Surgical Ventricular Restoration for Advanced Congestive Heart Failure: Should Pulmonary Hypertension Be a Contraindication?
Surgical ventricular restoration (SVR) is an established therapy for congestive heart failure due to ischemic cardiomyopathy. Pulmonary hypertension (PHTN) has been considered a contraindication for SVR owing to a presumed increase in operative risk. However, outcomes in these patients and the impac...
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| Veröffentlicht in: | The Annals of thoracic surgery 2006-09, Vol.82 (3), p.879-888 |
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| creator | Patel, Nishant D. Williams, Jason A. Nwakanma, Lois U. Waldron, Michele M. Bluemke, David A. Conte, John V. |
| description | Surgical ventricular restoration (SVR) is an established therapy for congestive heart failure due to ischemic cardiomyopathy. Pulmonary hypertension (PHTN) has been considered a contraindication for SVR owing to a presumed increase in operative risk. However, outcomes in these patients and the impact of SVR on PHTN have not been specifically evaluated.
We retrospectively reviewed SVR patients between January 2002 and June 2005. Patients were classified as PHTN (mean pulmonary artery pressure ≥ 25 mm Hg) and no PHTN (mPAP < 25 mm Hg) based on preoperative cardiac catheterization. Cardiac function was assessed using magnetic resonance imaging and echocardiography. Follow-up was 100%.
Sixty-nine patients underwent SVR for congestive heart failure. Thirty-six percent (25 of 69) had preoperative PHTN. Preoperatively, PHTN patients had significantly lower ejection fraction (21.1% versus 30.0%;
p = 0.005) and larger left ventricular end-systolic volume index (119.0 versus 88.7 mL/m
2;
p = 0.04) than patients without PHTN. All PHTN patients and 95.5% (42 of 44) of the no PHTN group were New York Heart Association (NYHA) class III/IV preoperatively. There was 1 operative death in the PHTN group. Surgical ventricular restoration significantly improved cardiac function and pulmonary pressures for PHTN patients. Both groups had similar cardiac function postoperatively. Seventy-two percent (18 of 25) of PHTN patients and 69.0% (29 of 42) of patients without PHTN improved to NYHA class I/II at follow-up. Kaplan-Meier survival of PHTN patients was 68.1% at 3 years, which was lower than patients without PHTN (81.4%;
p = 0.44), but not statistically significant. Kaplan-Meier 3-year survival for all SVR patients was 76.6%.
Surgical ventricular restoration is a good treatment option in patients with advanced congestive heart failure and PHTN. Our early results are promising and should prompt further studies to confirm these findings. |
| doi_str_mv | 10.1016/j.athoracsur.2006.04.016 |
| format | Article |
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We retrospectively reviewed SVR patients between January 2002 and June 2005. Patients were classified as PHTN (mean pulmonary artery pressure ≥ 25 mm Hg) and no PHTN (mPAP < 25 mm Hg) based on preoperative cardiac catheterization. Cardiac function was assessed using magnetic resonance imaging and echocardiography. Follow-up was 100%.
Sixty-nine patients underwent SVR for congestive heart failure. Thirty-six percent (25 of 69) had preoperative PHTN. Preoperatively, PHTN patients had significantly lower ejection fraction (21.1% versus 30.0%;
p = 0.005) and larger left ventricular end-systolic volume index (119.0 versus 88.7 mL/m
2;
p = 0.04) than patients without PHTN. All PHTN patients and 95.5% (42 of 44) of the no PHTN group were New York Heart Association (NYHA) class III/IV preoperatively. There was 1 operative death in the PHTN group. Surgical ventricular restoration significantly improved cardiac function and pulmonary pressures for PHTN patients. Both groups had similar cardiac function postoperatively. Seventy-two percent (18 of 25) of PHTN patients and 69.0% (29 of 42) of patients without PHTN improved to NYHA class I/II at follow-up. Kaplan-Meier survival of PHTN patients was 68.1% at 3 years, which was lower than patients without PHTN (81.4%;
p = 0.44), but not statistically significant. Kaplan-Meier 3-year survival for all SVR patients was 76.6%.
