Mucosa-associated Lymphoid Tissue Lymphoma of the Lacrimal Gland - A Case Report
MALT lymphoma of the ocular adnexa, an indolent B-cell lymphoma, rarely affects the lacrimal gland. The case of a 73-year-old man with ptosis and edema of the left upper eyelid, due to lacrimal gland swelling, is presented. Clinical evaluation and imaging examination led to excision biopsy. The mass...
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| Veröffentlicht in: | In vivo (Athens) 2005-11, Vol.19 (6), p.1105-1109 |
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| container_title | In vivo (Athens) |
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| creator | Asproudis, Ioannis Gorezis, Spiridon Charonis, Georgios C Tolis, Christos Tsanou, Elena Elena, Tsanou Agnantis, Niki J |
| description | MALT lymphoma of the ocular adnexa, an indolent B-cell lymphoma, rarely affects the lacrimal gland. The case of a 73-year-old
man with ptosis and edema of the left upper eyelid, due to lacrimal gland swelling, is presented. Clinical evaluation and
imaging examination led to excision biopsy. The mass histopathology, presenting organized lymphoid tissue, composed mainly
of small B-cells, accompanied by immunophenotypic characteristics, was compatible with MALT lymphoma. Treatment with monoclonal
antibody against CD-20 achieved a successful long-term disease control (4 years). The diagnostic approach is described and
the pathological features and clinical signs of this rare entity are discussed, based on recent literature. The indolent clinical
course of this lymphoma, either remaining localized or disseminating to other mucosal sites, is a distinct characteristic
affecting prognosis. |
| format | Article |
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man with ptosis and edema of the left upper eyelid, due to lacrimal gland swelling, is presented. Clinical evaluation and
imaging examination led to excision biopsy. The mass histopathology, presenting organized lymphoid tissue, composed mainly
of small B-cells, accompanied by immunophenotypic characteristics, was compatible with MALT lymphoma. Treatment with monoclonal
antibody against CD-20 achieved a successful long-term disease control (4 years). The diagnostic approach is described and
the pathological features and clinical signs of this rare entity are discussed, based on recent literature. The indolent clinical
course of this lymphoma, either remaining localized or disseminating to other mucosal sites, is a distinct characteristic
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man with ptosis and edema of the left upper eyelid, due to lacrimal gland swelling, is presented. Clinical evaluation and
imaging examination led to excision biopsy. The mass histopathology, presenting organized lymphoid tissue, composed mainly
of small B-cells, accompanied by immunophenotypic characteristics, was compatible with MALT lymphoma. Treatment with monoclonal
antibody against CD-20 achieved a successful long-term disease control (4 years). The diagnostic approach is described and
the pathological features and clinical signs of this rare entity are discussed, based on recent literature. The indolent clinical
course of this lymphoma, either remaining localized or disseminating to other mucosal sites, is a distinct characteristic
affecting prognosis.</description><subject>Aged</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Antibodies, Monoclonal - therapeutic use</subject><subject>Antibodies, Monoclonal, Murine-Derived</subject><subject>Antigens, CD20 - metabolism</subject><subject>Biopsy</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lacrimal Apparatus - diagnostic imaging</subject><subject>Lacrimal Apparatus - pathology</subject><subject>Lacrimal Apparatus - surgery</subject><subject>Lymphoma, B-Cell, Marginal Zone - diagnosis</subject><subject>Lymphoma, B-Cell, Marginal Zone - diagnostic imaging</subject><subject>Lymphoma, B-Cell, Marginal Zone - pathology</subject><subject>Lymphoma, B-Cell, Marginal Zone - surgery</subject><subject>Male</subject><subject>Methylprednisolone - therapeutic use</subject><subject>Rituximab</subject><subject>Time Factors</subject><subject>Tomography, X-Ray Computed</subject><subject>Treatment Outcome</subject><issn>0258-851X</issn><issn>1791-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kNFLwzAYxIMobk7_BcmLvhW-JKZJHsfQKUwUmeBbSJuvNtKa2rTK_nsrm0_HwY_j7o7InCnDMiVvzDGZA5c605K9zchZSh8AuQLgp2TGcq4UCDYnz49jGZPLXEqxDG5ATze7tqtj8HQbUhrx4FtHY0WHevKu7EPrGrpu3KenGV3SlUtIX7CL_XBOTirXJLw46IK83t1uV_fZ5mn9sFpuspoLM2QSK1-BVkpyIbw2pS8k07kptQLDhXKFR2ACZJE7Ayo3HDQKKT1wrwtEsSDX-9yuj18jpsG2IZXYTJ0wjsnmU7YGUBN4eQDHokVvu7_y_c7-fzABV3ugDu_1T-jRpmldM-HChm9mbG4ZAyl-AblcZFM</recordid><startdate>20051101</startdate><enddate>20051101</enddate><creator>Asproudis, Ioannis</creator><creator>Gorezis, Spiridon</creator><creator>Charonis, Georgios