Simple estimates of haplotype relative risks in case-control data

Methods of varying complexity have been proposed to efficiently estimate haplotype relative risks in case‐control data. Our goal was to compare methods that estimate associations between disease conditions and common haplotypes in large case‐control studies such that haplotype imputation is done onc...

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Veröffentlicht in:	Genetic epidemiology 2006-09, Vol.30 (6), p.485-494
Hauptverfasser:	French, Benjamin, Lumley, Thomas, Monks, Stephanie A., Rice, Kenneth M., Hindorff, Lucia A., Reiner, Alexander P., Psaty, Bruce M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Biological and medical sciences Case-Control Studies Classical genetics, quantitative genetics, hybrids Computer Simulation Fundamental and applied biological sciences. Psychology gene-environment interaction Genetic Predisposition to Disease Genetics of eukaryotes. Biological and molecular evolution Genotype Haplotypes - genetics Human Humans imputation Incidence Likelihood Functions linkage disequilibrium Models, Genetic phase ambiguity Polymorphism, Single Nucleotide - genetics Renin-Angiotensin System - genetics Risk Factors unphased genotypes weighted logistic regression
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