Biochemical Activity of Reactive Oxygen Species Scavengers Do Not Predict Retinal Ganglion Cell Survival

Retinal ganglion cells (RGCs) die as a result of axonal injury in a variety of optic neuropathies, including glaucoma. Reactive oxygen species (ROS) act as intracellular signaling molecules and initiate apoptosis in nerve growth factor-deprived sympathetic neurons and axotomized RGCs. Determination...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2006-09, Vol.47 (9), p.3878-3886
Hauptverfasser:	Schlieve, Christopher R, Lieven, Christopher J, Levin, Leonard A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - pharmacology Biological and medical sciences Cell Survival Cell-Free System Cells, Cultured Chromans - pharmacology Coculture Techniques Eye and associated structures. Visual pathways and centers. Vision Fluoresceins - metabolism Free Radical Scavengers - pharmacology Fundamental and applied biological sciences. Psychology Hydrogen Peroxide - metabolism Metalloporphyrins - pharmacology Polyethylene Glycols - pharmacology Pregnatrienes - pharmacology Rats Rats, Long-Evans Reactive Oxygen Species - metabolism Retinal Ganglion Cells - drug effects Retinal Ganglion Cells - metabolism Retinal Ganglion Cells - pathology Superoxide Dismutase - pharmacology Superoxides - metabolism Vertebrates: nervous system and sense organs
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