The Unfolded Protein Response in Lens Epithelial Cells from Galactosemic Rat Lenses

Diabetic complications are associated with hypoglycemia and hyperglycemia. The purpose of this study was to investigate the effect of both glucose deprivation and hyperglycemia on the induction of endoplasmic reticulum (ER) stress and the subsequent activation of the unfolded protein response (UPR)...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2006-09, Vol.47 (9), p.3951-3959
Hauptverfasser:	Mulhern, Michael L, Madson, Christian J, Danford, Andrew, Ikesugi, Kengo, Kador, Peter F, Shinohara, Toshimichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 4 - metabolism Animals Apoptosis Biological and medical sciences Caspases - metabolism Cataract - metabolism Cataract - pathology Cells, Cultured Crystallins - metabolism Endoplasmic Reticulum - metabolism Endoplasmic Reticulum - pathology Epithelial Cells - metabolism Epithelial Cells - pathology Eye and associated structures. Visual pathways and centers. Vision Female Fundamental and applied biological sciences. Psychology Galactose - administration & dosage Galactosemias - metabolism Galactosemias - pathology Glutathione - metabolism Heat-Shock Proteins - metabolism Hyperglycemia - metabolism Hyperglycemia - pathology Hypoglycemia - metabolism Hypoglycemia - pathology Immunoblotting In Situ Nick-End Labeling Lens, Crystalline - metabolism Lens, Crystalline - pathology Molecular Chaperones - metabolism Oxidative Stress Protein Denaturation Rats Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Transcription Factor CHOP - metabolism Vertebrates: nervous system and sense organs
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