Cefuroxime axetil versus placebo for children with acute respiratory infection and imaging evidence of sinusitis: A randomized, controlled trial
Aim: To evaluate the efficacy of antibiotic treatment in children who presented in medical care with respiratory infection and had imaging evidence of sinusitis. Methods: Eighty‐two children (4–10 y) with acute respiratory symptoms and ultrasonography findings suggestive of acute rhinosinusitis were...
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| Veröffentlicht in: | Acta Paediatrica 2005-09, Vol.94 (9), p.1208-1213 |
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| container_title | Acta Paediatrica |
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| creator | Kristo, Aila Uhari, Matti Luotonen, Jukka Ilkko, Eero Koivunen, Petri Alho, Olli-Pekka |
| description | Aim: To evaluate the efficacy of antibiotic treatment in children who presented in medical care with respiratory infection and had imaging evidence of sinusitis. Methods: Eighty‐two children (4–10 y) with acute respiratory symptoms and ultrasonography findings suggestive of acute rhinosinusitis were enrolled in a randomized, double‐blind trial. The sinus findings were confirmed with plain radiographs. The children received either cefuroxime axetil in 125‐mg capsules twice a day for 10 d or placebo. Main outcome measures were complete cure in 2 wk and absence of prolonged symptoms or complications. Results: A total of 72 children (88%) completed follow‐up. The sinusitis findings in the ultrasound could be confirmed with plain radiographs in 65 of the 72 patients (90%). The proportion of children completely cured by day 14 was similar in both groups (difference 6%, 95% confidence interval −16% to 29%). Similarly, there was no significant difference in the proportions of children who escaped prolonged disease and complications between the groups (difference 7%, −9% to 24%).
Conclusion: A 10‐d course of cefuroxime axetil offered no clinical benefit to children with an acute respiratory illness and imaging evidence of acute sinusitis. |
| doi_str_mv | 10.1111/j.1651-2227.2005.tb02076.x |
| format | Article |
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Conclusion: A 10‐d course of cefuroxime axetil offered no clinical benefit to children with an acute respiratory illness and imaging evidence of acute sinusitis.</description><identifier>ISSN: 0803-5253</identifier><identifier>EISSN: 1651-2227</identifier><identifier>DOI: 10.1111/j.1651-2227.2005.tb02076.x</identifier><identifier>PMID: 16278986</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Acute Disease ; Anti-Bacterial Agents - therapeutic use ; Antibiotics ; Biological and medical sciences ; Cefuroxime - analogs & derivatives ; Cefuroxime - therapeutic use ; Child ; Child, Preschool ; children ; Double-Blind Method ; Female ; General aspects ; Humans ; Male ; Medical sciences ; Non tumoral diseases ; Otorhinolaryngology. Stomatology ; Placebos ; respiratory infection ; Respiratory Tract Infections - complications ; Respiratory Tract Infections - drug therapy ; rhinosinusitis ; Sinusitis - complications ; Sinusitis - drug therapy ; Time Factors ; Treatment Outcome ; trials ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>Acta Paediatrica, 2005-09, Vol.94 (9), p.1208-1213</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2868-7f94183a1389a1512470b006c8cde1df2ced6fefaf24bfe3f1d1a9c5305039e63</citedby><cites>FETCH-LOGICAL-c2868-7f94183a1389a1512470b006c8cde1df2ced6fefaf24bfe3f1d1a9c5305039e63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1651-2227.2005.tb02076.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1651-2227.2005.tb02076.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17173700$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16278986$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kristo, Aila</creatorcontrib><creatorcontrib>Uhari, Matti</creatorcontrib><creatorcontrib>Luotonen, Jukka</creatorcontrib><creatorcontrib>Ilkko, Eero</creatorcontrib><creatorcontrib>Koivunen, Petri</creatorcontrib><creatorcontrib>Alho, Olli-Pekka</creatorcontrib><title>Cefuroxime axetil versus placebo for children with acute respiratory infection and imaging evidence of sinusitis: A randomized, controlled trial</title><title>Acta Paediatrica</title><addtitle>Acta Paediatr</addtitle><description>Aim: To evaluate the efficacy of antibiotic treatment in children who presented in medical care with respiratory infection and had imaging evidence of sinusitis. Methods: Eighty‐two children (4–10 y) with acute respiratory symptoms and ultrasonography findings suggestive of acute rhinosinusitis were enrolled in a randomized, double‐blind trial. The sinus findings were confirmed with plain radiographs. The children received either cefuroxime axetil in 125‐mg capsules twice a day for 10 d or placebo. Main outcome measures were complete cure in 2 wk and absence of prolonged symptoms or complications. Results: A total of 72 children (88%) completed follow‐up. The sinusitis findings in the ultrasound could be confirmed with plain radiographs in 65 of the 72 patients (90%). The proportion of children completely cured by day 14 was similar in both groups (difference 6%, 95% confidence interval −16% to 29%). Similarly, there was no significant difference in the proportions of children who escaped prolonged disease and complications between the groups (difference 7%, −9% to 24%).
