Cloning of the promoter from the gonadal aromatase gene of the European sea bass and identification of single nucleotide polymorphisms
Aromatase contributes to sex differentiation by catalysing the conversion of androgens into estrogens. We have cloned the promoter of the gonadal aromatase gene from the sea bass, Dicentrarchus labrax, a species whose farming is complicated by male-skewed sex ratios. The promoter shows a conserved b...
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| Veröffentlicht in: | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology Molecular & integrative physiology, 2006-09, Vol.145 (1), p.47-53 |
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| container_title | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology |
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| creator | Galay-Burgos, Malyka Gealy, Claire Navarro-Martín, Laia Piferrer, Francesc Zanuy, Silvia Sweeney, Glen E. |
| description | Aromatase contributes to sex differentiation by catalysing the conversion of androgens into estrogens. We have cloned the promoter of the gonadal aromatase gene from the sea bass,
Dicentrarchus labrax, a species whose farming is complicated by male-skewed sex ratios. The promoter shows a conserved binding site for SF-1 as well as two cAMP response elements (CREs) and putative binding sites for transcription factors belonging to the Sox and forkhead families. Analysis of promoter sequences from individual fish suggests the presence of three promoter alleles that arise due to three single nucleotide polymorphisms (SNPs) in linkage disequilibrium. |
| doi_str_mv | 10.1016/j.cbpa.2006.04.028 |
| format | Article |
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Dicentrarchus labrax, a species whose farming is complicated by male-skewed sex ratios. The promoter shows a conserved binding site for SF-1 as well as two cAMP response elements (CREs) and putative binding sites for transcription factors belonging to the Sox and forkhead families. Analysis of promoter sequences from individual fish suggests the presence of three promoter alleles that arise due to three single nucleotide polymorphisms (SNPs) in linkage disequilibrium.</description><identifier>ISSN: 1095-6433</identifier><identifier>EISSN: 1531-4332</identifier><identifier>DOI: 10.1016/j.cbpa.2006.04.028</identifier><identifier>PMID: 16782377</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Alleles ; Animals ; Aromatase ; Aromatase - genetics ; Base Sequence ; Bass - genetics ; Cloning, Molecular ; Dicentrarchus labrax ; Electrophoretic Mobility Shift Assay ; Female ; Gene expression ; Gonadal ; Gonads - enzymology ; Gonads - metabolism ; Homeodomain Proteins - genetics ; Homeodomain Proteins - metabolism ; Male ; Marine ; Molecular Sequence Data ; Mutation - genetics ; Oligonucleotides - genetics ; Oligonucleotides - metabolism ; Polymorphism, Single Nucleotide - genetics ; Promoter ; Promoter Regions, Genetic - genetics ; Protein Binding ; Receptors, Cytoplasmic and Nuclear - genetics ; Receptors, Cytoplasmic and Nuclear - metabolism ; Sea bass ; Sequence Alignment ; Sex differentiation ; SF-1 ; SNPs ; Steroidogenic Factor 1 ; Transcription Factors - genetics ; Transcription Factors - metabolism</subject><ispartof>Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2006-09, Vol.145 (1), p.47-53</ispartof><rights>2006 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-f10ed630fa5c768c3d884dfa3d63f7e35daef97babcc043426e15d9f1371f4893</citedby><cites>FETCH-LOGICAL-c385t-f10ed630fa5c768c3d884dfa3d63f7e35daef97babcc043426e15d9f1371f4893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cbpa.2006.04.028$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16782377$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Galay-Burgos, Malyka</creatorcontrib><creatorcontrib>Gealy, Claire</creatorcontrib><creatorcontrib>Navarro-Martín, Laia</creatorcontrib><creatorcontrib>Piferrer, Francesc</creatorcontrib><creatorcontrib>Zanuy, Silvia</creatorcontrib><creatorcontrib>Sweeney, Glen E.</creatorcontrib><title>Cloning of the promoter from the gonadal aromatase gene of the European sea bass and identification of single nucleotide polymorphisms</title><title>Comparative biochemistry and physiology. Part A, Molecular & integrative physiology</title><addtitle>Comp Biochem Physiol A Mol Integr Physiol</addtitle><description>Aromatase contributes to sex differentiation by catalysing the conversion of androgens into estrogens. We have cloned the promoter of the gonadal aromatase gene from the sea bass,
Dicentrarchus labrax, a species whose farming is complicated by male-skewed sex ratios. The promoter shows a conserved binding site for SF-1 as well as two cAMP response elements (CREs) and putative binding sites for transcription factors belonging to the Sox and forkhead families. Analysis of promoter sequences from individual fish suggests the presence of three promoter alleles that arise due to three single nucleotide polymorphisms (SNPs) in linkage disequilibrium.