Direct Role for Dual Oxidase in Drosophila Gut Immunity

Because the mucosal epithelia are in constant contact with large numbers of microorganisms, these surfaces must be armed with efficient microbial control systems. Here, we show that the Drosophila nicotinamide adenine dinucleotide phosphate (NADPH) oxidase enzyme, dual oxidase (dDuox), is indispensa...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2005-11, Vol.310 (5749), p.847-850
Hauptverfasser:	Ha, Eun-Mi, Oh, Chun-Taek, Bae, Yun Soo, Lee, Won-Jae
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Attrition (Research Studies) Bacteria - growth & development Bacteria - immunology bacterial contamination bacterial infections Biochemistry. Physiology. Immunology Biological and medical sciences Catalase - genetics Catalase - metabolism Chlorides - metabolism Colony Count, Microbial Digestive System - enzymology Digestive System - immunology Digestive System - microbiology digestive tract disease resistance Drosophila Drosophila - enzymology Drosophila - immunology Drosophila - microbiology Drosophila melanogaster dual oxidase enzyme activity Enzymes Eukaryotes foods Fundamental and applied biological sciences. Psychology Immune system Immunity Immunity, Innate In Vitro Techniques Infections ingestion Innate immunity Insecta Insects Intestinal Mucosa - enzymology Intestinal Mucosa - immunology Intestinal Mucosa - microbiology Intestines Invertebrates Materials Microbiology Microorganisms Mortality Rate NADPH oxidase NADPH Oxidases - genetics NADPH Oxidases - metabolism Oxidases oxidoreductases Phagocytes Physiology. Development Reactive Oxygen Species - metabolism Respiratory Burst RNA Interference Saccharomyces cerevisiae - growth & development Saccharomyces cerevisiae - immunology Superoxides Superoxides - metabolism T lymphocytes
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