Single DNA molecule stretching in sudden mixed shear and elongational microflows

High-throughput stretching and monitoring of single DNA molecules in continuous elongational flow offers compelling advantages for biotechnology applications such as DNA mapping. However, the polymer dynamics in common microfluidic implementations are typically complicated by shear interactions. The...

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Veröffentlicht in:	Lab on a chip 2006-01, Vol.6 (9), p.1187-1199
Hauptverfasser:	Larson, Jonathan W, Yantz, Gregory R, Zhong, Qun, Charnas, Rebecca, D'Antoni, Christina M, Gallo, Michael V, Gillis, Kimberly A, Neely, Lori A, Phillips, Kevin M, Wong, Gordon G, Gullans, Steven R, Gilmanshin, Rudolf
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteriophage lambda - genetics Benzoxazoles - chemistry Chromosomes, Artificial, Bacterial - chemistry DNA Probes - chemistry DNA, Viral - chemistry Fluorescence Microfluidics - instrumentation Microfluidics - methods Microscopy, Confocal Nucleic Acid Conformation
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