The invasion of the midgut of the mosquito Culex ( Culex) quinquefasciatus Say, 1823 by the helminth Litomosoides chagasfilhoi Moraes Neto, Lanfredi and De Souza, 1997
The Litomosoides chagasfilhoi helminth was studied as a model for microfilaria invasion of the midgut of Culex quinquefasciatus mosquito, vector of Wuchereria bancrofti helminth, causative agent of the human filariasis. Histology and transmission and scanning electron microscopy were utilized to sho...
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| Veröffentlicht in: | Journal of invertebrate pathology 2006-09, Vol.93 (1), p.1-10 |
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| creator | Santos, J.N. Lanfredi, R.M. Pimenta, P.F.P. |
| description | The
Litomosoides chagasfilhoi helminth was studied as a model for microfilaria invasion of the midgut of
Culex quinquefasciatus mosquito, vector of
Wuchereria bancrofti helminth, causative agent of the human filariasis. Histology and transmission and scanning electron microscopy were utilized to show the topography of mosquito midgut invasion by the helminth. An analysis of midguts dissected at different time points after a blood meal demonstrated that the microfilariae interacted and crossed the peritrophic matrix and the midgut epithelium of
C. quinquefasciatus. The microfilariae invaded preferentially the mosquito abdominal midgut and the invasion process occurred between 2 and 3
h after the blood feeding. In some cases, microfilariae caused an opening in the midgut that separated the epithelial cells, while in others cases, the worms caused the detachment of cells from the epithelium. Ultimately,
L. chagasfilhoi crossing activity appeared to damage the midgut. It was also observed that the microfilariae lost their sheaths during their passage through the fibrous material of the peritrophic matrix, before they reached the midgut epithelium. Since the exsheathment process is necessary for the continuity of larvae development, it seems that the passage through the peritrophic matrix is an important step for the parasite’s life cycle. This experimental model revealed details of the interaction process of helminthes within the vector midgut, contributing to the knowledge of factors involved in the vector competence of
C. quinquefasciatus as a vector of filariasis. |
| doi_str_mv | 10.1016/j.jip.2006.05.002 |
| format | Article |
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Litomosoides chagasfilhoi helminth was studied as a model for microfilaria invasion of the midgut of
Culex quinquefasciatus mosquito, vector of
Wuchereria bancrofti helminth, causative agent of the human filariasis. Histology and transmission and scanning electron microscopy were utilized to show the topography of mosquito midgut invasion by the helminth. An analysis of midguts dissected at different time points after a blood meal demonstrated that the microfilariae interacted and crossed the peritrophic matrix and the midgut epithelium of
C. quinquefasciatus. The microfilariae invaded preferentially the mosquito abdominal midgut and the invasion process occurred between 2 and 3
h after the blood feeding. In some cases, microfilariae caused an opening in the midgut that separated the epithelial cells, while in others cases, the worms caused the detachment of cells from the epithelium. Ultimately,
L. chagasfilhoi crossing activity appeared to damage the midgut. It was also observed that the microfilariae lost their sheaths during their passage through the fibrous material of the peritrophic matrix, before they reached the midgut epithelium. Since the exsheathment process is necessary for the continuity of larvae development, it seems that the passage through the peritrophic matrix is an important step for the parasite’s life cycle. This experimental model revealed details of the interaction process of helminthes within the vector midgut, contributing to the knowledge of factors involved in the vector competence of
C. quinquefasciatus as a vector of filariasis.</description><identifier>ISSN: 0022-2011</identifier><identifier>EISSN: 1096-0805</identifier><identifier>DOI: 10.1016/j.jip.2006.05.002</identifier><identifier>PMID: 16780868</identifier><identifier>CODEN: JIVPAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; cell invasion ; Culex - parasitology ; Culex - ultrastructure ; Culex quinquefasciatus ; disease models ; epithelial cells ; Exsheathment ; filariasis ; Filariasis - parasitology ; Filarioidea - pathogenicity ; Filarioidea - physiology ; Filarioidea - ultrastructure ; Fundamental and applied biological sciences. Psychology ; Host-Parasite Interactions ; infection ; insect vectors ; Insect Vectors - parasitology ; Litomosoides ; Litosomoides chagasfilhoi ; Medically important nuisances and vectors, pests of stored products and materials: population survey and control ; Microfilariae ; Microfilariae - pathogenicity ; Microfilariae - physiology ; Microfilariae - ultrastructure ; Microscopy, Electron, Scanning ; midgut ; midgut epithelium ; Midgut invasion ; nematode exsheathment ; nematode infections ; Parasitic Diseases, Animal - parasitology ; Peritrophic matrix ; peritrophic membrane ; vector competence ; Vector interaction ; Vectors. Intermediate hosts ; Virulence - physiology</subject><ispartof>Journal of invertebrate pathology, 2006-09, Vol.93 (1), p.1-10</ispartof><rights>2006 Elsevier Inc.