Cyclosporine-Loaded Microspheres for Treatment of Uveitis: In Vitro Characterization and In Vivo Pharmacokinetic Study

A sustained intraocular level of immunosuppressive drug is desirable for the treatment of uveitis and other intraocular immune disorders. The objective of the present investigation was to assess the suitability of cyclosporine-loaded poly(lactic-co-glycolic acid) microspheres (CyS-PLGA-MS) to achiev...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2006-09, Vol.47 (9), p.3983-3988
Hauptverfasser:	He, Yuan, Liu, Yuling, Liu, Yu, Wang, Jiancheng, Zhang, Xuan, Lu, Wanliang, Ma, Zhizhong, Zhu, Xiuan, Zhang, Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biocompatible Materials - pharmacokinetics Biological and medical sciences Chromatography, High Pressure Liquid Cyclosporine - administration & dosage Cyclosporine - pharmacokinetics Drug Carriers Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - pharmacokinetics Lactic Acid - pharmacokinetics Medical sciences Microscopy, Electron, Scanning Microscopy, Phase-Contrast Microspheres Ophthalmology Particle Size Polyglycolic Acid - pharmacokinetics Polymers - pharmacokinetics Rabbits Surface Properties Uvea diseases Uveitis - drug therapy Vertebrates: nervous system and sense organs Vitreous Body - metabolism
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