Pharmacological Targeting of Adipocytes/Fat Metabolism for Treatment of Obesity and Diabetes
Obesity is now recognized as a rapidly increasing worldwide threat to health, largely as a result of causing diabetes. Thus, considerable efforts are underway in the pharmaceutical industry to find drugs to treat this condition. Target validation in various academic and industrial laboratories has r...
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| Veröffentlicht in: | Molecular pharmacology 2006-09, Vol.70 (3), p.779-785 |
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| container_title | Molecular pharmacology |
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| creator | Pilch, Paul F. Bergenhem, Nils |
| description | Obesity is now recognized as a rapidly increasing worldwide threat to health, largely as a result of causing diabetes. Thus, considerable efforts are underway in the pharmaceutical industry to find drugs to treat this condition. Target validation in various academic and industrial laboratories has revealed a number of potential molecular targets in fat cells or adipocytes. By definition, obesity is too much fat, and we here review efforts to treat obesity and, by proxy, diabetes by modulating the metabolic state of adipocytes. |
| doi_str_mv | 10.1124/mol.106.026104 |
| format | Article |
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By definition, obesity is too much fat, and we here review efforts to treat obesity and, by proxy, diabetes by modulating the metabolic state of adipocytes.</description><subject>Adipocytes - metabolism</subject><subject>Animals</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Energy Metabolism</subject><subject>Humans</subject><subject>Lipid Metabolism</subject><subject>Obesity - drug therapy</subject><issn>0026-895X</issn><issn>1521-0111</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM9rFDEUx4NY7Fq9epS56G22yfxIJsfSWhVa2sMWPAjhJXnZjcxM1iSr7H9vyiz05Ok9Hp_vl8eHkA-MrhlrusspjGtG-Zo2nNHuFVmxvmE1ZYy9JitarvUg-x_n5G1KvyhlXT_QN-ScccFpy-mK_HzcQZzAhDFsvYGx2kDcYvbztgquurJ-H8wxY7q8hVzdYwYdRp-myoVYbSJCnnDOz-iDxuTzsYLZVjceNJbQO3LmYEz4_jQvyNPtl831t_ru4ev366u72nTtkGtOrRW21VJKhtoiSDm41uAgXdODHVCyVjDdCSmsYwKc7FvLKWiD0Gjh2gvyeendx_D7gCmrySeD4wgzhkNSfBCCy64r4HoBTQwpRXRqH_0E8agYVc8-VfFZdq4WnyXw8dR80BPaF_wksACfFmDnt7u_PqLavwg9KkFVq4SQhRsWDouHPx6jSsbjbNCWjMnKBv-_H_4BOy6Sgg</recordid><startdate>20060901</startdate><enddate>20060901</enddate><creator>Pilch, Paul F.</creator><creator>Bergenhem, Nils</creator><general>Elsevier Inc</general><general>American Society for Pharmacology and Experimental Therapeutics</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060901</creationdate><title>Pharmacological Targeting of Adipocytes/Fat Metabolism for Treatment of Obesity and Diabetes</title><author>Pilch, Paul F. ; Bergenhem, Nils</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-60dd7d3b9991ebdea998f3ce89f25ad8e91371b4797df17af953d60abcea2b7f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adipocytes - metabolism</topic><topic>Animals</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Energy Metabolism</topic><topic>Humans</topic><topic>Lipid Metabolism</topic><topic>Obesity - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pilch, Paul F.</creatorcontrib><creatorcontrib>Bergenhem, Nils</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pilch, Paul F.</au><au>Bergenhem, Nils</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacological Targeting of Adipocytes/Fat Metabolism for Treatment of Obesity and Diabetes</atitle><jtitle>Molecular pharmacology</jtitle><addtitle>Mol Pharmacol</addtitle><date>2006-09-01</date><risdate>2006</risdate><volume>70</volume><issue>3</issue><spage>779</spage><epage>785</epage><pages>779-785</pages><issn>0026-895X</issn><eissn>1521-0111</eissn><abstract>Obesity is now recognized as a rapidly increasing worldwide threat to health, largely as a result of causing diabetes. 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| ispartof | Molecular pharmacology, 2006-09, Vol.70 (3), p.779-785 |
| issn | 0026-895X 1521-0111 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Adipocytes - metabolism Animals Diabetes Mellitus, Type 2 - drug therapy Energy Metabolism Humans Lipid Metabolism Obesity - drug therapy |
| title | Pharmacological Targeting of Adipocytes/Fat Metabolism for Treatment of Obesity and Diabetes |
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