Conclusion: A 10‐d course of cefuroxime axetil offered no clinical benefit to children with an acute respiratory illness and imaging evidence of acute sinusitis.</description><subject>Acute Disease</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibiotics</subject><subject>Biological and medical sciences</subject><subject>Cefuroxime - analogs & derivatives</subject><subject>Cefuroxime - therapeutic use</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>children</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>General aspects</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Non tumoral diseases</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Placebos</subject><subject>respiratory infection</subject><subject>Respiratory Tract Infections - complications</subject><subject>Respiratory Tract Infections - drug therapy</subject><subject>rhinosinusitis</subject><subject>Sinusitis - complications</subject><subject>Sinusitis - drug therapy</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>trials</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>0803-5253</issn><issn>1651-2227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkc9u1DAQxiMEotvCKyALCU5k8Z_EcXqpVitaQFWhEgiJi-U449aLN15sp83yFDwyXu2qPTMXH-Y334y_ryheEzwnud6v5oTXpKSUNnOKcT1PHaa44fPpSTF7aD0tZlhgVta0ZkfFcYwrjClrK_68OCKcNqIVfFb8XYIZg5_sGpCaIFmH7iDEMaKNUxo6j4wPSN9a1wcY0L1Nt0jpMQEKEDc2qOTDFtnBgE7WD0gNPbJrdWOHGwR3todBA_IGRTuM0SYbT9EChUz5tf0D_Tuk_ZCCdw56lIJV7kXxzCgX4eXhPSm-n3_4tvxYXn65-LRcXJaaCi7KxrQVEUwRJlpFakKrBncYcy10D6Q3VEPPDRhlaNUZYIb0RLW6ZrjGrAXOToq3e91N8L9HiEmubdTgnBrAj1Fy0QiMmyqDp3tQBx9jACM3If8wbCXBcpeHXMmd6XJnutzlIQ95yCkPvzpsGbs19I-jhwAy8OYAqKiVM9kabeMj15CGNRhn7mzP3VsH2_84QS6-LgjFIiuUewUbE0wPCir8kjzvqOWPq4usd331-Vos5U_2D4pRuoc</recordid><startdate>200509</startdate><enddate>200509</enddate><creator>Kristo, Aila</creator><creator>Uhari, Matti</creator><creator>Luotonen, Jukka</creator><creator>Ilkko, Eero</creator><creator>Koivunen, Petri</creator><creator>Alho, Olli-Pekka</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200509</creationdate><title>Cefuroxime axetil versus placebo for children with acute respiratory infection and imaging evidence of sinusitis: A randomized, controlled trial</title><author>Kristo, Aila ; Uhari, Matti ; Luotonen, Jukka ; Ilkko, Eero ; Koivunen, Petri ; Alho, Olli-Pekka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2868-7f94183a1389a1512470b006c8cde1df2ced6fefaf24bfe3f1d1a9c5305039e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acute Disease</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antibiotics</topic><topic>Biological and medical sciences</topic><topic>Cefuroxime - analogs & derivatives</topic><topic>Cefuroxime - therapeutic use</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>children</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>General aspects</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Non tumoral diseases</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Placebos</topic><topic>respiratory infection</topic><topic>Respiratory Tract Infections - complications</topic><topic>Respiratory Tract Infections - drug therapy</topic><topic>rhinosinusitis</topic><topic>Sinusitis - complications</topic><topic>Sinusitis - drug therapy</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>trials</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kristo, Aila</creatorcontrib><creatorcontrib>Uhari, Matti</creatorcontrib><creatorcontrib>Luotonen, Jukka</creatorcontrib><creatorcontrib>Ilkko, Eero</creatorcontrib><creatorcontrib>Koivunen, Petri</creatorcontrib><creatorcontrib>Alho, Olli-Pekka</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta Paediatrica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kristo, Aila</au><au>Uhari, Matti</au><au>Luotonen, Jukka</au><au>Ilkko, Eero</au><au>Koivunen, Petri</au><au>Alho, Olli-Pekka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cefuroxime axetil versus placebo for children with acute respiratory infection and imaging evidence of sinusitis: A randomized, controlled trial</atitle><jtitle>Acta Paediatrica</jtitle><addtitle>Acta Paediatr</addtitle><date>2005-09</date><risdate>2005</risdate><volume>94</volume><issue>9</issue><spage>1208</spage><epage>1213</epage><pages>1208-1213</pages><issn>0803-5253</issn><eissn>1651-2227</eissn><abstract>Aim: To evaluate the efficacy of antibiotic treatment in children who presented in medical care with respiratory infection and had imaging evidence of sinusitis. Methods: Eighty‐two children (4–10 y) with acute respiratory symptoms and ultrasonography findings suggestive of acute rhinosinusitis were enrolled in a randomized, double‐blind trial. The sinus findings were confirmed with plain radiographs. The children received either cefuroxime axetil in 125‐mg capsules twice a day for 10 d or placebo. Main outcome measures were complete cure in 2 wk and absence of prolonged symptoms or complications. Results: A total of 72 children (88%) completed follow‐up. The sinusitis findings in the ultrasound could be confirmed with plain radiographs in 65 of the 72 patients (90%). The proportion of children completely cured by day 14 was similar in both groups (difference 6%, 95% confidence interval −16% to 29%). Similarly, there was no significant difference in the proportions of children who escaped prolonged disease and complications between the groups (difference 7%, −9% to 24%).
Conclusion: A 10‐d course of cefuroxime axetil offered no clinical benefit to children with an acute respiratory illness and imaging evidence of acute sinusitis.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>16278986</pmid><doi>10.1111/j.1651-2227.2005.tb02076.x</doi><tpages>6</tpages></addata></record> |
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| subjects | Acute Disease Anti-Bacterial Agents - therapeutic use Antibiotics Biological and medical sciences Cefuroxime - analogs & derivatives Cefuroxime - therapeutic use Child Child, Preschool children Double-Blind Method Female General aspects Humans Male Medical sciences Non tumoral diseases Otorhinolaryngology. Stomatology Placebos respiratory infection Respiratory Tract Infections - complications Respiratory Tract Infections - drug therapy rhinosinusitis Sinusitis - complications Sinusitis - drug therapy Time Factors Treatment Outcome trials Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Cefuroxime axetil versus placebo for children with acute respiratory infection and imaging evidence of sinusitis: A randomized, controlled trial |
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