Array comparative genomic hybridization analysis in first-trimester spontaneous abortions with 'normal' karyotypes
Array comparative genomic hybridization (array CGH) analysis was conducted in chorionic villous samples from 20 first‐trimester spontaneous abortions with G‐banding normal chromosomes. A microarray, containing 2,173 BAC clones and covering the whole genome with a 1.5‐Mb resolution, was constructed a...
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| Veröffentlicht in: | American journal of medical genetics. Part A 2006-09, Vol.140A (18), p.1931-1935 |
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| container_end_page | 1935 |
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| container_issue | 18 |
| container_start_page | 1931 |
| container_title | American journal of medical genetics. Part A |
| container_volume | 140A |
| creator | Shimokawa, Osamu Harada, Naoki Miyake, Noriko Satoh, Kanako Mizuguchi, Takeshi Niikawa, Norio Matsumoto, Naomichi |
| description | Array comparative genomic hybridization (array CGH) analysis was conducted in chorionic villous samples from 20 first‐trimester spontaneous abortions with G‐banding normal chromosomes. A microarray, containing 2,173 BAC clones and covering the whole genome with a 1.5‐Mb resolution, was constructed and used in the analysis. Two deletions were identified: a 1.4‐Mb deletion at 3p26.2‐p26.3 and a 13.7‐Mb deletion at 13q32.3‐qter. Reexamination of chromosome preparations from the sample with the 13.7‐Mb deletion documented a mixture of cells with the 13q‐ chromosome and those with 46,XX chromosomes, the latter of which are likely to have been derived from contaminating decidual cells. This left the 1.4‐Mb 3p deletion as the only instance with submicroscopic imbalance detected, giving a frequency of 1 in 19 (5%) G‐banding normal abortions. © 2006 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ajmg.a.31421 |
| format | Article |
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A microarray, containing 2,173 BAC clones and covering the whole genome with a 1.5‐Mb resolution, was constructed and used in the analysis. Two deletions were identified: a 1.4‐Mb deletion at 3p26.2‐p26.3 and a 13.7‐Mb deletion at 13q32.3‐qter. Reexamination of chromosome preparations from the sample with the 13.7‐Mb deletion documented a mixture of cells with the 13q‐ chromosome and those with 46,XX chromosomes, the latter of which are likely to have been derived from contaminating decidual cells. This left the 1.4‐Mb 3p deletion as the only instance with submicroscopic imbalance detected, giving a frequency of 1 in 19 (5%) G‐banding normal abortions. © 2006 Wiley‐Liss, Inc.</description><identifier>ISSN: 1552-4825</identifier><identifier>EISSN: 1552-4833</identifier><identifier>DOI: 10.1002/ajmg.a.31421</identifier><identifier>PMID: 16906550</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Abortion, Spontaneous - genetics ; array CGH ; Biological and medical sciences ; chromosomal aberrations ; Chromosome Aberrations ; Chromosome Deletion ; Chromosomes, Artificial, Bacterial - genetics ; Chromosomes, Human, Pair 13 - genetics ; Chromosomes, Human, Pair 3 - genetics ; Diseases of mother, fetus and pregnancy ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Karyotyping ; Medical sciences ; microarray comparative genomic hybridization ; Nucleic Acid Hybridization ; Oligonucleotide Array Sequence Analysis ; Pregnancy ; Pregnancy Trimester, First - genetics ; Pregnancy. Fetus. Placenta ; spontaneous abortion</subject><ispartof>American journal of medical genetics. 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Part A</title><addtitle>Am. J. Med. Genet</addtitle><description>Array comparative genomic hybridization (array CGH) analysis was conducted in chorionic villous samples from 20 first‐trimester spontaneous abortions with G‐banding normal chromosomes. A microarray, containing 2,173 BAC clones and covering the whole genome with a 1.5‐Mb resolution, was constructed and used in the analysis. Two deletions were identified: a 1.4‐Mb deletion at 3p26.2‐p26.3 and a 13.7‐Mb deletion at 13q32.3‐qter. Reexamination of chromosome preparations from the sample with the 13.7‐Mb deletion documented a mixture of cells with the 13q‐ chromosome and those with 46,XX chromosomes, the latter of which are likely to have been derived from contaminating decidual cells. This left the 1.4‐Mb 3p deletion as the only instance with submicroscopic imbalance detected, giving a frequency of 1 in 19 (5%) G‐banding normal abortions. © 2006 Wiley‐Liss, Inc.