Age and sex differences in the locomotor effect of repeated methylphenidate in rats classified as high or low novelty responders
Rats displaying high levels of activity in an inescapable novel environment (high responders; HR) are more sensitive to the locomotor effect of stimulant drugs than rats displaying low levels of activity (low responders; LR). The current study determined the age- and sex-dependent locomotor effects...
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| Veröffentlicht in: | Psychopharmacologia 2006-09, Vol.188 (1), p.18-27 |
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| creator | WOOTERS, T. E DWOSKIN, L. P BARDO, M. T |
| description | Rats displaying high levels of activity in an inescapable novel environment (high responders; HR) are more sensitive to the locomotor effect of stimulant drugs than rats displaying low levels of activity (low responders; LR).
The current study determined the age- and sex-dependent locomotor effects of repeated methylphenidate in HR and LR rats.
Periadolescent and adult male and female Sprague-Dawley rats were first classified as HR or LR; rats were also classified as high or low novelty seekers based on free-choice preference for a novel environment. Locomotor activity was subsequently assessed after ten daily injections of methylphenidate (3 or 10 mg/kg s.c.) or saline. Fifteen days later, rats were challenged with saline and methylphenidate (10 mg/kg) over 2 days.
During the repeated methylphenidate treatment phase, adult females showed greater methylphenidate-induced hyperactivity than adult males; there was no reliable difference in methylphenidate-induced hyperactivity between HR and LR rats of either age or sex. However, periadolescent male HR rats given repeated methylphenidate showed greater conditioned hyperactivity after the saline challenge than periadolescent male LR rats. Further, adult female HR rats given repeated methylphenidate showed greater conditioned hyperactivity and sensitization than adult female LR rats. In contrast, although free-choice novelty preference was greater among periadolescents than adults, individual differences in this variable did not predict the effect of repeated methylphenidate during any phase of the experiment.
Although individual differences in response to inescapable novelty predict methylphenidate-induced conditioned hyperactivity and sensitization, this relationship is moderated by age and sex. |
| doi_str_mv | 10.1007/s00213-006-0445-9 |
| format | Article |
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The current study determined the age- and sex-dependent locomotor effects of repeated methylphenidate in HR and LR rats.
Periadolescent and adult male and female Sprague-Dawley rats were first classified as HR or LR; rats were also classified as high or low novelty seekers based on free-choice preference for a novel environment. Locomotor activity was subsequently assessed after ten daily injections of methylphenidate (3 or 10 mg/kg s.c.) or saline. Fifteen days later, rats were challenged with saline and methylphenidate (10 mg/kg) over 2 days.
During the repeated methylphenidate treatment phase, adult females showed greater methylphenidate-induced hyperactivity than adult males; there was no reliable difference in methylphenidate-induced hyperactivity between HR and LR rats of either age or sex. However, periadolescent male HR rats given repeated methylphenidate showed greater conditioned hyperactivity after the saline challenge than periadolescent male LR rats. Further, adult female HR rats given repeated methylphenidate showed greater conditioned hyperactivity and sensitization than adult female LR rats. In contrast, although free-choice novelty preference was greater among periadolescents than adults, individual differences in this variable did not predict the effect of repeated methylphenidate during any phase of the experiment.
Although individual differences in response to inescapable novelty predict methylphenidate-induced conditioned hyperactivity and sensitization, this relationship is moderated by age and sex.</description><identifier>ISSN: 0033-3158</identifier><identifier>EISSN: 1432-2072</identifier><identifier>DOI: 10.1007/s00213-006-0445-9</identifier><identifier>PMID: 16896959</identifier><identifier>CODEN: PSYPAG</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Age ; Age Factors ; Aging ; Animal behavior ; Animals ; Behavior, Animal - drug effects ; Biological and medical sciences ; Central Nervous System Stimulants - pharmacology ; Dose-Response Relationship, Drug ; Exploratory Behavior - drug effects ; Female ; Gender differences ; Hyperactivity ; Male ; Medical sciences ; Methylphenidate - pharmacology ; Motor ability ; Motor Activity - drug effects ; Neuropharmacology ; Pharmacology ; Pharmacology. Drug treatments ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Rats ; Rats, Sprague-Dawley ; Rodents ; Sex Characteristics ; Sex Factors ; Time Factors</subject><ispartof>Psychopharmacologia, 2006-09, Vol.188 (1), p.18-27</ispartof><rights>2006 INIST-CNRS</rights><rights>Springer-Verlag 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-480f576924af57a2a45300ef04d65122545203c86030d88885808c9a974e2f403</citedby><cites>FETCH-LOGICAL-c387t-480f576924af57a2a45300ef04d65122545203c86030d88885808c9a974e2f403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18092800$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16896959$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WOOTERS, T. E</creatorcontrib><creatorcontrib>DWOSKIN, L. P</creatorcontrib><creatorcontrib>BARDO, M. T</creatorcontrib><title>Age and sex differences in the locomotor effect of repeated methylphenidate in rats classified as high or low novelty responders</title><title>Psychopharmacologia</title><addtitle>Psychopharmacology (Berl)</addtitle><description>Rats displaying high levels of activity in an inescapable novel environment (high responders; HR) are more sensitive to the locomotor effect of stimulant drugs than rats displaying low levels of activity (low responders; LR).
The current study determined the age- and sex-dependent locomotor effects of repeated methylphenidate in HR and LR rats.
Periadolescent and adult male and female Sprague-Dawley rats were first classified as HR or LR; rats were also classified as high or low novelty seekers based on free-choice preference for a novel environment. Locomotor activity was subsequently assessed after ten daily injections of methylphenidate (3 or 10 mg/kg s.c.) or saline. Fifteen days later, rats were challenged with saline and methylphenidate (10 mg/kg) over 2 days.
