007/s11745-006-5119-1</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Lipids, 2006-05, Vol.41 (5), p.453-461 |
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| subjects | alpha-tocopherol alpha-Tocopherol - administration & dosage alpha-Tocopherol - metabolism alpha-Tocopherol - pharmacology Analysis of Variance Animals blood lipids Chickens Chickens - blood Chickens - metabolism Cholesterol Cholesterol - blood Cholesterol, HDL - blood Cholesterol, LDL - blood dose response Dose-Response Relationship, Drug feed intake feed supplements Female high density lipoprotein human health hypercholesterolemia Hypercholesterolemia - diet therapy isomers Lipid Metabolism - drug effects Lipids - blood low density lipoprotein Palm Oil Plant Oils - administration & dosage Plant Oils - chemistry Plant Oils - pharmacology tocotrienols Tocotrienols - administration & dosage Tocotrienols - metabolism Tocotrienols - pharmacology triacylglycerols Vitamin E - administration & dosage Vitamin E - analogs & derivatives Vitamin E - metabolism Vitamin E - pharmacology weight gain |
| title | Dose-response impact of various tocotrienols on serum lipid parameters in 5-week-old female chickens |
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