Crystal Structure of a Complex between Protein Tyrosine Phosphatase 1B and the Insulin Receptor Tyrosine Kinase

Protein tyrosine phosphatase 1B (PTP1B) is a highly specific negative regulator of insulin receptor signaling in vivo. The determinants of PTP1B specificity for the insulin receptor versus other receptor tyrosine kinases are largely unknown. Here, we report a crystal structure at 2.3 Å resolution of...

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Veröffentlicht in:	Structure 2005-11, Vol.13 (11), p.1643-1651
Hauptverfasser:	Li, Shiqing, Depetris, Rafael S., Barford, David, Chernoff, Jonathan, Hubbard, Stevan R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cloning, Molecular CRYSTAL STRUCTURE Crystallization Crystallography, X-Ray Dimerization DIMERS Escherichia coli Humans IN VIVO INSULIN MATERIALS SCIENCE Mutation national synchrotron light source PHOSPHATASES Phosphorylation PHOSPHOTRANSFERASES Protein Binding Protein Tyrosine Phosphatase, Non-Receptor Type 1 - chemistry Protein Tyrosine Phosphatase, Non-Receptor Type 1 - genetics Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism Protein-Tyrosine Kinases - chemistry Protein-Tyrosine Kinases - metabolism PROTEINS RESOLUTION SPECIFICITY TRAPPING TYROSINE
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