Relation of Erythropoietin and Erythropoietin Receptor Expression to Hypoxia and Anemia in Head and Neck Squamous Cell Carcinoma

Purpose: The use of erythropoietin in head and neck squamous cell carcinoma (HNSCC) has been associated with poor survival. This study examines the protein and mRNA expression of erythropoietin and erythropoietin receptor in HNSCC and their relation to hypoxia, hemoglobin (Hb), and clinical outcome....

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Veröffentlicht in:	Clinical cancer research 2005-11, Vol.11 (21), p.7614-7620
Hauptverfasser:	WINTER, Stuart C, SHAH, Ketan A, CAMPO, Leticia, TURLEY, Helen, LEEK, Russell, CORBRIDGE, Rogan J, COX, Graham J, HARRIS, Adrian L
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia Anemias. Hemoglobinopathies Antigens, Neoplasm - biosynthesis Antineoplastic agents Biological and medical sciences Carbonic Anhydrase IX Carbonic Anhydrases - biosynthesis Carcinoma, Squamous Cell - metabolism Cytoplasm - metabolism Disease-Free Survival Diseases of red blood cells DNA, Complementary - metabolism Erythropoietin Erythropoietin - biosynthesis Erythropoietin receptor Female Follow-Up Studies Gene Expression Regulation, Neoplastic Head and Neck Neoplasms - metabolism Hematologic and hematopoietic diseases Hemoglobins - metabolism HNSCC Humans Hypoxia Immunohistochemistry Male Medical sciences Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Pharmacology. Drug treatments Protein Array Analysis Receptors, Erythropoietin - biosynthesis Reverse Transcriptase Polymerase Chain Reaction RNA - chemistry RNA - metabolism RNA, Messenger - metabolism Transcription, Genetic Treatment Outcome Tumors
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