Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma

The phosphatidylinositol 3-kinase pathway is an important regulator of a wide spectrum of tumor-related biological processes, including cell proliferation, survival, and motility, as well as neovascularization. Protein kinase B/Akt is activated in a complex manner through the phosphorylation of prot...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular cancer therapeutics 2005-11, Vol.4 (11), p.1681-1688
Hauptverfasser:	Koul, Dimpy, Shen, Ruijun, Bergh, Sherry, Lu, Yiling, de Groot, John F, Liu, Ta Jen, Mills, Gordon B, Yung, W K Alfred
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt Blotting, Western Cell Cycle Cell Division Cell Line, Tumor Cell Movement Cell Proliferation Cell Survival Disease Progression Dose-Response Relationship, Drug Down-Regulation Enzyme Activation Enzyme Inhibitors - pharmacology Enzyme-Linked Immunosorbent Assay Extracellular Matrix - metabolism Fibronectins - chemistry Fibronectins - metabolism G2 Phase Glioblastoma - enzymology Glioblastoma - pathology Glioma - therapy Humans ILK invasion and angiogenesis Matrix Metalloproteinase 2 - metabolism mTOR Neoplasm Invasiveness Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Protein Structure, Tertiary Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Serine - chemistry Signal Transduction Threonine - chemistry Vascular Endothelial Growth Factor A - metabolism Vitronectin - chemistry Vitronectin - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!