Inhibition of vascular endothelial growth factor (VEGF)-165 and semaphorin 3A–mediated cellular invasion and tumor growth by the VEGF signaling inhibitor ZD4190 in human colon cancer cells and xenografts

We recently showed by DNA microarray analysis that vascular endothelial growth factor (VEGF) receptor (VEGFR) is expressed in HCT8/S11 human colon cancer cells, suggesting that several angiogenic factors may target colon cancer cells themselves. In this study, transcripts encoding the VEGF-165 and s...

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Veröffentlicht in:	Molecular cancer therapeutics 2006-08, Vol.5 (8), p.2070-2077
Hauptverfasser:	Nguyen, Quang-Dé, Rodrigues, Sylvie, Rodrigue, Christelle M, Rivat, Christine, Grijelmo, Clara, Bruyneel, Erik, Emami, Shahin, Attoub, Samir, Gespach, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cisplatin - pharmacology Colonic Neoplasms - drug therapy Colonic Neoplasms - pathology Enzyme Inhibitors - pharmacology Female Humans LNM35 lung cancer cells Lung Neoplasms - drug therapy Lung Neoplasms - pathology MAPK Mice Mice, Nude Mitogen-Activated Protein Kinases - metabolism Neoplasm Invasiveness Neuropilins Piperidines - pharmacology Plexin A Quinazolines - pharmacology Receptors, Vascular Endothelial Growth Factor - drug effects Receptors, Vascular Endothelial Growth Factor - metabolism Rho GTPases Semaphorin-3A - drug effects Semaphorin-3A - metabolism Signal Transduction Triazoles - pharmacology Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor A - metabolism Xenograft Model Antitumor Assays
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