Immunogenotype Changes Prevail in Relapses of Young Children with TEL-AML1-Positive Acute Lymphoblastic Leukemia and Derive Mainly from Clonal Selection

Purpose: Variations of the immunogenotype and TEL deletions in children with TEL-AML1 + acute lymphoblastic leukemia support the hypothesis that relapses derive from a persistent TEL-AML1 + preleukemic/leukemic clone rather than a resistant leukemia. We aimed at elucidating the relationship between...

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Veröffentlicht in:	Clinical cancer research 2005-11, Vol.11 (21), p.7720-7727
Hauptverfasser:	PANZER-GRUMAYER, E. Renate, CAZZANIGA, Giovanni, BASSO, Giuseppe, BIONDI, Andrea, VAN DONGEN, Jacques J. M, GADNER, Helmut, HAAS, Oskar A, VAN DER VELDEN, Vincent H. J, DEL GIUDICE, Laura, PEHAM, Martina, MANN, Georg, ECKERT, Conny, SCHRAUDER, Andre, GERMANO, Giuseppe, HARBOTT, Jochen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Age Factors Antibodies, Monoclonal - chemistry Antineoplastic agents B-Lymphocytes - metabolism Biological and medical sciences Bone Marrow Cells - cytology Child Child, Preschool Core Binding Factor Alpha 2 Subunit - biosynthesis Core Binding Factor Alpha 2 Subunit - genetics Gene Deletion Gene Rearrangement Genetic Techniques Genotype Hematologic and hematopoietic diseases Humans Immune System - pathology Immunoglobulins - chemistry Immunoglobulins - metabolism Infant Leukemias and lymphomas Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Oncogene Proteins, Fusion - biosynthesis Oncogene Proteins, Fusion - genetics Pharmacology. Drug treatments Polymerase Chain Reaction Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology Receptors, Antigen, T-Cell - genetics Recurrence Remission Induction Time Factors Translocation, Genetic
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