Frequency of Aspirin Resistance in a Community Hospital
Aspirin resistance and its predictors were studied in community hospital patients who required antiplatelet therapy for thrombotic event prophylaxis. Demographic and antiplatelet medication data were collected and medication response followed. Aspirin resistance was assayed with the VerifyNow System...
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| Veröffentlicht in: | The American journal of cardiology 2006-09, Vol.98 (5), p.577-579 |
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| container_title | The American journal of cardiology |
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| creator | Mirkhel, Ahmadshah Peyster, Eliot Sundeen, James Greene, Linda Michelson, Alan D. Hasan, Ahmed Domanski, Michael |
| description | Aspirin resistance and its predictors were studied in community hospital patients who required antiplatelet therapy for thrombotic event prophylaxis. Demographic and antiplatelet medication data were collected and medication response followed. Aspirin resistance was assayed with the VerifyNow System with ≥550 aspirin reaction units (ARUs) used as a dichotomous indicator of aspirin resistance. Patients (n = 123) were 21 to 95 years old; 49.6% were women, 77.2% were black, 95.1% were hypertensive, 85.4% had coronary disease, and 30.1% were smokers. ARU score for 325 versus 81 mg/day was 435.2 ± 93.7 versus 401.9 ± 83.9 ARU (p = 0.04), with a 12.1% (8 of 66 patietns) nonresponse rate to 81 mg/day. Of the 8 patients who were unresponsive to 81 mg/day of aspirin, 7 responded to 325 mg/day. The 5.3% (3 of 57 patients) who were resistant to 325 mg/day received clopidogrel; 2 became responders. Multivariate analysis demonstrated significant associations of aspirin resistance with smoking (risk ratio 11.47, 95% confidence interval 6.69 to 18.63, p |
| doi_str_mv | 10.1016/j.amjcard.2006.03.029 |
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Demographic and antiplatelet medication data were collected and medication response followed. Aspirin resistance was assayed with the VerifyNow System with ≥550 aspirin reaction units (ARUs) used as a dichotomous indicator of aspirin resistance. Patients (n = 123) were 21 to 95 years old; 49.6% were women, 77.2% were black, 95.1% were hypertensive, 85.4% had coronary disease, and 30.1% were smokers. ARU score for 325 versus 81 mg/day was 435.2 ± 93.7 versus 401.9 ± 83.9 ARU (p = 0.04), with a 12.1% (8 of 66 patietns) nonresponse rate to 81 mg/day. Of the 8 patients who were unresponsive to 81 mg/day of aspirin, 7 responded to 325 mg/day. The 5.3% (3 of 57 patients) who were resistant to 325 mg/day received clopidogrel; 2 became responders. Multivariate analysis demonstrated significant associations of aspirin resistance with smoking (risk ratio 11.47, 95% confidence interval 6.69 to 18.63, p <0.0001), including a significant interaction between smoking and aspirin resistance. In conclusion, this study estimates aspirin resistance prevalence and shows a strong association of smoking with platelet hyperactivity in a diverse community hospital population. Nonresponders to 81 mg/day frequently responded to 325 mg/day or to the addition of clopidogrel.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2006.03.029</identifier><identifier>PMID: 16923439</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Aspirin ; Aspirin - pharmacology ; Biological and medical sciences ; Cardiology. Vascular system ; Drug Resistance ; Drug therapy ; Female ; Hospitals ; Hospitals, Community - statistics & numerical data ; Humans ; Incidence ; Male ; Maryland - epidemiology ; Medical sciences ; Medical treatment ; Middle Aged ; Platelet Aggregation Inhibitors - pharmacology ; Prognosis ; Retrospective Studies ; Thrombosis - drug therapy</subject><ispartof>The American journal of cardiology, 2006-09, Vol.98 (5), p.577-579</ispartof><rights>2006 Elsevier Inc.