Surgical ventricular restoration is a good treatment option in patients with advanced congestive heart failure and PHTN. Our early results are promising and should prompt further studies to confirm these findings.</description><identifier>ISSN: 0003-4975</identifier><identifier>EISSN: 1552-6259</identifier><identifier>DOI: 10.1016/j.athoracsur.2006.04.016</identifier><identifier>PMID: 16928501</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Aged ; Cardiac Surgical Procedures ; Comorbidity ; Contraindications ; Coronary Artery Bypass - statistics & numerical data ; Female ; Heart Failure - complications ; Heart Failure - surgery ; Heart Ventricles - surgery ; Humans ; Hypertension, Pulmonary - complications ; Length of Stay - statistics & numerical data ; Male ; Middle Aged ; Mitral Valve Insufficiency - complications ; Mitral Valve Insufficiency - surgery ; Postoperative Complications - epidemiology ; Proportional Hazards Models ; Retrospective Studies ; Risk ; Stroke Volume ; Treatment Outcome</subject><ispartof>The Annals of thoracic surgery, 2006-09, Vol.82 (3), p.879-888</ispartof><rights>2006 The Society of Thoracic Surgeons</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-465a0ff87ba6876c2da06cfbfa75da21d4a7be38700a95158537eaa9d20d21b83</citedby><cites>FETCH-LOGICAL-c407t-465a0ff87ba6876c2da06cfbfa75da21d4a7be38700a95158537eaa9d20d21b83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16928501$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Patel, Nishant D.</creatorcontrib><creatorcontrib>Williams, Jason A.</creatorcontrib><creatorcontrib>Nwakanma, Lois U.</creatorcontrib><creatorcontrib>Waldron, Michele M.</creatorcontrib><creatorcontrib>Bluemke, David A.</creatorcontrib><creatorcontrib>Conte, John V.</creatorcontrib><title>Surgical Ventricular Restoration for Advanced Congestive Heart Failure: Should Pulmonary Hypertension Be a Contraindication?</title><title>The Annals of thoracic surgery</title><addtitle>Ann Thorac Surg</addtitle><description>Surgical ventricular restoration (SVR) is an established therapy for congestive heart failure due to ischemic cardiomyopathy. Pulmonary hypertension (PHTN) has been considered a contraindication for SVR owing to a presumed increase in operative risk. However, outcomes in these patients and the impact of SVR on PHTN have not been specifically evaluated.
We retrospectively reviewed SVR patients between January 2002 and June 2005. Patients were classified as PHTN (mean pulmonary artery pressure ≥ 25 mm Hg) and no PHTN (mPAP < 25 mm Hg) based on preoperative cardiac catheterization. Cardiac function was assessed using magnetic resonance imaging and echocardiography. Follow-up was 100%.
Sixty-nine patients underwent SVR for congestive heart failure. Thirty-six percent (25 of 69) had preoperative PHTN. Preoperatively, PHTN patients had significantly lower ejection fraction (21.1% versus 30.0%;
p = 0.005) and larger left ventricular end-systolic volume index (119.0 versus 88.7 mL/m
2;
p = 0.04) than patients without PHTN. All PHTN patients and 95.5% (42 of 44) of the no PHTN group were New York Heart Association (NYHA) class III/IV preoperatively. There was 1 operative death in the PHTN group. Surgical ventricular restoration significantly improved cardiac function and pulmonary pressures for PHTN patients. Both groups had similar cardiac function postoperatively. Seventy-two percent (18 of 25) of PHTN patients and 69.0% (29 of 42) of patients without PHTN improved to NYHA class I/II at follow-up. Kaplan-Meier survival of PHTN patients was 68.1% at 3 years, which was lower than patients without PHTN (81.4%;
p = 0.44), but not statistically significant. Kaplan-Meier 3-year survival for all SVR patients was 76.6%.