During the repeated methylphenidate treatment phase, adult females showed greater methylphenidate-induced hyperactivity than adult males; there was no reliable difference in methylphenidate-induced hyperactivity between HR and LR rats of either age or sex. However, periadolescent male HR rats given repeated methylphenidate showed greater conditioned hyperactivity after the saline challenge than periadolescent male LR rats. Further, adult female HR rats given repeated methylphenidate showed greater conditioned hyperactivity and sensitization than adult female LR rats. In contrast, although free-choice novelty preference was greater among periadolescents than adults, individual differences in this variable did not predict the effect of repeated methylphenidate during any phase of the experiment.
Although individual differences in response to inescapable novelty predict methylphenidate-induced conditioned hyperactivity and sensitization, this relationship is moderated by age and sex.</description><subject>Age</subject><subject>Age Factors</subject><subject>Aging</subject><subject>Animal behavior</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Central Nervous System Stimulants - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Exploratory Behavior - drug effects</subject><subject>Female</subject><subject>Gender differences</subject><subject>Hyperactivity</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methylphenidate - pharmacology</subject><subject>Motor ability</subject><subject>Motor Activity - drug effects</subject><subject>Neuropharmacology</subject><subject>Pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rodents</subject><subject>Sex Characteristics</subject><subject>Sex Factors</subject><subject>Time Factors</subject><issn>0033-3158</issn><issn>1432-2072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU2LFDEQhoMo7rj6A7xIEPTWWvnqTo7L4hcseNFziOnKdi_dnTbVozs3f7oZZmDBi3UpSJ73heJh7KWAdwKge08AUqgGoG1Aa9O4R2wntJKNhE4-ZjsApRoljL1gz4juoI62-im7EK11rTNux_5c3SIPS88J73k_poQFl4jEx4VvA_IpxzznLReO9S9uPCdecMWwYc9n3IbDtA64jH19OGZK2IjHKRCNaaxIID6MtwOvBVP-zZf8C6ftUCtozUuPhZ6zJylMhC_O-5J9__jh2_Xn5ubrpy_XVzdNVLbbGm0hma51Uoe6gwzaKABMoPvWCCmNNhJUtC0o6G0dY8FGF1ynUSYN6pK9PfWuJf_cI21-HiniNIUF8558a7vOSmH-C0qwVoA9Nr7-B7zL-7LUI7wU1nVSKVkhcYJiyUQFk1_LOIdy8AL8UaI_SfRVoj9K9K5mXp2L9z9m7B8SZ2sVeHMGAsUwpRKWONIDZ8FJW-X_BaNxo4I</recordid><startdate>20060901</startdate><enddate>20060901</enddate><creator>WOOTERS, T. 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Drug treatments</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rodents</topic><topic>Sex Characteristics</topic><topic>Sex Factors</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WOOTERS, T. E</creatorcontrib><creatorcontrib>DWOSKIN, L. P</creatorcontrib><creatorcontrib>BARDO, M. 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E</au><au>DWOSKIN, L. P</au><au>BARDO, M. T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age and sex differences in the locomotor effect of repeated methylphenidate in rats classified as high or low novelty responders</atitle><jtitle>Psychopharmacologia</jtitle><addtitle>Psychopharmacology (Berl)</addtitle><date>2006-09-01</date><risdate>2006</risdate><volume>188</volume><issue>1</issue><spage>18</spage><epage>27</epage><pages>18-27</pages><issn>0033-3158</issn><eissn>1432-2072</eissn><coden>PSYPAG</coden><abstract>Rats displaying high levels of activity in an inescapable novel environment (high responders; HR) are more sensitive to the locomotor effect of stimulant drugs than rats displaying low levels of activity (low responders; LR).
The current study determined the age- and sex-dependent locomotor effects of repeated methylphenidate in HR and LR rats.
Periadolescent and adult male and female Sprague-Dawley rats were first classified as HR or LR; rats were also classified as high or low novelty seekers based on free-choice preference for a novel environment. Locomotor activity was subsequently assessed after ten daily injections of methylphenidate (3 or 10 mg/kg s.c.) or saline. Fifteen days later, rats were challenged with saline and methylphenidate (10 mg/kg) over 2 days.
During the repeated methylphenidate treatment phase, adult females showed greater methylphenidate-induced hyperactivity than adult males; there was no reliable difference in methylphenidate-induced hyperactivity between HR and LR rats of either age or sex. However, periadolescent male HR rats given repeated methylphenidate showed greater conditioned hyperactivity after the saline challenge than periadolescent male LR rats. Further, adult female HR rats given repeated methylphenidate showed greater conditioned hyperactivity and sensitization than adult female LR rats. In contrast, although free-choice novelty preference was greater among periadolescents than adults, individual differences in this variable did not predict the effect of repeated methylphenidate during any phase of the experiment.
Although individual differences in response to inescapable novelty predict methylphenidate-induced conditioned hyperactivity and sensitization, this relationship is moderated by age and sex.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>16896959</pmid><doi>10.1007/s00213-006-0445-9</doi><tpages>10</tpages></addata></record> |
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| subjects | Age Age Factors Aging Animal behavior Animals Behavior, Animal - drug effects Biological and medical sciences Central Nervous System Stimulants - pharmacology Dose-Response Relationship, Drug Exploratory Behavior - drug effects Female Gender differences Hyperactivity Male Medical sciences Methylphenidate - pharmacology Motor ability Motor Activity - drug effects Neuropharmacology Pharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Sprague-Dawley Rodents Sex Characteristics Sex Factors Time Factors |
| title | Age and sex differences in the locomotor effect of repeated methylphenidate in rats classified as high or low novelty responders |
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