Ceruloplasmin is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis

Nitrite represents a bioactive reservoir of nitric oxide (NO) that may modulate vasodilation, respiration and cytoprotection after ischemia-reperfusion injury. Although nitrite formation is thought to occur via reaction of NO with oxygen, this third-order reaction cannot compete kinetically with the...

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Veröffentlicht in:	Nature chemical biology 2006-09, Vol.2 (9), p.486-493
Hauptverfasser:	Shiva, Sruti, Wang, Xunde, Ringwood, Lorna A, Xu, Xueying, Yuditskaya, Susan, Annavajjhala, Vidhya, Miyajima, Hiroaki, Hogg, Neil, Harris, Zena Leah, Gladwin, Mark T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemical Engineering Biochemistry Bioorganic Chemistry Blood Buffers Catalysis Cell Biology Ceruloplasmin - genetics Ceruloplasmin - metabolism Chemistry Chemistry and Materials Science Chemistry/Food Science Endocrine system Endocrine System - enzymology Endocrine System - metabolism Endocrine System - physiology Erythrocytes - drug effects Erythrocytes - metabolism Female Homeostasis - drug effects Homeostasis - genetics Homeostasis - physiology Humans Hydration Hypoxia In Vitro Techniques Liver - blood supply Male Mice Mice, Transgenic Nitric oxide Nitric Oxide - physiology Nitric Oxide Synthase - blood Nitric Oxide Synthase - metabolism Nitrites - blood Nitrites - therapeutic use Oxidation Oxidation-Reduction Physiology Plasma Plasma - enzymology Reperfusion Injury - blood Reperfusion Injury - drug therapy Reperfusion Injury - metabolism Respiration Vasodilation - drug effects Vasodilation - physiology
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