One-year follow-up of transcoronary sinus administration of autologous bone marrow in patients with chronic refractory angina
Based on our preclinic studies with autologous unfractionated bone marrow (AUBM) via coronary sinus with transitory occlusion, a clinic study in patients with chronic refractory angina was designed. The objectives were to evaluate tolerance of the procedure, safety, and feasibility with 1 year follo...
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| Veröffentlicht in: | Cardiovascular revascularization medicine 2005-07, Vol.6 (3), p.99-107 |
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| creator | Vicario, Jose Campo, Cesar Piva, Julio Faccio, Fernando Gerardo, Luis Becker, Carlos Ortega, Hugo Pierini, Angel Lofeudo, Carlos Novero, Rafael Baliño, Nestor Perez Monti, Adrian Benech, Rodolfo Dallo, Matias Pfeiffer, Hernan |
| description | Based on our preclinic studies with autologous unfractionated bone marrow (AUBM) via coronary sinus with transitory occlusion, a clinic study in patients with chronic refractory angina was designed. The objectives were to evaluate tolerance of the procedure, safety, and feasibility with 1 year follow-up.
Clinical study with inclusion and exclusion criteria defined by an Independent Clinical Committee was carried out. Fifteen patients underwent transcoronary sinus administration with a 15-min occlusion of freshly aspirated and filtered AUBM (60–120 ml). Feasibility was evaluated with Seattle Angina Questionnaire (SAQ), Canadian Cardiovascular Society (CCS) angina classification, perfusion dipyridamole, and coronary angiography.
There were no changes in the tolerance parameters. There were no deaths or myocardial infarction during the follow-up. Three patients were readmitted into the hospital. During the follow-up, one patient was diagnosed with cancer of the lung. Improvement of 30% in the quality of life was evaluated by SAQ. The CCS angina classification showed that the mean angina class was 3.0±0.53 at baseline, which improved to 1.6±0.63 at 1 year (
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| doi_str_mv | 10.1016/j.carrev.2005.08.002 |
| format | Article |
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Clinical study with inclusion and exclusion criteria defined by an Independent Clinical Committee was carried out. Fifteen patients underwent transcoronary sinus administration with a 15-min occlusion of freshly aspirated and filtered AUBM (60–120 ml). Feasibility was evaluated with Seattle Angina Questionnaire (SAQ), Canadian Cardiovascular Society (CCS) angina classification, perfusion dipyridamole, and coronary angiography.
There were no changes in the tolerance parameters. There were no deaths or myocardial infarction during the follow-up. Three patients were readmitted into the hospital. During the follow-up, one patient was diagnosed with cancer of the lung. Improvement of 30% in the quality of life was evaluated by SAQ. The CCS angina classification showed that the mean angina class was 3.0±0.53 at baseline, which improved to 1.6±0.63 at 1 year (
P<.001).
Perfusion imaging (core lab) showed improvement in 12 of 15 patients, with a mean improvement of 40.9% at rest (22 vs. 13) (
P<.01) and 45.3% at stress (26.5 vs. 14.5) (
P<.05). Coronary angiography showed more collateral vessels in 10 of 15 patients.