</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Elsevier Sequoia S.A. Sep 1, 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-bcd603d654a7b44bb123762751263f0bbb9fc2687ecdc73596b5de9fc3b4ffce3</citedby><cites>FETCH-LOGICAL-c511t-bcd603d654a7b44bb123762751263f0bbb9fc2687ecdc73596b5de9fc3b4ffce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.amjcard.2006.03.029$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18082319$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16923439$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mirkhel, Ahmadshah</creatorcontrib><creatorcontrib>Peyster, Eliot</creatorcontrib><creatorcontrib>Sundeen, James</creatorcontrib><creatorcontrib>Greene, Linda</creatorcontrib><creatorcontrib>Michelson, Alan D.</creatorcontrib><creatorcontrib>Hasan, Ahmed</creatorcontrib><creatorcontrib>Domanski, Michael</creatorcontrib><title>Frequency of Aspirin Resistance in a Community Hospital</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>Aspirin resistance and its predictors were studied in community hospital patients who required antiplatelet therapy for thrombotic event prophylaxis. Demographic and antiplatelet medication data were collected and medication response followed. Aspirin resistance was assayed with the VerifyNow System with ≥550 aspirin reaction units (ARUs) used as a dichotomous indicator of aspirin resistance. Patients (n = 123) were 21 to 95 years old; 49.6% were women, 77.2% were black, 95.1% were hypertensive, 85.4% had coronary disease, and 30.1% were smokers. ARU score for 325 versus 81 mg/day was 435.2 ± 93.7 versus 401.9 ± 83.9 ARU (p = 0.04), with a 12.1% (8 of 66 patietns) nonresponse rate to 81 mg/day. Of the 8 patients who were unresponsive to 81 mg/day of aspirin, 7 responded to 325 mg/day. The 5.3% (3 of 57 patients) who were resistant to 325 mg/day received clopidogrel; 2 became responders. Multivariate analysis demonstrated significant associations of aspirin resistance with smoking (risk ratio 11.47, 95% confidence interval 6.69 to 18.63, p <0.0001), including a significant interaction between smoking and aspirin resistance. In conclusion, this study estimates aspirin resistance prevalence and shows a strong association of smoking with platelet hyperactivity in a diverse community hospital population. Nonresponders to 81 mg/day frequently responded to 325 mg/day or to the addition of clopidogrel.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aspirin</subject><subject>Aspirin - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Drug Resistance</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Hospitals</subject><subject>Hospitals, Community - statistics & numerical data</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Maryland - epidemiology</subject><subject>Medical sciences</subject><subject>Medical treatment</subject><subject>Middle Aged</subject><subject>Platelet Aggregation Inhibitors - pharmacology</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Thrombosis - drug therapy</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAURYMoOn78BKUIumvNS9pkspJhcFQQBNF1SNIUUvoxJq0w_96UKQy4cRVe3rmPy0HoGnAGGNhDnam2NsqXGcGYZZhmmIgjtIAlFykIoMdogTEmqYBcnKHzEOo4AhTsFJ0BE4TmVCwQ33j7PdrO7JK-SlZh67zrkg8bXBhUZ2wSJ5Ws-7YdOzfskpc-IoNqLtFJpZpgr-b3An1tnj7XL-nb-_PrevWWmgJgSLUpGaYlK3LFdZ5rDYRyRngBhNEKa61FZQhbcmtKw2khmC5KG_-ozqvKWHqB7vd3t76PPcMgWxeMbRrV2X4MMkY55BRH8PYPWPej72I3SeKacVxMULGHjO9D8LaSW-9a5XcSsJy0ylrOWuWkVWIqo9aYu5mPj7q15SE1e4zA3QyoYFRT-ejOhQO3xEtCYeIe95yNzn6c9TIYF-3b0nlrBln27p8qv_I_lzA</recordid><startdate>20060901</startdate><enddate>20060901</enddate><creator>Mirkhel, Ahmadshah</creator><creator>Peyster, Eliot</creator><creator>Sundeen, James</creator><creator>Greene, Linda</creator><creator>Michelson, Alan D.