A population model of prostate cancer incidence

Introduction of screening for prostate cancer using the prostate‐specific antigen (PSA) marker of the disease led to remarkable dynamics of the incidence of the disease observed in the last two decades. A statistical model is used to provide a link between dissemination of PSA and the observed trans...

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Veröffentlicht in:	Statistics in medicine 2006-08, Vol.25 (16), p.2846-2866
Hauptverfasser:	Tsodikov, A., Szabo, A., Wegelin, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age of Onset Aged Antigens Biometry Correlation analysis Estimating techniques Humans Male Mass Screening - statistics & numerical data Medical screening Middle Aged mixture models Models, Statistical Population Prostate cancer Prostate-Specific Antigen - blood Prostatic Neoplasms - blood Prostatic Neoplasms - diagnosis Prostatic Neoplasms - epidemiology screening SEER Program Statistical methods Time Factors United States - epidemiology
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Beschreibung
Zusammenfassung:	Introduction of screening for prostate cancer using the prostate‐specific antigen (PSA) marker of the disease led to remarkable dynamics of the incidence of the disease observed in the last two decades. A statistical model is used to provide a link between dissemination of PSA and the observed transient population responses. The model is used to estimate lead time, overdiagnosis and other relevant characteristics of prostate cancer screening. Copyright © 2006 John Wiley & Sons, Ltd.
ISSN:	0277-6715 1097-0258
DOI:	10.1002/sim.2257