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jip.2006.05.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18100496$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16780868$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Santos, J.N.</creatorcontrib><creatorcontrib>Lanfredi, R.M.</creatorcontrib><creatorcontrib>Pimenta, P.F.P.</creatorcontrib><title>The invasion of the midgut of the mosquito Culex ( Culex) quinquefasciatus Say, 1823 by the helminth Litomosoides chagasfilhoi Moraes Neto, Lanfredi and De Souza, 1997</title><title>Journal of invertebrate pathology</title><addtitle>J Invertebr Pathol</addtitle><description>The
Litomosoides chagasfilhoi helminth was studied as a model for microfilaria invasion of the midgut of
Culex quinquefasciatus mosquito, vector of
Wuchereria bancrofti helminth, causative agent of the human filariasis. Histology and transmission and scanning electron microscopy were utilized to show the topography of mosquito midgut invasion by the helminth. An analysis of midguts dissected at different time points after a blood meal demonstrated that the microfilariae interacted and crossed the peritrophic matrix and the midgut epithelium of
C. quinquefasciatus. The microfilariae invaded preferentially the mosquito abdominal midgut and the invasion process occurred between 2 and 3
h after the blood feeding. In some cases, microfilariae caused an opening in the midgut that separated the epithelial cells, while in others cases, the worms caused the detachment of cells from the epithelium. Ultimately,
L. chagasfilhoi crossing activity appeared to damage the midgut. It was also observed that the microfilariae lost their sheaths during their passage through the fibrous material of the peritrophic matrix, before they reached the midgut epithelium. Since the exsheathment process is necessary for the continuity of larvae development, it seems that the passage through the peritrophic matrix is an important step for the parasite’s life cycle. This experimental model revealed details of the interaction process of helminthes within the vector midgut, contributing to the knowledge of factors involved in the vector competence of
C. quinquefasciatus as a vector of filariasis.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>cell invasion</subject><subject>Culex - parasitology</subject><subject>Culex - ultrastructure</subject><subject>Culex quinquefasciatus</subject><subject>disease models</subject><subject>epithelial cells</subject><subject>Exsheathment</subject><subject>filariasis</subject><subject>Filariasis - parasitology</subject><subject>Filarioidea - pathogenicity</subject><subject>Filarioidea - physiology</subject><subject>Filarioidea - ultrastructure</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Host-Parasite Interactions</subject><subject>infection</subject><subject>insect vectors</subject><subject>Insect Vectors - parasitology</subject><subject>Litomosoides</subject><subject>Litosomoides chagasfilhoi</subject><subject>Medically important nuisances and vectors, pests of stored products and materials: population survey and control</subject><subject>Microfilariae</subject><subject>Microfilariae - pathogenicity</subject><subject>Microfilariae - physiology</subject><subject>Microfilariae - ultrastructure</subject><subject>Microscopy, Electron, Scanning</subject><subject>midgut</subject><subject>midgut epithelium</subject><subject>Midgut invasion</subject><subject>nematode exsheathment</subject><subject>nematode infections</subject><subject>Parasitic Diseases, Animal - parasitology</subject><subject>Peritrophic matrix</subject><subject>peritrophic membrane</subject><subject>vector competence</subject><subject>Vector interaction</subject><subject>Vectors. Intermediate hosts</subject><subject>Virulence - physiology</subject><issn>0022-2011</issn><issn>1096-0805</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkt2O0zAQhS0EYrsLD8AN-AYE0iaM8-M44gqVX6nARXevrYljN67SuBsnqy0vxGsySwtcjT36zkhz5jD2TEAqQMi323Tr92kGIFMoU4DsAVsIqGUCCsqHbEGdLMlAiDN2HuMW6FXK-jE7E7JSoKRasF9XneV-uMXow8CD4xP9d77dzNO_X4g3s58CX869veOvj_UNp-ZwM1uH0Xic5sjXeLjkQmU5bw5_lJ3td36YOr4iOY0JvrWRmw43GJ3vu-D5tzAi9b7bKVzyFQ5utK3nOLT8g-XrMP9EGlnX1RP2yGEf7dNTvWDXnz5eLb8kqx-fvy7frxKbi3JKpM2bIne5rBvMM0QyIrfCZiarZFsa55QwCkRjqqpo26YsJMlEgdJhVSkSXrBXx7n7MdBycdI7H43texxsmKOWqlKZqAWBz0_g3Oxsq_ej3-F40H-tJeDlCSCDsHcjDsbH_5wSAEUtiXtx5BwGjZuRmOs1HS2nawFAVRPx7khYWvzW21GT43Yw5NRozaTb4LUAfR8JvdUUCX0fCQ2lpgDkvwFz46XA</recordid><startdate>20060901</startdate><enddate>20060901</enddate><creator>Santos, J.N.</creator><creator>Lanfredi, R.M.</creator><creator>Pimenta, P.F.P.