</creator><creator>Hasan, Ahmed</creator><creator>Domanski, Michael</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20060901</creationdate><title>Frequency of Aspirin Resistance in a Community Hospital</title><author>Mirkhel, Ahmadshah ; Peyster, Eliot ; Sundeen, James ; Greene, Linda ; Michelson, Alan D. ; Hasan, Ahmed ; Domanski, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-bcd603d654a7b44bb123762751263f0bbb9fc2687ecdc73596b5de9fc3b4ffce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aspirin</topic><topic>Aspirin - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Drug Resistance</topic><topic>Drug therapy</topic><topic>Female</topic><topic>Hospitals</topic><topic>Hospitals, Community - statistics & numerical data</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Maryland - epidemiology</topic><topic>Medical sciences</topic><topic>Medical treatment</topic><topic>Middle Aged</topic><topic>Platelet Aggregation Inhibitors - pharmacology</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Thrombosis - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mirkhel, Ahmadshah</creatorcontrib><creatorcontrib>Peyster, Eliot</creatorcontrib><creatorcontrib>Sundeen, James</creatorcontrib><creatorcontrib>Greene, Linda</creatorcontrib><creatorcontrib>Michelson, Alan D.</creatorcontrib><creatorcontrib>Hasan, Ahmed</creatorcontrib><creatorcontrib>Domanski, Michael</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mirkhel, Ahmadshah</au><au>Peyster, Eliot</au><au>Sundeen, James</au><au>Greene, Linda</au><au>Michelson, Alan D.</au><au>Hasan, Ahmed</au><au>Domanski, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Frequency of Aspirin Resistance in a Community Hospital</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2006-09-01</date><risdate>2006</risdate><volume>98</volume><issue>5</issue><spage>577</spage><epage>579</epage><pages>577-579</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>Aspirin resistance and its predictors were studied in community hospital patients who required antiplatelet therapy for thrombotic event prophylaxis. Demographic and antiplatelet medication data were collected and medication response followed. Aspirin resistance was assayed with the VerifyNow System with ≥550 aspirin reaction units (ARUs) used as a dichotomous indicator of aspirin resistance. Patients (n = 123) were 21 to 95 years old; 49.6% were women, 77.2% were black, 95.1% were hypertensive, 85.4% had coronary disease, and 30.1% were smokers. ARU score for 325 versus 81 mg/day was 435.2 ± 93.7 versus 401.9 ± 83.9 ARU (p = 0.04), with a 12.1% (8 of 66 patietns) nonresponse rate to 81 mg/day. Of the 8 patients who were unresponsive to 81 mg/day of aspirin, 7 responded to 325 mg/day. The 5.3% (3 of 57 patients) who were resistant to 325 mg/day received clopidogrel; 2 became responders. Multivariate analysis demonstrated significant associations of aspirin resistance with smoking (risk ratio 11.47, 95% confidence interval 6.69 to 18.63, p <0.0001), including a significant interaction between smoking and aspirin resistance. In conclusion, this study estimates aspirin resistance prevalence and shows a strong association of smoking with platelet hyperactivity in a diverse community hospital population. Nonresponders to 81 mg/day frequently responded to 325 mg/day or to the addition of clopidogrel.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>16923439</pmid><doi>10.1016/j.amjcard.2006.03.029</doi><tpages>3</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Aspirin Aspirin - pharmacology Biological and medical sciences Cardiology. Vascular system Drug Resistance Drug therapy Female Hospitals Hospitals, Community - statistics & numerical data Humans Incidence Male Maryland - epidemiology Medical sciences Medical treatment Middle Aged Platelet Aggregation Inhibitors - pharmacology Prognosis Retrospective Studies Thrombosis - drug therapy |
| title | Frequency of Aspirin Resistance in a Community Hospital |
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