Selective Peptide Chain Extension at the N-terminus of Aspartic and Glutamic Acids Utilizing 1-(N-protected-α-aminoacyl)benzotriazoles

Diverse N‐protected di‐(3a–d, 3a + a′, 5a–d, 5d + d′, and 7a–g) and tripeptides (10a–h) were synthesized under mild reaction conditions in good yields (65–97%) by acylation with 1‐(N‐protected‐α‐aminoacyl)benzotriazoles of the amino groups of free aspartic and glutamic acids. Complete retention of c...

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