Improvement of walking disturbance by beraprost sodium in rat femoral artery occlusion models
In rats receiving bilateral femoral arteries ligation (day 0), repeated oral administration of the prostacyclin derivative beraprost sodium (50 μg/kg, b.i.d.) from day 1 to day 5 resulted in a significant prolongation in walking time in rotarod walking exercise performed on day 5. Similarly, results...
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| Veröffentlicht in: | European journal of pharmacology 2006-09, Vol.545 (2), p.173-176 |
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| container_title | European journal of pharmacology |
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| creator | Miyamoto, Mitsuko Tayama, Toshikazu Yamaguchi, Sin'ichi Kaneko, Masayuki Kurumatani, Hajimu |
| description | In rats receiving bilateral femoral arteries ligation (day 0), repeated oral administration of the prostacyclin derivative beraprost sodium (50 μg/kg, b.i.d.) from day 1 to day 5 resulted in a significant prolongation in walking time in rotarod walking exercise performed on day 5. Similarly, results were obtained in rats with bilateral femoral arterial thrombosis induced by application of FeCl
3/HCl. In the ligation model, a significant increase was observed in femoral/carotid arterial blood pressure ratio even on day 2. These results indicated that beraprost sodium improves blood flow and walking disturbances associated with arterial occlusion in rats. |
| doi_str_mv | 10.1016/j.ejphar.2006.06.050 |
| format | Article |
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3/HCl. In the ligation model, a significant increase was observed in femoral/carotid arterial blood pressure ratio even on day 2. These results indicated that beraprost sodium improves blood flow and walking disturbances associated with arterial occlusion in rats.</description><subject>Animals</subject><subject>Arterial Occlusive Diseases - drug therapy</subject><subject>Beraprost sodium</subject><subject>Biological and medical sciences</subject><subject>Epoprostenol - analogs & derivatives</subject><subject>Epoprostenol - therapeutic use</subject><subject>Femoral Artery</subject><subject>Intermittent claudication</subject><subject>Intermittent Claudication - drug therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Regional Blood Flow - drug effects</topic><topic>Walking</topic><topic>Walking disturbance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miyamoto, Mitsuko</creatorcontrib><creatorcontrib>Tayama, Toshikazu</creatorcontrib><creatorcontrib>Yamaguchi, Sin'ichi</creatorcontrib><creatorcontrib>Kaneko, Masayuki</creatorcontrib><creatorcontrib>Kurumatani, Hajimu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miyamoto, Mitsuko</au><au>Tayama, Toshikazu</au><au>Yamaguchi, Sin'ichi</au><au>Kaneko, Masayuki</au><au>Kurumatani, Hajimu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improvement of walking disturbance by beraprost sodium in rat femoral artery occlusion models</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2006-09-18</date><risdate>2006</risdate><volume>545</volume><issue>2</issue><spage>173</spage><epage>176</epage><pages>173-176</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>In rats receiving bilateral femoral arteries ligation (day 0), repeated oral administration of the prostacyclin derivative beraprost sodium (50 μg/kg, b.i.d.) from day 1 to day 5 resulted in a significant prolongation in walking time in rotarod walking exercise performed on day 5. 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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Arterial Occlusive Diseases - drug therapy Beraprost sodium Biological and medical sciences Epoprostenol - analogs & derivatives Epoprostenol - therapeutic use Femoral Artery Intermittent claudication Intermittent Claudication - drug therapy Male Medical sciences Pharmacology. Drug treatments Rats Rats, Wistar Regional Blood Flow - drug effects Walking Walking disturbance |
| title | Improvement of walking disturbance by beraprost sodium in rat femoral artery occlusion models |
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