Plasmalemmal Vesicle Associated Protein-1 Is a Novel Marker Implicated in Brain Tumor Angiogenesis

Purpose: Plasmalemmal vesicle associated protein-1 ( PV-1 ) is up-regulated in the endothelium of human glioblastoma. We sought to further characterize the expression pattern of PV-1 in human brain tumors and interrogate its role in brain tumor angiogenesis. Experimental Design: Quantitative reverse...

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Veröffentlicht in:	Clinical cancer research 2005-11, Vol.11 (21), p.7643-7650
Hauptverfasser:	CARSON-WALTER, Eleanor B, HAMPTON, Jessic, SHUE, Eveline, GEYNISMAN, Daniel M, PRAMOD KUMAR PILLAI, SATHANOORI, Ramasri, MADDEN, Stephen L, HAMILTON, Ronald L, WALTER, Kevin A
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Biological and medical sciences Biomarkers, Tumor Blood-Brain Barrier Blotting, Western Brain Neoplasms - pathology Carrier Proteins - biosynthesis Cell Line, Tumor Cell Movement Cells, Cultured Collagen - chemistry Culture Media, Conditioned - pharmacology Drug Combinations Endothelium Endothelium, Vascular - cytology Endothelium, Vascular - pathology Gene Expression Regulation, Neoplastic Glioma Humans In Situ Hybridization Ischemia Laminin - chemistry Medical sciences Membrane Proteins - biosynthesis Microcirculation Neoplasm Metastasis Neovascularization, Pathologic Neurology Proteoglycans - chemistry PV-1 Reverse Transcriptase Polymerase Chain Reaction RNA - metabolism RNA Interference RNA, Messenger - metabolism RNA, Small Interfering - metabolism Transcription, Genetic Tumors of the nervous system. Phacomatoses Up-Regulation Vascular Endothelial Growth Factor A - metabolism
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