Surgical ventricular restoration is a good treatment option in patients with advanced congestive heart failure and PHTN. Our early results are promising and should prompt further studies to confirm these findings.</description><subject>Aged</subject><subject>Cardiac Surgical Procedures</subject><subject>Comorbidity</subject><subject>Contraindications</subject><subject>Coronary Artery Bypass - statistics & numerical data</subject><subject>Female</subject><subject>Heart Failure - complications</subject><subject>Heart Failure - surgery</subject><subject>Heart Ventricles - surgery</subject><subject>Humans</subject><subject>Hypertension, Pulmonary - complications</subject><subject>Length of Stay - statistics & numerical data</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mitral Valve Insufficiency - complications</subject><subject>Mitral Valve Insufficiency - surgery</subject><subject>Postoperative Complications - epidemiology</subject><subject>Proportional Hazards Models</subject><subject>Retrospective Studies</subject><subject>Risk</subject><subject>Stroke Volume</subject><subject>Treatment Outcome</subject><issn>0003-4975</issn><issn>1552-6259</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUE1v1DAQtRCILoW_gHziljD2xonDBbWrlkWqBKLA1ZrYk9arbLzYyUqV-PE42pV65DQava-ZxxgXUAoQ9cddidNjiGjTHEsJUJdQlRl4wVZCKVnUUrUv2QoA1kXVNuqCvUlpl1eZ4dfsQtSt1ArEiv29n-ODtzjw3zRO0dt5wMh_UJqy_eTDyPsQ-ZU74mjJ8U0YHzLmj8S3hHHit-iHOdInfv8Y5sHx7_OwDyPGJ759OlCcaEyLyTVxXMRTRD-6nLdYf37LXvU4JHp3npfs1-3Nz822uPv25evm6q6wFTRTUdUKoe9102Gtm9pKh1DbvuuxUQ6lcBU2Ha11A4CtEkqrdUOIrZPgpOj0-pJ9OPkeYvgz5_vN3idLw4AjhTmZ7KpBt5CJ-kS0MaQUqTeH6Pf5GyPALM2bnXlu3izNG6hMBrL0_Tlj7vbknoXnqjPh-kSg_OnRUzTJelpa9ZHsZFzw_0_5B_svnQ4</recordid><startdate>20060901</startdate><enddate>20060901</enddate><creator>Patel, Nishant D.</creator><creator>Williams, Jason A.</creator><creator>Nwakanma, Lois U.</creator><creator>Waldron, Michele M.</creator><creator>Bluemke, David A.</creator><creator>Conte, John V.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060901</creationdate><title>Surgical Ventricular Restoration for Advanced Congestive Heart Failure: Should Pulmonary Hypertension Be a Contraindication?</title><author>Patel, Nishant D. ; Williams, Jason A. ; Nwakanma, Lois U. ; Waldron, Michele M. ; Bluemke, David A. ; Conte, John V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-465a0ff87ba6876c2da06cfbfa75da21d4a7be38700a95158537eaa9d20d21b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aged</topic><topic>Cardiac Surgical Procedures</topic><topic>Comorbidity</topic><topic>Contraindications</topic><topic>Coronary Artery Bypass - statistics & numerical data</topic><topic>Female</topic><topic>Heart Failure - complications</topic><topic>Heart Failure - surgery</topic><topic>Heart Ventricles - surgery</topic><topic>Humans</topic><topic>Hypertension, Pulmonary - complications</topic><topic>Length of Stay - statistics & numerical data</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mitral Valve Insufficiency - complications</topic><topic>Mitral Valve Insufficiency - surgery</topic><topic>Postoperative Complications - epidemiology</topic><topic>Proportional Hazards Models</topic><topic>Retrospective Studies</topic><topic>Risk</topic><topic>Stroke Volume</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Patel, Nishant D.</creatorcontrib><creatorcontrib>Williams, Jason A.</creatorcontrib><creatorcontrib>Nwakanma, Lois U.</creatorcontrib><creatorcontrib>Waldron, Michele M.</creatorcontrib><creatorcontrib>Bluemke, David A.</creatorcontrib><creatorcontrib>Conte, John V.