Analysis of pThr286-CaMKII and CaMKII immunohistochemistry in the hippocampus of patients with temporal lobe epilepsy

Ca2+/calmodulin-dependent protein kinase II (CaMKII) phosphorylates a variety of neuronal proteins, thereby, coordinating responses to changes of intracellular Ca2+ concentrations. Autophosphorylation at threonine286 generates an autonomously active form of CaMKII (pThr286-CaMKII), thus prolonging r...

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Veröffentlicht in:	Epilepsy research 2005-10, Vol.67 (1-2), p.13-23
Hauptverfasser:	LIE, Ailing A, SOMMERSBERG, Britta, ELGER, Christian E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Calcium-Calmodulin-Dependent Protein Kinase Type 2 Calcium-Calmodulin-Dependent Protein Kinases - metabolism Enzyme Activation Epilepsy, Temporal Lobe - metabolism Epilepsy, Temporal Lobe - pathology Female Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hippocampus - enzymology Hippocampus - pathology Humans Immunohistochemistry Male Medical sciences Middle Aged Nervous system (semeiology, syndromes) Neurology Neuropharmacology Pharmacology. Drug treatments Phosphorylation Sclerosis Threonine - metabolism
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