Inhibition of CCR5-mediated infection by diverse R5 and R5X4 HIV and SIV isolates using novel small molecule inhibitors of CCR5: Effects of viral diversity, target cell and receptor density

Highly active anti-retroviral therapy (HAART) has been very effective in reducing viral loads in human immunodeficiency virus (HIV)-1 patients. However, current therapies carry detrimental side effects, require complex drug regimes and are threatened by the emergence of drug-resistant variants. Ther...

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Veröffentlicht in:	Antiviral research 2005-11, Vol.68 (2), p.96-108
Hauptverfasser:	Willey, Samantha, Peters, Paul J., Sullivan, W. Matthew, Dorr, Patrick, Perros, Manos, Clapham, Paul R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences CCR5 CCR5 Receptor Antagonists CD4 Antigens - drug effects Cell Line Chemokine CCL5 - pharmacology Coreceptor inhibitor Down-Regulation - drug effects HAART HIV coreceptors HIV Infections - immunology HIV Infections - prevention & control HIV-1 - drug effects HIV-1 - immunology HIV-1 - physiology HIV-2 - drug effects HIV-2 - immunology HIV-2 - physiology Human immunodeficiency virus 1 Human immunodeficiency virus 2 Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Macrophages - drug effects Medical sciences Monocytes - drug effects Monocytes - virology Pharmacology. Drug treatments Quaternary Ammonium Compounds - pharmacology Receptors, CCR5 - immunology Receptors, CCR5 - metabolism Receptors, Cell Surface - metabolism Simian Acquired Immunodeficiency Syndrome - immunology Simian Acquired Immunodeficiency Syndrome - prevention & control Simian immunodeficiency virus Simian Immunodeficiency Virus - drug effects Simian Immunodeficiency Virus - immunology Simian Immunodeficiency Virus - physiology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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