</description><subject>Alleles</subject><subject>Animals</subject><subject>Aromatase</subject><subject>Aromatase - genetics</subject><subject>Base Sequence</subject><subject>Bass - genetics</subject><subject>Cloning, Molecular</subject><subject>Dicentrarchus labrax</subject><subject>Electrophoretic Mobility Shift Assay</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gonadal</subject><subject>Gonads - enzymology</subject><subject>Gonads - metabolism</subject><subject>Homeodomain Proteins - genetics</subject><subject>Homeodomain Proteins - metabolism</subject><subject>Male</subject><subject>Marine</subject><subject>Molecular Sequence Data</subject><subject>Mutation - genetics</subject><subject>Oligonucleotides - genetics</subject><subject>Oligonucleotides - metabolism</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Promoter</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>Protein Binding</subject><subject>Receptors, Cytoplasmic and Nuclear - genetics</subject><subject>Receptors, Cytoplasmic and Nuclear - metabolism</subject><subject>Sea bass</subject><subject>Sequence Alignment</subject><subject>Sex differentiation</subject><subject>SF-1</subject><subject>SNPs</subject><subject>Steroidogenic Factor 1</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><issn>1095-6433</issn><issn>1531-4332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9uFSEUxomxsX_0BVwYVu5mhIGBmcSNuWlrkyZu6powcGi5mYERGJO-gM9drvcad8qGcz5-5yPwIfSekpYSKj7tWzOtuu0IES3hLemGV-iC9ow2nLHuda3J2DeiNufoMuc9qYtT_gadUyGHjkl5gX7t5hh8eMTR4fIEeE1xiQUSdrX4rTzGoK2esa6CLjpXBQL84a-3FFfQAWfQeNI5Yx0s9hZC8c4bXXwMBzbXO2bAYTMzxFLP8Rrn5yWm9cnnJb9FZ07PGd6d9iv0_eb6Yfe1uf92e7f7ct8YNvSlcZSAFYw43RspBsPsMHDrNKuik8B6q8GNctKTMYQz3gmgvR0dZZI6PozsCn08-tZ3_tggF7X4bGCedYC4ZSUGKakY-X9BOnYjG2VXwe4ImhRzTuDUmvyi07OiRB1iUnt1iEkdYlKEqxpTHfpwct-mBezfkVMuFfh8BKB-xk8PSWXjIRiwPoEpykb_L_8X9bGmiw</recordid><startdate>20060901</startdate><enddate>20060901</enddate><creator>Galay-Burgos, Malyka</creator><creator>Gealy, Claire</creator><creator>Navarro-Martín, Laia</creator><creator>Piferrer, Francesc</creator><creator>Zanuy, Silvia</creator><creator>Sweeney, Glen E.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7TN</scope><scope>8FD</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>H98</scope><scope>H99</scope><scope>L.F</scope><scope>L.G</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20060901</creationdate><title>Cloning of the promoter from the gonadal aromatase gene of the European sea bass and identification of single nucleotide polymorphisms</title><author>Galay-Burgos, Malyka ; Gealy, Claire ; Navarro-Martín, Laia ; Piferrer, Francesc ; Zanuy, Silvia ; Sweeney, Glen E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-f10ed630fa5c768c3d884dfa3d63f7e35daef97babcc043426e15d9f1371f4893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Alleles</topic><topic>Animals</topic><topic>Aromatase</topic><topic>Aromatase - genetics</topic><topic>Base Sequence</topic><topic>Bass - genetics</topic><topic>Cloning, Molecular</topic><topic>Dicentrarchus labrax</topic><topic>Electrophoretic Mobility Shift Assay</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gonadal</topic><topic>Gonads - enzymology</topic><topic>Gonads - metabolism</topic><topic>Homeodomain Proteins - genetics</topic><topic>Homeodomain Proteins - metabolism</topic><topic>Male</topic><topic>Marine</topic><topic>Molecular Sequence Data</topic><topic>Mutation - genetics</topic><topic>Oligonucleotides - genetics</topic><topic>Oligonucleotides - metabolism</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Promoter</topic><topic>Promoter Regions, Genetic - genetics</topic><topic>Protein Binding</topic><topic>Receptors, Cytoplasmic and Nuclear - genetics</topic><topic>Receptors, Cytoplasmic and Nuclear - metabolism</topic><topic>Sea bass</topic><topic>Sequence Alignment</topic><topic>Sex differentiation</topic><topic>SF-1</topic><topic>SNPs</topic><topic>Steroidogenic Factor 1</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Galay-Burgos, Malyka</creatorcontrib><creatorcontrib>Gealy, Claire</creatorcontrib><creatorcontrib>Navarro-Martín, Laia</creatorcontrib><creatorcontrib>Piferrer, Francesc</creatorcontrib><creatorcontrib>Zanuy, Silvia</creatorcontrib><creatorcontrib>Sweeney, Glen E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Technology Research Database</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Aquaculture Abstracts</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Comparative biochemistry and physiology. 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We have cloned the promoter of the gonadal aromatase gene from the sea bass,
Dicentrarchus labrax, a species whose farming is complicated by male-skewed sex ratios. The promoter shows a conserved binding site for SF-1 as well as two cAMP response elements (CREs) and putative binding sites for transcription factors belonging to the Sox and forkhead families. Analysis of promoter sequences from individual fish suggests the presence of three promoter alleles that arise due to three single nucleotide polymorphisms (SNPs) in linkage disequilibrium.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>16782377</pmid><doi>10.1016/j.cbpa.2006.04.028</doi><tpages>7</tpages></addata></record> |
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| subjects | Alleles Animals Aromatase Aromatase - genetics Base Sequence Bass - genetics Cloning, Molecular Dicentrarchus labrax Electrophoretic Mobility Shift Assay Female Gene expression Gonadal Gonads - enzymology Gonads - metabolism Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Male Marine Molecular Sequence Data Mutation - genetics Oligonucleotides - genetics Oligonucleotides - metabolism Polymorphism, Single Nucleotide - genetics Promoter Promoter Regions, Genetic - genetics Protein Binding Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Sea bass Sequence Alignment Sex differentiation SF-1 SNPs Steroidogenic Factor 1 Transcription Factors - genetics Transcription Factors - metabolism |
| title | Cloning of the promoter from the gonadal aromatase gene of the European sea bass and identification of single nucleotide polymorphisms |
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