C</creator><creator>Tolis, Christos</creator><creator>Tsanou, Elena</creator><creator>Elena, Tsanou</creator><creator>Agnantis, Niki J</creator><general>International Institute of Anticancer Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20051101</creationdate><title>Mucosa-associated Lymphoid Tissue Lymphoma of the Lacrimal Gland - A Case Report</title><author>Asproudis, Ioannis ; Gorezis, Spiridon ; Charonis, Georgios C ; Tolis, Christos ; Tsanou, Elena ; Elena, Tsanou ; Agnantis, Niki J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h239t-5efdf08775233d89cdb51869c8709237abde01305b6a90769208e355d02d8bee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aged</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Antibodies, Monoclonal - therapeutic use</topic><topic>Antibodies, Monoclonal, Murine-Derived</topic><topic>Antigens, CD20 - metabolism</topic><topic>Biopsy</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lacrimal Apparatus - diagnostic imaging</topic><topic>Lacrimal Apparatus - pathology</topic><topic>Lacrimal Apparatus - surgery</topic><topic>Lymphoma, B-Cell, Marginal Zone - diagnosis</topic><topic>Lymphoma, B-Cell, Marginal Zone - diagnostic imaging</topic><topic>Lymphoma, B-Cell, Marginal Zone - pathology</topic><topic>Lymphoma, B-Cell, Marginal Zone - surgery</topic><topic>Male</topic><topic>Methylprednisolone - therapeutic use</topic><topic>Rituximab</topic><topic>Time Factors</topic><topic>Tomography, X-Ray Computed</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Asproudis, Ioannis</creatorcontrib><creatorcontrib>Gorezis, Spiridon</creatorcontrib><creatorcontrib>Charonis, Georgios C</creatorcontrib><creatorcontrib>Tolis, Christos</creatorcontrib><creatorcontrib>Tsanou, Elena</creatorcontrib><creatorcontrib>Elena, Tsanou</creatorcontrib><creatorcontrib>Agnantis, Niki J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>In vivo (Athens)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Asproudis, Ioannis</au><au>Gorezis, Spiridon</au><au>Charonis, Georgios C</au><au>Tolis, Christos</au><au>Tsanou, Elena</au><au>Elena, Tsanou</au><au>Agnantis, Niki J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mucosa-associated Lymphoid Tissue Lymphoma of the Lacrimal Gland - A Case Report</atitle><jtitle>In vivo (Athens)</jtitle><addtitle>In Vivo</addtitle><date>2005-11-01</date><risdate>2005</risdate><volume>19</volume><issue>6</issue><spage>1105</spage><epage>1109</epage><pages>1105-1109</pages><issn>0258-851X</issn><eissn>1791-7549</eissn><abstract>MALT lymphoma of the ocular adnexa, an indolent B-cell lymphoma, rarely affects the lacrimal gland. The case of a 73-year-old
man with ptosis and edema of the left upper eyelid, due to lacrimal gland swelling, is presented. Clinical evaluation and
imaging examination led to excision biopsy. The mass histopathology, presenting organized lymphoid tissue, composed mainly
of small B-cells, accompanied by immunophenotypic characteristics, was compatible with MALT lymphoma. Treatment with monoclonal
antibody against CD-20 achieved a successful long-term disease control (4 years). The diagnostic approach is described and
the pathological features and clinical signs of this rare entity are discussed, based on recent literature. The indolent clinical
course of this lymphoma, either remaining localized or disseminating to other mucosal sites, is a distinct characteristic
affecting prognosis.</abstract><cop>Greece</cop><pub>International Institute of Anticancer Research</pub><pmid>16277031</pmid><tpages>5</tpages></addata></record> |
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| subjects | Aged Anti-Inflammatory Agents - therapeutic use Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Murine-Derived Antigens, CD20 - metabolism Biopsy Follow-Up Studies Humans Immunohistochemistry Lacrimal Apparatus - diagnostic imaging Lacrimal Apparatus - pathology Lacrimal Apparatus - surgery Lymphoma, B-Cell, Marginal Zone - diagnosis Lymphoma, B-Cell, Marginal Zone - diagnostic imaging Lymphoma, B-Cell, Marginal Zone - pathology Lymphoma, B-Cell, Marginal Zone - surgery Male Methylprednisolone - therapeutic use Rituximab Time Factors Tomography, X-Ray Computed Treatment Outcome |
| title | Mucosa-associated Lymphoid Tissue Lymphoma of the Lacrimal Gland - A Case Report |
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