Interaction of N1,N12-Diacetylspermine with Polyamine Transport Systems of Polarized Porcine Renal Cell Line LLC-PK1

LLC-PK1 cells grown on porous membrane filters were employed as a model system to explore the renal transport of polyamines. The polarity of LLC-PK1 monolayers was confirmed by the exclusive appearance of a Na+-dependent α-methylglucoside transport system on the apical surface. The uptake of free po...

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Veröffentlicht in:	Journal of biochemistry (Tokyo) 2005-10, Vol.138 (4), p.479-484
Hauptverfasser:	Miki, Toshiaki, Hiramatsu, Kyoko, Kawakita, Masao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport Biomarkers, Tumor - pharmacokinetics Cell Polarity diacetylspermine DiAcSpm LLC-PK1 Cells - cytology LLC-PK1 Cells - metabolism N12-diacetylspermine p-chloromercuriphenyl sulfate PBS PCMPS phosphate-buffered saline polyamine Polyamines - pharmacokinetics renal cell Spermine - analogs & derivatives Spermine - pharmacokinetics Swine transport tumor marker
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