We can conclude that AUBM via coronary sinus is feasible in patients with chronic refractory angina after 1 year follow-up, and it appears to be safe.</description><identifier>ISSN: 1553-8389</identifier><identifier>EISSN: 1878-0938</identifier><identifier>DOI: 10.1016/j.carrev.2005.08.002</identifier><identifier>PMID: 16275605</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Angina Pectoris - pathology ; Angina Pectoris - physiopathology ; Angina Pectoris - surgery ; Angiogenesis ; Autologous bone marrow ; Bone Marrow Transplantation ; Chronic refractory angina ; Collateral circulation ; Coronary Angiography ; Coronary Circulation ; Coronary sinus ; Coronary Stenosis - pathology ; Coronary Stenosis - physiopathology ; Coronary Stenosis - surgery ; Feasibility Studies ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Myocardial Reperfusion ; No option patients ; Patient Readmission ; Pilot Projects ; Prospective Studies ; Quality of Life ; Sickness Impact Profile ; Time Factors ; Tomography, Emission-Computed, Single-Photon ; Transplantation, Autologous ; Treatment Outcome ; Unfractionated bone marrow</subject><ispartof>Cardiovascular revascularization medicine, 2005-07, Vol.6 (3), p.99-107</ispartof><rights>2005 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-6e0ba86c5d94ca42d163b71eba6e9059d9b292c5078adaee488b8a713d26e4c63</citedby><cites>FETCH-LOGICAL-c406t-6e0ba86c5d94ca42d163b71eba6e9059d9b292c5078adaee488b8a713d26e4c63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.carrev.2005.08.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16275605$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vicario, Jose</creatorcontrib><creatorcontrib>Campo, Cesar</creatorcontrib><creatorcontrib>Piva, Julio</creatorcontrib><creatorcontrib>Faccio, Fernando</creatorcontrib><creatorcontrib>Gerardo, Luis</creatorcontrib><creatorcontrib>Becker, Carlos</creatorcontrib><creatorcontrib>Ortega, Hugo</creatorcontrib><creatorcontrib>Pierini, Angel</creatorcontrib><creatorcontrib>Lofeudo, Carlos</creatorcontrib><creatorcontrib>Novero, Rafael</creatorcontrib><creatorcontrib>Baliño, Nestor Perez</creatorcontrib><creatorcontrib>Monti, Adrian</creatorcontrib><creatorcontrib>Benech, Rodolfo</creatorcontrib><creatorcontrib>Dallo, Matias</creatorcontrib><creatorcontrib>Pfeiffer, Hernan</creatorcontrib><title>One-year follow-up of transcoronary sinus administration of autologous bone marrow in patients with chronic refractory angina</title><title>Cardiovascular revascularization medicine</title><addtitle>Cardiovasc Revasc Med</addtitle><description>Based on our preclinic studies with autologous unfractionated bone marrow (AUBM) via coronary sinus with transitory occlusion, a clinic study in patients with chronic refractory angina was designed. The objectives were to evaluate tolerance of the procedure, safety, and feasibility with 1 year follow-up.
Clinical study with inclusion and exclusion criteria defined by an Independent Clinical Committee was carried out. Fifteen patients underwent transcoronary sinus administration with a 15-min occlusion of freshly aspirated and filtered AUBM (60–120 ml). Feasibility was evaluated with Seattle Angina Questionnaire (SAQ), Canadian Cardiovascular Society (CCS) angina classification, perfusion dipyridamole, and coronary angiography.
There were no changes in the tolerance parameters. There were no deaths or myocardial infarction during the follow-up. Three patients were readmitted into the hospital. During the follow-up, one patient was diagnosed with cancer of the lung. Improvement of 30% in the quality of life was evaluated by SAQ. The CCS angina classification showed that the mean angina class was 3.0±0.53 at baseline, which improved to 1.6±0.63 at 1 year (
P<.001).
Perfusion imaging (core lab) showed improvement in 12 of 15 patients, with a mean improvement of 40.9% at rest (22 vs. 13) (
P<.01) and 45.3% at stress (26.5 vs. 14.5) (
P<.05). Coronary angiography showed more collateral vessels in 10 of 15 patients.
