Multinucleated foreign body giant cells in placental membrane

We report the pathologic finding of a multinucleated foreign body giant cell reaction to squames and fetal hair in the placental membranes in a 37-week 1-day intrauterine gestation. This reaction appeared to have developed in association with repeated intrauterine procedures performed in the third t...

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Veröffentlicht in:Pediatric and developmental pathology 2005-07, Vol.8 (4), p.493-496
Hauptverfasser: Sheridan, Todd, Askin, Frederic B, Ji, Hongxiu
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creator Sheridan, Todd
Askin, Frederic B
Ji, Hongxiu
description We report the pathologic finding of a multinucleated foreign body giant cell reaction to squames and fetal hair in the placental membranes in a 37-week 1-day intrauterine gestation. This reaction appeared to have developed in association with repeated intrauterine procedures performed in the third trimester, including cordocentesis for fetal blood sampling, intrauterine blood transfusion, and amnioreduction for polyhydramnios. This type of reaction most likely was directed to prolonged amniotic fluid leakage that occurred spontaneously or after intrauterine procedures in the second half of the second trimester and the third trimester. Careful examination of the placental membranes and recognition of the foreign body giant cell reaction may provide etiologic insight in cases of unexplained oligohydramnios.
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subjects Adult
Amniotic Fluid
Biomarkers - metabolism
Blood Transfusion, Intrauterine - adverse effects
Cordocentesis - adverse effects
Decidua - metabolism
Decidua - pathology
Drainage - adverse effects
Female
Fetal Membranes, Premature Rupture
Foreign-Body Reaction - etiology
Foreign-Body Reaction - metabolism
Foreign-Body Reaction - pathology
Giant Cells - metabolism
Giant Cells - pathology
Giant Cells, Foreign-Body - metabolism
Giant Cells, Foreign-Body - pathology
Humans
Immunoenzyme Techniques
Polyhydramnios - diagnosis
Polyhydramnios - therapy
Postoperative Complications
Pregnancy
Trophoblasts - metabolism
Trophoblasts - pathology
title Multinucleated foreign body giant cells in placental membrane
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