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20060901</creationdate><title>The invasion of the midgut of the mosquito Culex ( Culex) quinquefasciatus Say, 1823 by the helminth Litomosoides chagasfilhoi Moraes Neto, Lanfredi and De Souza, 1997</title><author>Santos, J.N. ; Lanfredi, R.M. ; Pimenta, P.F.P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e315t-6e3b43f369ba32aa0803e1e2c276d5cff81c801bc774ddb54631514a6fa7783f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>cell invasion</topic><topic>Culex - parasitology</topic><topic>Culex - ultrastructure</topic><topic>Culex quinquefasciatus</topic><topic>disease models</topic><topic>epithelial cells</topic><topic>Exsheathment</topic><topic>filariasis</topic><topic>Filariasis - parasitology</topic><topic>Filarioidea - pathogenicity</topic><topic>Filarioidea - physiology</topic><topic>Filarioidea - ultrastructure</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Host-Parasite Interactions</topic><topic>infection</topic><topic>insect vectors</topic><topic>Insect Vectors - parasitology</topic><topic>Litomosoides</topic><topic>Litosomoides chagasfilhoi</topic><topic>Medically important nuisances and vectors, pests of stored products and materials: population survey and control</topic><topic>Microfilariae</topic><topic>Microfilariae - pathogenicity</topic><topic>Microfilariae - physiology</topic><topic>Microfilariae - ultrastructure</topic><topic>Microscopy, Electron, Scanning</topic><topic>midgut</topic><topic>midgut epithelium</topic><topic>Midgut invasion</topic><topic>nematode exsheathment</topic><topic>nematode infections</topic><topic>Parasitic Diseases, Animal - parasitology</topic><topic>Peritrophic matrix</topic><topic>peritrophic membrane</topic><topic>vector competence</topic><topic>Vector interaction</topic><topic>Vectors. Intermediate hosts</topic><topic>Virulence - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Santos, J.N.</creatorcontrib><creatorcontrib>Lanfredi, R.M.</creatorcontrib><creatorcontrib>Pimenta, P.F.P.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of invertebrate pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Santos, J.N.</au><au>Lanfredi, R.M.</au><au>Pimenta, P.F.P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The invasion of the midgut of the mosquito Culex ( Culex) quinquefasciatus Say, 1823 by the helminth Litomosoides chagasfilhoi Moraes Neto, Lanfredi and De Souza, 1997</atitle><jtitle>Journal of invertebrate pathology</jtitle><addtitle>J Invertebr Pathol</addtitle><date>2006-09-01</date><risdate>2006</risdate><volume>93</volume><issue>1</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>0022-2011</issn><eissn>1096-0805</eissn><coden>JIVPAZ</coden><abstract>The
Litomosoides chagasfilhoi helminth was studied as a model for microfilaria invasion of the midgut of
Culex quinquefasciatus mosquito, vector of
Wuchereria bancrofti helminth, causative agent of the human filariasis. Histology and transmission and scanning electron microscopy were utilized to show the topography of mosquito midgut invasion by the helminth. An analysis of midguts dissected at different time points after a blood meal demonstrated that the microfilariae interacted and crossed the peritrophic matrix and the midgut epithelium of
C. quinquefasciatus. The microfilariae invaded preferentially the mosquito abdominal midgut and the invasion process occurred between 2 and 3
h after the blood feeding. In some cases, microfilariae caused an opening in the midgut that separated the epithelial cells, while in others cases, the worms caused the detachment of cells from the epithelium. Ultimately,
L. chagasfilhoi crossing activity appeared to damage the midgut. It was also observed that the microfilariae lost their sheaths during their passage through the fibrous material of the peritrophic matrix, before they reached the midgut epithelium. Since the exsheathment process is necessary for the continuity of larvae development, it seems that the passage through the peritrophic matrix is an important step for the parasite’s life cycle. This experimental model revealed details of the interaction process of helminthes within the vector midgut, contributing to the knowledge of factors involved in the vector competence of
C. quinquefasciatus as a vector of filariasis.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>16780868</pmid><doi>10.1016/j.jip.2006.05.002</doi><tpages>10</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences cell invasion Culex - parasitology Culex - ultrastructure Culex quinquefasciatus disease models epithelial cells Exsheathment filariasis Filariasis - parasitology Filarioidea - pathogenicity Filarioidea - physiology Filarioidea - ultrastructure Fundamental and applied biological sciences. Psychology Host-Parasite Interactions infection insect vectors Insect Vectors - parasitology Litomosoides Litosomoides chagasfilhoi Medically important nuisances and vectors, pests of stored products and materials: population survey and control Microfilariae Microfilariae - pathogenicity Microfilariae - physiology Microfilariae - ultrastructure Microscopy, Electron, Scanning midgut midgut epithelium Midgut invasion nematode exsheathment nematode infections Parasitic Diseases, Animal - parasitology Peritrophic matrix peritrophic membrane vector competence Vector interaction Vectors. Intermediate hosts Virulence - physiology |
| title | The invasion of the midgut of the mosquito Culex ( Culex) quinquefasciatus Say, 1823 by the helminth Litomosoides chagasfilhoi Moraes Neto, Lanfredi and De Souza, 1997 |
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