We can conclude that AUBM via coronary sinus is feasible in patients with chronic refractory angina after 1 year follow-up, and it appears to be safe.</description><subject>Aged</subject><subject>Angina Pectoris - pathology</subject><subject>Angina Pectoris - physiopathology</subject><subject>Angina Pectoris - surgery</subject><subject>Angiogenesis</subject><subject>Autologous bone marrow</subject><subject>Bone Marrow Transplantation</subject><subject>Chronic refractory angina</subject><subject>Collateral circulation</subject><subject>Coronary Angiography</subject><subject>Coronary Circulation</subject><subject>Coronary sinus</subject><subject>Coronary Stenosis - pathology</subject><subject>Coronary Stenosis - physiopathology</subject><subject>Coronary Stenosis - surgery</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Reperfusion</subject><subject>No option patients</subject><subject>Patient Readmission</subject><subject>Pilot Projects</subject><subject>Prospective Studies</subject><subject>Quality of Life</subject><subject>Sickness Impact Profile</subject><subject>Time Factors</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><subject>Transplantation, Autologous</subject><subject>Treatment Outcome</subject><subject>Unfractionated bone marrow</subject><issn>1553-8389</issn><issn>1878-0938</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2LFDEQhoMo7rr6D0Ry8tZtpT-S9EWQZf2Ahb3oOVQnNbsZepIxSe8wB_-7GWbAm6cU1FNvqh7G3gtoBQj5adtaTIme2w5gbEG3AN0Ldi200g1MvX5Z63HsG93r6Yq9yXkL0KtOqtfsSshOjRLGa_bnIVBzJEx8E5clHpp1z-OGl4Qh25hiwHTk2Yc1c3Q7H3yureJjOFG4lrjEx1ibcwzEd3WheOA-8H1lKJTMD748cftUg7zliTYJbYk1EsOjD_iWvdrgkund5b1hv77e_bz93tw_fPtx--W-sQPI0kiCGbW0o5sGi0PnhOxnJWhGSROMk5vmbursCEqjQ6JB61mjEr3rJA1W9jfs4zl3n-LvlXIxO58tLQsGqtsbqZUahDqBwxm0KeZc9zX75OtZRyPAnLSbrTlrNyftBrSp2uvYh0v-Ou_I_Ru6eK7A5zNA9cpnT8lkWwVZcj6RLcZF__8f_gLlFJmE</recordid><startdate>20050701</startdate><enddate>20050701</enddate><creator>Vicario, Jose</creator><creator>Campo, Cesar</creator><creator>Piva, Julio</creator><creator>Faccio, Fernando</creator><creator>Gerardo, Luis</creator><creator>Becker, Carlos</creator><creator>Ortega, Hugo</creator><creator>Pierini, Angel</creator><creator>Lofeudo, Carlos</creator><creator>Novero, Rafael</creator><creator>Baliño, Nestor Perez</creator><creator>Monti, Adrian</creator><creator>Benech, Rodolfo</creator><creator>Dallo, Matias</creator><creator>Pfeiffer, Hernan</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050701</creationdate><title>One-year follow-up of transcoronary sinus administration of autologous bone marrow in patients with chronic refractory angina</title><author>Vicario, Jose ; 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The objectives were to evaluate tolerance of the procedure, safety, and feasibility with 1 year follow-up.
Clinical study with inclusion and exclusion criteria defined by an Independent Clinical Committee was carried out. Fifteen patients underwent transcoronary sinus administration with a 15-min occlusion of freshly aspirated and filtered AUBM (60–120 ml). Feasibility was evaluated with Seattle Angina Questionnaire (SAQ), Canadian Cardiovascular Society (CCS) angina classification, perfusion dipyridamole, and coronary angiography.
There were no changes in the tolerance parameters. There were no deaths or myocardial infarction during the follow-up. Three patients were readmitted into the hospital. During the follow-up, one patient was diagnosed with cancer of the lung. Improvement of 30% in the quality of life was evaluated by SAQ. The CCS angina classification showed that the mean angina class was 3.0±0.53 at baseline, which improved to 1.6±0.63 at 1 year (
P<.001).
Perfusion imaging (core lab) showed improvement in 12 of 15 patients, with a mean improvement of 40.9% at rest (22 vs. 13) (
P<.01) and 45.3% at stress (26.5 vs. 14.5) (
P<.05). Coronary angiography showed more collateral vessels in 10 of 15 patients.
We can conclude that AUBM via coronary sinus is feasible in patients with chronic refractory angina after 1 year follow-up, and it appears to be safe.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>16275605</pmid><doi>10.1016/j.carrev.2005.08.002</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Cardiovascular revascularization medicine, 2005-07, Vol.6 (3), p.99-107 |
| issn | 1553-8389 1878-0938 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Aged Angina Pectoris - pathology Angina Pectoris - physiopathology Angina Pectoris - surgery Angiogenesis Autologous bone marrow Bone Marrow Transplantation Chronic refractory angina Collateral circulation Coronary Angiography Coronary Circulation Coronary sinus Coronary Stenosis - pathology Coronary Stenosis - physiopathology Coronary Stenosis - surgery Feasibility Studies Female Follow-Up Studies Humans Male Middle Aged Myocardial Reperfusion No option patients Patient Readmission Pilot Projects Prospective Studies Quality of Life Sickness Impact Profile Time Factors Tomography, Emission-Computed, Single-Photon Transplantation, Autologous Treatment Outcome Unfractionated bone marrow |
| title | One-year follow-up of transcoronary sinus administration of autologous bone marrow in patients with chronic refractory angina |
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