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Annals of thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Patel, Nishant D.</au><au>Williams, Jason A.</au><au>Nwakanma, Lois U.</au><au>Waldron, Michele M.</au><au>Bluemke, David A.</au><au>Conte, John V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Surgical Ventricular Restoration for Advanced Congestive Heart Failure: Should Pulmonary Hypertension Be a Contraindication?</atitle><jtitle>The Annals of thoracic surgery</jtitle><addtitle>Ann Thorac Surg</addtitle><date>2006-09-01</date><risdate>2006</risdate><volume>82</volume><issue>3</issue><spage>879</spage><epage>888</epage><pages>879-888</pages><issn>0003-4975</issn><eissn>1552-6259</eissn><abstract>Surgical ventricular restoration (SVR) is an established therapy for congestive heart failure due to ischemic cardiomyopathy. Pulmonary hypertension (PHTN) has been considered a contraindication for SVR owing to a presumed increase in operative risk. However, outcomes in these patients and the impact of SVR on PHTN have not been specifically evaluated.
We retrospectively reviewed SVR patients between January 2002 and June 2005. Patients were classified as PHTN (mean pulmonary artery pressure ≥ 25 mm Hg) and no PHTN (mPAP < 25 mm Hg) based on preoperative cardiac catheterization. Cardiac function was assessed using magnetic resonance imaging and echocardiography. Follow-up was 100%.
Sixty-nine patients underwent SVR for congestive heart failure. Thirty-six percent (25 of 69) had preoperative PHTN. Preoperatively, PHTN patients had significantly lower ejection fraction (21.1% versus 30.0%;
p = 0.005) and larger left ventricular end-systolic volume index (119.0 versus 88.7 mL/m
2;
p = 0.04) than patients without PHTN. All PHTN patients and 95.5% (42 of 44) of the no PHTN group were New York Heart Association (NYHA) class III/IV preoperatively. There was 1 operative death in the PHTN group. Surgical ventricular restoration significantly improved cardiac function and pulmonary pressures for PHTN patients. Both groups had similar cardiac function postoperatively. Seventy-two percent (18 of 25) of PHTN patients and 69.0% (29 of 42) of patients without PHTN improved to NYHA class I/II at follow-up. Kaplan-Meier survival of PHTN patients was 68.1% at 3 years, which was lower than patients without PHTN (81.4%;
p = 0.44), but not statistically significant. Kaplan-Meier 3-year survival for all SVR patients was 76.6%.
Surgical ventricular restoration is a good treatment option in patients with advanced congestive heart failure and PHTN. Our early results are promising and should prompt further studies to confirm these findings.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>16928501</pmid><doi>10.1016/j.athoracsur.2006.04.016</doi><tpages>10</tpages></addata></record> |
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| subjects | Aged Cardiac Surgical Procedures Comorbidity Contraindications Coronary Artery Bypass - statistics & numerical data Female Heart Failure - complications Heart Failure - surgery Heart Ventricles - surgery Humans Hypertension, Pulmonary - complications Length of Stay - statistics & numerical data Male Middle Aged Mitral Valve Insufficiency - complications Mitral Valve Insufficiency - surgery Postoperative Complications - epidemiology Proportional Hazards Models Retrospective Studies Risk Stroke Volume Treatment Outcome |
| title | Surgical Ventricular Restoration for Advanced Congestive Heart Failure: Should Pulmonary Hypertension Be a Contraindication? |
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