</description><subject>Abortion, Spontaneous - genetics</subject><subject>array CGH</subject><subject>Biological and medical sciences</subject><subject>chromosomal aberrations</subject><subject>Chromosome Aberrations</subject><subject>Chromosome Deletion</subject><subject>Chromosomes, Artificial, Bacterial - genetics</subject><subject>Chromosomes, Human, Pair 13 - genetics</subject><subject>Chromosomes, Human, Pair 3 - genetics</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Karyotyping</subject><subject>Medical sciences</subject><subject>microarray comparative genomic hybridization</subject><subject>Nucleic Acid Hybridization</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, First - genetics</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>spontaneous abortion</subject><issn>1552-4825</issn><issn>1552-4833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1v1DAQxa2qqC2lN87IF-iFLP6IY_u4FNhSFRBSqx6tieO0bpM42FlK-OvJkqW90dNYo9-bN56H0EtKFpQQ9g5u2-sFLDjNGd1BB1QIluWK892HNxP76HlKt4RwImSxh_ZpoUkhBDlAcRkjjNiGtocIg__p8LXrQustvhnL6Cv_e-qGDkMHzZh8wr7DtY9pyIboW5cGF3HqQzdA58I6YShD3AgSvvfDDT7uQmyhOcZ3EMcwjL1LL9CzGprkjrb1EF1--nhxcpqdf1t9PlmeZzbnjGbaKkIhF0RRWfKKO8lpIWypqZZW0MrmNRSVFFyWjtqC1VoT0FqrSrFSaOCH6M08t4_hx3ra1LQ-Wdc086amUFIxSfMnQUY0J5KLCXw7gzaGlKKrTT_dYPqYocRswjCbMAyYv2FM-Kvt3HXZuuoR3l5_Al5vAUgWmjpCZ3165BTRWqiNL5-5e9-48b-mZnn2ZfXPPptVfgrp14MK4p0pJJfCXH1dGf3-w5n8fkqM4H8A9Tuztg</recordid><startdate>20060915</startdate><enddate>20060915</enddate><creator>Shimokawa, Osamu</creator><creator>Harada, Naoki</creator><creator>Miyake, Noriko</creator><creator>Satoh, Kanako</creator><creator>Mizuguchi, Takeshi</creator><creator>Niikawa, Norio</creator><creator>Matsumoto, Naomichi</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20060915</creationdate><title>Array comparative genomic hybridization analysis in first-trimester spontaneous abortions with 'normal' karyotypes</title><author>Shimokawa, Osamu ; Harada, Naoki ; Miyake, Noriko ; Satoh, Kanako ; Mizuguchi, Takeshi ; Niikawa, Norio ; Matsumoto, Naomichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4321-9c801a450817b3d3e73165cb9197c51dc4fa6d7537be1c62f990a9998d82b59a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Abortion, Spontaneous - genetics</topic><topic>array CGH</topic><topic>Biological and medical sciences</topic><topic>chromosomal aberrations</topic><topic>Chromosome Aberrations</topic><topic>Chromosome Deletion</topic><topic>Chromosomes, Artificial, Bacterial - genetics</topic><topic>Chromosomes, Human, Pair 13 - genetics</topic><topic>Chromosomes, Human, Pair 3 - genetics</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Karyotyping</topic><topic>Medical sciences</topic><topic>microarray comparative genomic hybridization</topic><topic>Nucleic Acid Hybridization</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, First - genetics</topic><topic>Pregnancy. Fetus. 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Part A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shimokawa, Osamu</au><au>Harada, Naoki</au><au>Miyake, Noriko</au><au>Satoh, Kanako</au><au>Mizuguchi, Takeshi</au><au>Niikawa, Norio</au><au>Matsumoto, Naomichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Array comparative genomic hybridization analysis in first-trimester spontaneous abortions with 'normal' karyotypes</atitle><jtitle>American journal of medical genetics. Part A</jtitle><addtitle>Am. J. Med. Genet</addtitle><date>2006-09-15</date><risdate>2006</risdate><volume>140A</volume><issue>18</issue><spage>1931</spage><epage>1935</epage><pages>1931-1935</pages><issn>1552-4825</issn><eissn>1552-4833</eissn><abstract>Array comparative genomic hybridization (array CGH) analysis was conducted in chorionic villous samples from 20 first‐trimester spontaneous abortions with G‐banding normal chromosomes. A microarray, containing 2,173 BAC clones and covering the whole genome with a 1.5‐Mb resolution, was constructed and used in the analysis. Two deletions were identified: a 1.4‐Mb deletion at 3p26.2‐p26.3 and a 13.7‐Mb deletion at 13q32.3‐qter. Reexamination of chromosome preparations from the sample with the 13.7‐Mb deletion documented a mixture of cells with the 13q‐ chromosome and those with 46,XX chromosomes, the latter of which are likely to have been derived from contaminating decidual cells. This left the 1.4‐Mb 3p deletion as the only instance with submicroscopic imbalance detected, giving a frequency of 1 in 19 (5%) G‐banding normal abortions. © 2006 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>16906550</pmid><doi>10.1002/ajmg.a.31421</doi><tpages>5</tpages></addata></record> |
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| ispartof | American journal of medical genetics. Part A, 2006-09, Vol.140A (18), p.1931-1935 |
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| subjects | Abortion, Spontaneous - genetics array CGH Biological and medical sciences chromosomal aberrations Chromosome Aberrations Chromosome Deletion Chromosomes, Artificial, Bacterial - genetics Chromosomes, Human, Pair 13 - genetics Chromosomes, Human, Pair 3 - genetics Diseases of mother, fetus and pregnancy Female Gynecology. Andrology. Obstetrics Humans Karyotyping Medical sciences microarray comparative genomic hybridization Nucleic Acid Hybridization Oligonucleotide Array Sequence Analysis Pregnancy Pregnancy Trimester, First - genetics Pregnancy. Fetus. Placenta spontaneous abortion |
| title | Array comparative genomic hybridization analysis in first-trimester spontaneous abortions with 'normal' karyotypes |
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