Elevated Glucose Changes the Expression of Ionotropic Glutamate Receptor Subunits and Impairs Calcium Homeostasis in Retinal Neural Cells

Altered glutamatergic neurotransmission and calcium homeostasis may contribute to retinal neural cell dysfunction and apoptosis in diabetic retinopathy (DR). The purpose of this study was to determine the effect of high glucose on the protein content of alpha-amino-3-hydroxy-5-methylisoxazole-4-prop...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2006-09, Vol.47 (9), p.4130-4137
Hauptverfasser:	Santiago, Ana R, Rosa, Susana C, Santos, Paulo F, Cristovao, Armando J, Barber, Alistair J, Ambrosio, Antonio F
Format:	Artikel
Sprache:	eng
Schlagworte:	Aniline Compounds - metabolism Animals Animals, Newborn Biological and medical sciences Blotting, Western Calcium - metabolism Cells, Cultured Eye and associated structures. Visual pathways and centers. Vision Fluorescent Antibody Technique, Indirect Fundamental and applied biological sciences. Psychology Glucose - pharmacology Homeostasis - drug effects Microscopy, Confocal Neurons - drug effects Neurons - metabolism Protein Subunits - metabolism Rats Rats, Sprague-Dawley Receptors, AMPA - metabolism Receptors, Kainic Acid - metabolism Retina - cytology Retina - drug effects Retina - metabolism Vertebrates: nervous system and sense organs Xanthenes - metabolism
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